The use of bacillus PB6 for the prophylaxis or treatment of gastrointestinal and immuno-related diseases

An intestinal disease, Bacillus technology, applied in the direction of using bacteria, medical raw materials derived from bacteria, medical preparations that are not active ingredients, etc.
CN101448398AInactive Publication Date: 2009-06-03KEMIN IND INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KEMIN IND INC
Publication Date
2009-06-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

Bacteria of the sp. Bacillus that produce a lipopeptide are found to be effective in the treatment and prophylaxis of gastro-intestinal disease when administered as a probiotic. In particular, a strain of Bacillus bacteria identified as PB6 is useful for the treatment of Antibiotic Associated Diarrhea (AAD) or the more serious condition Clostridium difficile associated diarrhea (CDAD) when administered as a probiotic. Additionally, these bacteria have been found efficient for the treatment of immunorelated diseases such as Inflammatory Bowel Disease (IBD).
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Description

[0001] This application claims priority to US Patent Application Serial No. 60 / 740,518 filed November 29,2005. Background of the invention

[0002] The present invention relates generally to the administration of bacteria to treat gastrointestinal disorders, and more particularly to the administration of Bacillus amyloliquefaciens strains to treat antibiotic-associated diarrhea (AAD) and Clostridium difficile-associated disease (CDAD).

[0003] The term "antibiotic-associated diarrhea" refers to benign, self-limited diarrhea following the administration of antimicrobial agents. Typically, no causative agent has been identified for such diarrhea, which results from altered composition and function of the gut microbiota. Most patients responded to supportive measures and discontinuation of antibiotics.

[0004] Long-term use of multiple antibiotics, especially broad-spectrum antibiotics with poor intestinal absorption or high bile secretion, leads to changes in the composition ...

Claims

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