Process for preparing degradable strontium-doped biphasic calcium phosphate bioactive bone cement

Abstract

The invention discloses a process for preparing degradable strontium-doped biphasic calcium phosphate bioactive bone cement. The cement solid phase adopted by the process is a mixed powder containing Ca4(PO4)2O and Beta-SrxCa3-x(PO4) which are distributed in a certain grain fineness and prepared by a certain molar ratio; the aqueous phase is a water deionized dilute phosphoric acid solution or a dilute phosphoric acid solution with the concentration being lower than 2.0 mol / l; the mass ratio of the reacted solid phase to the reacted aqueous phase is 0.1 to 4.0; and the final products under the physiological environment are strontium-doped hydroxylapatite and residual Beta-SrxCa3-x(PO4). The bone cement has the advantages that the mechanical property is higher; the setting time is proper; the phase composition of the product is changeable; strontium doping content and the calcium strontium / phosphorus ratio are adjustable; the degradation rate is controllable; and the like. Compared with the conventional calcium phosphate bone cement and calcium phosphate bone cement of other types, the biological active bone cement has wider clinical application prospect.

Description

technical field [0001] The invention relates to a preparation process of bioactive bone cement, in particular to a preparation process of degradable strontium-doped biphasic calcium phosphate bioactive bone cement. Background technique [0002] Calcium Phosphate Cement (CPC) has a porous structure and the cured product is hydroxyapatite, which has good biocompatibility and osteoconductivity, and can be processed into a slurry form and directly injected into bone defects. In situ solidification, thus widely used in dental bone replacement, orthodontic and reconstructive surgery. Calcium phosphate bone cement is mainly composed of two parts: calcium phosphate powder and curing liquid. The solidification solution is generally water or dilute phosphoric acid aqueous solution, and the calcium phosphate powder mainly includes tetracalcium phosphate (Ca 4 (PO 4 ) 2 O), calcium hydrogen phosphate (CaHPO 4 2H 2 O or CaHPO 4 ), calcium dihydrogen phosphate (Ca(H 2 PO 4 ) 2 ·...

AI Technical Summary

Problems solved by technology

In 1995, American scholars reported on Science [Constantz BR, IsonIC, Fulmer MT, et al. Skeletal repair by in situ formation of the mineral phase of bone. Science, 1995; 257: 1796-1799.] Carbonate was used as Carbonated apatite bone cement can be obtained after one of the solid phase components is mixed with calcium phosphate bone cement, and its degradation performance has been significantly improved, but the degradation time is still relatively long compared with the faster bone tissue growth rate

In 2001, French scholars (L.Lerous, J.L.Lacout.Preparation of calcium strontium hydroxyapatites by a new route involving calcium phosphate cements.J.Mater.Res.2001,16(1):171~178) made strontium nitrate Sr(NO 3 ) 2 Incorporation of H 3 PO 4 The aqueous solution is used as the solidification liquid, and the solid phase powder Ca 4 (PO 4 ) 2 O and α-Ca 3 (PO 4 ) 2 The strontium-doped apatite bone cement is obtained by mixing, but the disadvantage is that the final cured product contains a large amount of NO which is harmful to human tissue 3 - ions, not suitable for clinical applications such as human bone repair, follow-up research on mechanical properties and similar content have not been reported

However, when strontium-doped biphasic calcium phosphate ceramics repair bone defects in the form of a block, there is inevitably the disadvantage of difficult formability (that is, it is difficult to process into complex shapes suitable for repairing bone defects with special anatomical shapes), while Although the shortcoming of difficulty in forming is solved when the bone defect is directly repaired with powder, it has no strength when used in vivo and is prone to secondary migration with the flow of body fluids.