Purification method of Panax notoginseng saponins

A technology of Panax notoginseng saponins and a purification method, which is applied in the field of purifying Panax notoginseng saponins, can solve the problems that cannot be completely removed, affect the stability and safety of preparations, stability, and safety issues, and achieve easy operation and improved purity , The effect of simple production process

Active Publication Date: 2009-06-10
云南三七科技药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are both active ingredients and invalid impurities. It is because the impurities such as inorganic salts, tannins, proteins and macromolecules are not effectively removed that the stability and safety of the preparation are affected.
At present, the production process of extrac

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Raw materials: Panax notoginseng

[0024] Membrane material: The ultrafiltration membrane material is polypropylene with a molecular weight cut-off of 10,000, and the structure is a hollow fiber ultrafiltration membrane; the nanofiltration membrane material is an aramid composite membrane with a molecular weight cut-off of 500.

[0025] Panax notoginseng→crushing→ethanol extraction→upper macroporous resin column→alumina peroxide column→add appropriate amount of activated carbon for needles, titanium rod filtration→ultrafiltration→nanofiltration→refining and concentration→drying→crushing→refined product of Panax notoginseng saponins. Among them, the process of notoginseng→crushing→ethanol leaching→upper macroporous resin column→alumina peroxide column→adding appropriate amount of activated carbon for needles, filtering with titanium rod, and refining and concentrating→drying→crushing→the refined product of Panax notoginseng saponins All carried out according to the exist...

Embodiment 2

[0030] Raw materials: Panax notoginseng

[0031] Membrane material: The ultrafiltration membrane material is polysulfone membrane, with a molecular weight cut-off of 100,000, and the structure is a hollow fiber ultrafiltration membrane; the nanofiltration membrane material is polyacrylonitrile, with a molecular weight cut-off of 500.

[0032] Panax notoginseng→crushing→ethanol extraction→upper macroporous resin column→alumina peroxide column→add appropriate amount of activated carbon for needles, titanium rod filtration→ultrafiltration→nanofiltration→refining and concentration→drying→crushing→refined product of Panax notoginseng saponins.

[0033] The ultrafiltration adopts cross-flow filtration, the inlet pressure of the ultrafiltrate is 0.15MPa, the outlet pressure is lower than the inlet pressure, and the feed-liquid flow rate is 27.91mL / s. The temperature of the feed liquid is 25°C; the pH value of the feed liquid is 7.24; when the raw liquid of the feed liquid is ultra-fi...

Embodiment 3

[0037] Raw materials: Panax notoginseng

[0038] Membrane material: The ultrafiltration membrane material is polysulfone membrane with a molecular weight cut-off of 100,000, and the structural form is a coiled membrane; the nanofiltration membrane material is an aromatic polyamide composite membrane with a molecular weight cut-off of 200.

[0039] Panax notoginseng→crushing→ethanol extraction→upper macroporous resin column→alumina peroxide column→add appropriate amount of activated carbon for needles, titanium rod filtration→ultrafiltration→nanofiltration→refining and concentration→drying→crushing→refined product of Panax notoginseng saponins.

[0040] The ultrafiltration adopts cross-flow filtration, the inlet pressure of the ultrafiltrate is 0.2MPa, the pressure of the liquid outlet is lower than that of the liquid inlet, the flow rate of the feed liquid is 50mL / s, and the filtration rate of the ultrafiltration material is 93.31%; the temperature of the feed liquid is 22 ℃; ...

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Abstract

The invention relates to a notoginsen triterpenes purifying method using ultra-filtration and nano-filtration technology to extract trashes and purify the notoginsen triterpenes in notoginsen triterpenes production process using notoginseng as raw material. That is: notoginseng-> smashing-> enthanol eluting-> passing macroporous resin column-> passing alumina column->adding an amount of needle used active carbon, titanium rod filtering-> ultra-filtering-> nano-filtering-> refining and concentrating->drying->smashing-> notoginsen triterpenes. The process can also be used in Xuesaitong injection production process using notoginsen triterpenes as raw material. That is: adding water for injection into notoginsen triterpenes, mixing and boiling-> adding active carbon, filtering and fine-filtering->ultra-filtering->nano-filtering->adding an amount of sodium chloride, regulating pH value, diluting by an amount of water and obtaining the Xuesaitong injection. The invention achieves the advantages of simple production process, simple operation, good separation effect and no damage to bioactive substances, can eliminate macromolecular substance impurity and micromolecule substance impurity such as inorganic salt, thereby improving the purity of notoginsen triterpenes.

Description

technical field [0001] The invention relates to a method for purifying Panax notoginseng total saponins by ultrafiltration and nanofiltration technology. Background technique [0002] Membrane separation is a new separation technology that appeared in the early 20th century and rose rapidly after the 1960s. Membrane separation technology has been widely used in food, medicine, biology, Environmental protection, chemical industry, metallurgy, energy, petroleum, water treatment, electronics, bionics and other fields have produced huge economic and social benefits, and have become one of the most important means in today's separation science. [0003] Ultrafiltration is a kind of membrane separation technology. Its main part is ultrafiltration membrane, which is used for the separation of macromolecules in the solution. The ultrafiltration process is driven by the pressure difference on both sides of the membrane and based on the principle of mechanical sieving. This kind of ...

Claims

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Application Information

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IPC IPC(8): A61K36/258
Inventor 张国华赵洪陈彤甘献文张要武
Owner 云南三七科技药业有限公司
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