Process for preparing degradable strontium-doped biphasic calcium phosphate bioactive bone cement

A biphasic calcium phosphate biological and preparation technology, which is applied in dental preparations, medical science, dentistry, etc., can solve the problems of unsuitable human bone repair, long degradation time, and no strength, so as to overcome the difficult formability and broad clinical application Foreground, Overcoming Intensity and Effect of Secondary Migration

Inactive Publication Date: 2009-06-03
XI AN JIAOTONG UNIV
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AI Technical Summary

Problems solved by technology

In 1995, American scholars reported on Science [Constantz BR, IsonIC, Fulmer MT, et al. Skeletal repair by in situ formation of the mineral phase of bone. Science, 1995; 257: 1796-1799.] Carbonate was used as Carbonated apatite bone cement can be obtained after one of the solid phase components is mixed with calcium phosphate bone cement, and its degradation performance has been significantly improved, but the degradation time is still relatively long compared with the faster bone tissue growth rate
In 2001, French scholars (L.Lerous, J.L.Lacout.Preparation of calcium strontium hydroxyapatites by a new route involving calcium phosphate cements.J.Mater.Res.2001, 16(1):171~178) made strontium nitrate Sr(NO 3 ) 2 Incorporation of H 3 PO 4 The aqueous solution is used as the solidification liquid, and the solid phase powder Ca 4 (PO 4 ) 2 O and α-Ca 3 (P

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1：0.6g(Ca4(PO4)2O and β-Sr0.15Ca2.85(PO4)21:(2+0.5)，m＝2，k＝0.5) and 0.26gy1mol/lH3PO4(x＝0.15；/z2.0:1) and 30s 1 ，6mm、12mm0.7MPa，6.5mm、13mm，37℃、100％，30min，SBF()，3d86.66％(Ca8.89Sr0.27(PO4)6(OH)0.32，(Ca+Sr)/P＝1.53，Sr/(Ca+Sr)＝2.95％) and 13.34％β-Sr0.15Ca2.85(PO4)2。SBF337.54MPa。3.5min，12.5min。 test 0。 Embodiment 2

[0016] Embodiment 1: 0.6g cement mixing powder (Ca 4 (PO 4 ) 2 O and β-Sr 0.15 Ca 2.85 (PO 4 ) 2 The molar ratio is 1:(2+0.5), i.e. m=2, k=0.5) and 0.26 g of H with a concentration y of 1 mol / l 3 PO 4 The aqueous solution (where x=0.15; solid / liquid mass ratio z is 2.0:1) was mixed with a spatula for 30s to form a uniform cement slurry, filled into a stainless steel cylinder mold with a diameter of 6mm and a height of 12mm and applied 0.7MPa The pressure is compacted, and the cylindrical sample is stuffed into a glass tube with a diameter of 6.5mm and a height of 13mm, and then placed in an environment with a temperature of 37°C and a relative humidity of 100% for curing. After pre-curing for 30 minutes, the The sample was taken out and immersed in SBF (simulated body fluid) rapidly. After 3 days, the final product composition of the solidified body was 86.66% strontium-doped hydroxyapatite (Ca 8.89 Sr 0.27 (PO 4 ) 6 (OH) 0.32 , (Ca+Sr) / P=1.53, strontium-doped amou...

Embodiment 3

[0017] Embodiment 3: 0.6g cement mixing powder (Ca 4 (PO 4 ) 2 O and β-Sr 2.5 Ca 0.5 (PO 4 ) 2 The molar ratio is 1:(2+0.5), i.e. m=2, k=0.5) and 0.255g concentration y is 1mol / l H 3 PO 4 The aqueous solution (where x=2.5; solid / liquid mass ratio z is 2.0:1) was mixed with a spatula for 30s to form a uniform cement slurry, filled into a stainless steel cylinder mold with a diameter of 6mm and a height of 12mm and applied 0.7MPa The pressure is compacted, and the cylindrical sample is stuffed into a glass tube with a diameter of 6.5mm and a height of 13mm, and then placed in an environment with a temperature of 37°C and a relative humidity of 100% for curing. After pre-curing for 30 minutes, the The sample was taken out and quickly immersed in SBF (simulated body fluid), and the final product composition of the solidified body after 3 days was 84.34% strontium-doped hydroxyapatite (Ca 4.53 Sr 4.54 (PO 4 ) 6 (OH) 0.14 , (Ca+Sr) / P=1.51, strontium-doped amount Sr / (Ca+S...

Embodiment 4

[0018] Embodiment 4: 0.6g cement mixing powder (Ca 4 (PO 4 ) 2 O and β-Sr 2.5 Ca 0.5 (PO 4 ) 2 The molar ratio is 1:(2+1), i.e. m=2, k=1) and 0.296g concentration y is 0.5mol / l H 3 PO 4 The aqueous solution (where x=2.5; solid / liquid mass ratio z is 1.5:1) was mixed with a spatula for 30s to form a uniform cement slurry, filled into a stainless steel cylinder mold with a diameter of 6mm and a height of 12mm and applied 0.7MPa The pressure is compacted, and the cylindrical sample is stuffed into a glass tube with a diameter of 6.5mm and a height of 13mm, and then placed in an environment with a temperature of 37°C and a relative humidity of 100% for curing. After pre-curing for 30 minutes, the The sample was taken out and immersed in SBF (simulated body fluid) quickly, and the final product composition of the solidified body after 3 days was 71.11% strontium-doped hydroxyapatite (Ca 4.68 Sr 4.68 (PO 4 ) 6 (OH) 0.72 , (Ca+Sr) / P=1.56, strontium-doped amount Sr / (Ca+Sr)...

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Abstract

The invention discloses a process for preparing degradable strontium-doped biphasic calcium phosphate bioactive bone cement. The cement solid phase adopted by the process is a mixed powder containing Ca4(PO4)2O and Beta-SrxCa3-x(PO4) which are distributed in a certain grain fineness and prepared by a certain molar ratio; the aqueous phase is a water deionized dilute phosphoric acid solution or a dilute phosphoric acid solution with the concentration being lower than 2.0 mol/l; the mass ratio of the reacted solid phase to the reacted aqueous phase is 0.1 to 4.0; and the final products under the physiological environment are strontium-doped hydroxylapatite and residual Beta-SrxCa3-x(PO4). The bone cement has the advantages that the mechanical property is higher; the setting time is proper; the phase composition of the product is changeable; strontium doping content and the calcium strontium/phosphorus ratio are adjustable; the degradation rate is controllable; and the like. Compared with the conventional calcium phosphate bone cement and calcium phosphate bone cement of other types, the biological active bone cement has wider clinical application prospect.

Description

technical field [0001] The invention relates to a preparation process of bioactive bone cement, in particular to a preparation process of degradable strontium-doped biphasic calcium phosphate bioactive bone cement. Background technique [0002] Calcium Phosphate Cement (CPC) has a porous structure and the cured product is hydroxyapatite, which has good biocompatibility and osteoconductivity, and can be processed into a slurry form and directly injected into bone defects. In situ solidification, thus widely used in dental bone replacement, orthodontic and reconstructive surgery. Calcium phosphate bone cement is mainly composed of two parts: calcium phosphate powder and curing liquid. The solidification solution is generally water or dilute phosphoric acid aqueous solution, and the calcium phosphate powder mainly includes tetracalcium phosphate (Ca 4 (PO 4 ) 2 O), calcium hydrogen phosphate (CaHPO 4 2H 2 O or CaHPO 4 ), calcium dihydrogen phosphate (Ca(H 2 PO 4 ) 2 ·...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/04A61L27/50A61K6/033A61K6/04A61K6/838
Inventor 郭大刚祁文莉徐可为憨勇
Owner XI AN JIAOTONG UNIV
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