Cetirizine and pseudoephedrine sustained-release capsule and preparation method thereof
A technology of sustained-release capsules and cetirizine hydrochloride, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, and medical preparations containing active ingredients, etc. Inhomogeneity, complex processing and other problems, to achieve the effect of improving pharmacokinetic characteristics, good reproducibility of drug release, and uniform drug release
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Embodiment 1
[0045] ①Preparation of pseudoephedrine hydrochloride pills with the following weight ratio per 1000 capsules:
[0046] Pseudoephedrine Hydrochloride 120g
[0047] Dextrin 25g
[0048] Blank Ball Heart 30g
[0049] water 50g
[0050] Fully mix pseudoephedrine hydrochloride and dextrin evenly, then put the blank ball core into the multifunctional fluidized bed, and under the state of keeping the multifunctional fluidized bed rotating, gradually add the uniformly mixed materials under the wetting of water Into the multifunctional fluidized bed, wrapped on the blank core, and prepared into drug-containing pellets of pseudoephedrine hydrochloride.
[0051] Contain the following weight proportion system pseudoephedrine hydrochloride pellet coating by every 1000:
[0052] Pseudoephedrine Hydrochloride Pills 175g
[0053] Surelease (solid content 25%) 35g
[0054] water 23g
[0055] The drug-containing pellets were dried in an oven at 60°C. After drying, they were placed in a m...
Embodiment 2
[0070] ①Preparation of pseudoephedrine hydrochloride pills with the following weight ratio per 1000 capsules:
[0071] Pseudoephedrine Hydrochloride 120g
[0072] Dextrin 25g
[0073] Blank Ball Heart 30g
[0074] water 50g
[0075] Fully mix pseudoephedrine hydrochloride and dextrin evenly, then put the blank ball core into the multifunctional fluidized bed, and under the state of keeping the multifunctional fluidized bed rotating, gradually add the uniformly mixed materials under the wetting of water Into the multifunctional fluidized bed, wrapped on the blank core, and prepared into drug-containing pellets of pseudoephedrine hydrochloride.
[0076] Contain the following weight proportion system pseudoephedrine hydrochloride pellet coating by every 1000:
[0077] Pseudoephedrine Hydrochloride Pills 175g
[0078] Suris (25% solid content) 70g
[0079] water 46g
[0080] The drug-containing pellets were dried in an oven at 60°C. After drying, they were placed in a multi...
Embodiment 3
[0095] ①Preparation of pseudoephedrine hydrochloride pills with the following weight ratio per 1000 capsules:
[0096] Pseudoephedrine Hydrochloride 120g
[0097] Dextrin 25g
[0098] Blank Ball Heart 30g
[0099] water 50g
[0100] Fully mix pseudoephedrine hydrochloride and dextrin evenly, then put the blank ball core into the multifunctional fluidized bed, and under the state of keeping the multifunctional fluidized bed rotating, gradually add the uniformly mixed materials under the wetting of water Into the multifunctional fluidized bed, wrapped on the blank core, and prepared into drug-containing pellets of pseudoephedrine hydrochloride.
[0101] Contain the following weight proportion system pseudoephedrine hydrochloride pellet coating by every 1000:
[0102] Pseudoephedrine Hydrochloride Pills 175g
[0103] Suris (25% solid content) 140g
[0104] water 93g
[0105] The drug-containing pellets were dried in an oven at 60°C. After drying, they were placed in a mult...
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