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Application of progesterones in preparing medicament for curing severe stroke and brain injury

A technology of cerebral apoplexy and progesterone, which is applied in the application field of progesterone in the preparation of drugs for treating severe cerebral apoplexy and brain injury, can solve the problems that the fatality rate of acute severe patients cannot be reduced, and achieve the prevention and treatment of neurological function loss and prevention of acute Cerebral tissue necrosis and the effect of promoting neurological function recovery

Inactive Publication Date: 2009-06-03
严伟琪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the face of frequent cerebrovascular diseases, traffic accidents and natural disasters caused by acute severe cerebral apoplexy and brain injury patients, traditional drugs cannot reduce the mortality of acute severe patients, and there is always a lack of a simple and effective Therapeutic drugs

Method used

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  • Application of progesterones in preparing medicament for curing severe stroke and brain injury
  • Application of progesterones in preparing medicament for curing severe stroke and brain injury
  • Application of progesterones in preparing medicament for curing severe stroke and brain injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Long-term toxicity test

[0031] Long-term toxicity test for dogs (intravenous injection: 15 mg / kg body weight, once every 12 hours, administration time for 20 weeks) and rat long-term toxicity test (subcutaneous administration: 240 mg / kg body weight, each It is administered once every 72 hours, and the administration time is 24 weeks).

[0032] The results showed that there were no abnormal changes in the tested animals, and there were no abnormalities in the blood biochemical index examination and the main organs, indicating that the application of the drug in large doses is safe and non-toxic, and the clinical medication will be relatively safe. The results of pharmacological studies on the mental nervous system of mice show that it has no obvious inhibitory effect on the behavioral performance and balance ability of mice. It has no obvious effect on the indicators of the cardiovascular and respiratory system of anesthetized dogs, such as blood pressure, heart...

Embodiment 2

[0033] Example 2: Protective effect of progesterone on nerve cells after ischemic brain injury in rats

[0034] 100 male SD rats were randomly divided into four groups: (1) sham operation group without thread plug; (2) ischemia-reperfusion group: after ligating the bilateral carotid arteries and then removing the arterial clamp, using thread plug method to block The middle cerebral artery (MCAO) was cut to make a rat model of focal ischemia-reperfusion brain injury without administration; (3) Ischemia-reperfusion group + normal saline injection group (normal saline group), same as (2) established Rat focal ischemia-reperfusion brain injury model, intraperitoneal injection of 1 mL of normal saline 6 hours after operation, twice a day for 5 days; (4) Ischemia-reperfusion group + progesterone injection 0.5 mg / kg intramuscular injection group (Progesterone group); Same as (2) to establish a rat model of focal ischemia-reperfusion brain injury, 6 hours after surgery, intramuscular inje...

Embodiment 3

[0042] Example 3: The therapeutic effect of progesterone skin embedding agent on cerebral edema in rats

[0043] Eighty male SD rats (4 to 5 weeks old, weighing about 150g) were randomly divided into normal group, trauma group, normal saline control group, and progesterone skin implant treatment group. ①Normal group, no treatment; ②Trauma group, free fall (1000g·cm) hit the left parietal lobe to make a brain injury model without administration; ③Saline group, make a brain injury model as in ②, abdominal cavity 6h after operation Inject 2mL of normal saline, once every 72h, for 7 days; ④The progesterone group was made into a brain injury model as in ②, and the implant was subcutaneously implanted 6h after the operation (1.5mg / head based on the mass of progesterone, administered every 72h Once) for 7 days. Observation indicators were measured 24h and 7d after trauma: (1) Magnetic resonance: T2 imaging of the rat brain was examined and the image signal values ​​of the two-fold magnif...

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Abstract

The invention provides an application of progesterones in preparing medicament for curing severe stroke and brain injury. The medicament can be prepared into intravenous injection, muscle injection or implant according to the conventional method in the field. Continuously feeding injection or implant of the medicament is needed within 8 hours after severe stroke and brain injury occur. The application mainly has the beneficial effects that a new application of progesterones in preparing medicament for curing severe stroke and brain injury is provided, acute cerebral necrosis caused by severe stroke and brain injury can be effectively prevented, nerve function recovery of patients with ischemic brain injury can be promoted, the death rate can be reduced, therefore, the application has good clinical application prospect.

Description

(1) Technical field [0001] The invention relates to the application of progesterone in the preparation of medicines for treating severe cerebral apoplexy and brain injury. To provide a drug approach that prevents acute brain tissue necrosis, promotes the recovery of neurological function in patients with brain injury, and reduces mortality. (2) Background technology [0002] In acute severe hemorrhagic and ischemic brain injury, stroke and traumatic brain injury are the most common. They are important diseases threatening human life and important causes of clinical death and disability. The results of the national cause of death survey published by the Ministry of Health show that cerebrovascular Disease has become the first cause of death in urban and rural residents in my country, accounting for 22.45% of the total deaths. According to the survey, about 2 million new strokes occur every year in the country, and about 1.5 million die from cerebrovascular diseases every year. In ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61P9/10
Inventor 严伟琪
Owner 严伟琪
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