Purification method of Panax notoginseng saponins

Abstract

The invention relates to a notoginsen triterpenes purifying method using ultra-filtration and nano-filtration technology to extract trashes and purify the notoginsen triterpenes in notoginsen triterpenes production process using notoginseng as raw material. That is: notoginseng-> smashing-> enthanol eluting-> passing macroporous resin column-> passing alumina column->adding an amount of needle used active carbon, titanium rod filtering-> ultra-filtering-> nano-filtering-> refining and concentrating->drying->smashing-> notoginsen triterpenes. The process can also be used in Xuesaitong injection production process using notoginsen triterpenes as raw material. That is: adding water for injection into notoginsen triterpenes, mixing and boiling-> adding active carbon, filtering and fine-filtering->ultra-filtering->nano-filtering->adding an amount of sodium chloride, regulating pH value, diluting by an amount of water and obtaining the Xuesaitong injection. The invention achieves the advantages of simple production process, simple operation, good separation effect and no damage to bioactive substances, can eliminate macromolecular substance impurity and micromolecule substance impurity such as inorganic salt, thereby improving the purity of notoginsen triterpenes.

Description

technical field [0001] The invention relates to a method for purifying Panax notoginseng total saponins by ultrafiltration and nanofiltration technology. Background technique [0002] Membrane separation is a new separation technology that appeared in the early 20th century and rose rapidly after the 1960s. Membrane separation technology has been widely used in food, medicine, biology, Environmental protection, chemical industry, metallurgy, energy, petroleum, water treatment, electronics, bionics and other fields have produced huge economic and social benefits, and have become one of the most important means in today's separation science. [0003] Ultrafiltration is a kind of membrane separation technology. Its main part is ultrafiltration membrane, which is used for the separation of macromolecules in the solution. The ultrafiltration process is driven by the pressure difference on both sides of the membrane and based on the principle of mechanical sieving. This kind of ...

AI Technical Summary

Problems solved by technology

There are both active ingredients and invalid impurities. It is because the impurities such as inorganic salts, tannins, proteins and macromolecules are not effectively removed that the stability and safety of the preparation are affected.

At present, the production process of extracting total saponins of Panax notoginseng by using Panax notoginseng as raw material cannot completely remove the impurities of small molecules such as inorganic salts and some impurities of macromolecules, so that Xuesaitong and Xueshuantong injections are stable and safe. question