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Ceftibuten dispersible tablet

A technology of cefbutene and dispersible tablets, which is applied in the new field of medicine, can solve problems such as inconvenience, and achieve the effects of high quality, simple method and good stability

Inactive Publication Date: 2009-07-01
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the third-generation varieties need to be administered by injection, which is very inconvenient

Method used

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  • Ceftibuten dispersible tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: specification 1000 pieces

[0031] prescription:

[0032] Ceftibuten 200g

[0033] Microcrystalline Cellulose 280g

[0034] Starch 100g

[0035] Sodium carboxymethyl starch 120g

[0036] Aspartame 3g

[0037] Strawberry essence 2g

[0038] Micronized silica gel 8g

[0039] Magnesium Stearate 3g

[0040] Preparation method:

[0041] Take by weighing ceftibuten, microcrystalline cellulose, starch, half amount of sodium carboxymethyl starch, cross 80 mesh sieves and mix uniformly, granulate with 18 mesh sieves of 50% ethanol, add the other half amount of sodium carboxymethyl starch, Micronized silica gel, aspartame, strawberry essence, magnesium stearate, passed through a 20-mesh sieve for granulation, mixing, intermediate inspection, tableting.

Embodiment 2

[0042] Embodiment 2: specification 10000 pieces

[0043] prescription:

[0044] Ceftibuten 2000g

[0045] Microcrystalline Cellulose 2800g

[0046] Starch 1000g

[0047] Sodium Carboxymethyl Starch 1200g

[0048] Aspartame 30g

[0049] Strawberry essence 20g

[0050] Micronized silica gel 80g

[0051] Magnesium Stearate 30g

[0052] Preparation method:

[0053]Take by weighing ceftibuten, microcrystalline cellulose, starch, half amount of sodium carboxymethyl starch, cross 80 mesh sieves and mix uniformly, granulate with 18 mesh sieves of 50% ethanol, add the other half amount of sodium carboxymethyl starch, Micronized silica gel, aspartame, strawberry essence, magnesium stearate, passed through a 20-mesh sieve for granulation, mixing, intermediate inspection, tableting.

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PUM

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Abstract

The invention belongs to the novel technology field of the medicines and relates to a novel dosage form of ceftibuten for treating: upper respiratory tract infection such as pharyngitis, antiaditis, scarlet fever, paranasal sinusitis, and otitis medium; lower respiratory tract infection such as acute bronchitis, acute attack of chronic bronchitis and pneumonia; urinary tract infection; enteritis and gastroenteritis. The dosage form is characterized in that the dosage form is dispersing tablets, and can disintegrate quickly into fine granules when encountering water, and the granules uniformly disperse and can pass through size 2 sieve (24 mesh). Preparing the medicines with small dose and low water-solubility into the dispersing tablets can obviously improve absorption in vivo and improve bioavailability.

Description

technical field [0001] The invention belongs to the field of new medicine technology, and relates to a new dosage form of ceftibuten, which is used for treating upper respiratory tract infections such as pharyngitis, tonsillitis, scarlet fever, paranasal sinusitis and otitis media; lower respiratory tract infections such as acute bronchitis and acute chronic bronchitis seizures, pneumonia; urinary tract infection; enteritis and gastroenteritis. Specifically, it is a preparation method and application of ceftibuten dispersible tablets. Background technique [0002] Cephalosporin antibiotics have the characteristics of broad antibacterial spectrum, strong antibacterial activity, high curative effect, and low toxicity, and have been widely used clinically. By 1998, 56 varieties including the first generation to the fourth generation were on the market in the world. Since the first-generation cephalosporin cephalothin was successfully developed in China in the 1970s, cephalospo...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K9/20A61K47/38A61P1/00A61P11/00A61P11/02A61P11/04A61P13/00
Inventor 王翰斌闫艳立吴广俣
Owner BEIJING HOPE HUGE PHARM SCI
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