Liquid external preparation for preparing total alkaloids in nux vomica

A technology of total alkaloids and external preparations, which is applied in the direction of anti-inflammatory agents, drug combinations, drug delivery, etc., can solve the problems that are not conducive to maintaining the clinical efficacy of Nuxebra chinensis medicinal materials, the enhancement of toxic and side effects, and the impact on the quality of preparations, so as to prolong the life of drugs. Action time, high compliance, and the effect of avoiding easy-to-stain clothes

Inactive Publication Date: 2009-08-05
XIANGTAN UNIV
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Guo Liwei and others reported that the total alkaloids of Nuxebra chinensis were made into a film-coating agent, but the stability of the preparation was only studied for two weeks, and slight stratification had occurred within two weeks, and many operational factors would affect the preparation process. The quality of the preparation is not suitable for industrialized large-scale production
In addition, many documents have reported the in vitro absorption, analgesic and anti-inflammatory studies of strychnine and strychnine liposomes. Numerous alkaloids contained in Semen strychnine have strong pharmacological effects. Strychnine is not conducive to maintaining the original clinical efficacy of strychnine, and its toxic and side effects may increase with the increase of strychnine concentration

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Liquid external preparation for preparing total alkaloids in nux vomica
  • Liquid external preparation for preparing total alkaloids in nux vomica
  • Liquid external preparation for preparing total alkaloids in nux vomica

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Total Alkaloids of Nuxychon 0.2g

[0075] Azone 5ml

[0076] Propylene glycol 30ml

[0077] Ethylparaben 0.1g

[0078] Add water to 100ml

[0079] In the prescription, the total alkaloids of St. Chinensis are the main drug, azone is a permeation enhancer, propylene glycol has the functions of a permeation enhancer, moisturizing and solvent, ethylparaben is a preservative, and water is a solvent.

[0080] Accurately weigh the total alkaloids of Nuxebra chinensis and dissolve in propylene glycol, add azone and ethylparaben; add appropriate amount of water to 100ml. It can be used as a liniment or paint by putting it into a packaging bottle; it can be used as a spray by putting it into an aerosol bottle with a special spray device; absorb the medicinal liquid with a special dressing, seal it and use it as a wet compress.

Embodiment 2

[0082] Nuxychnium Total Alkaloids 0.1g

[0083] Azone 5ml

[0084] Propylene glycol 10ml

[0085] Glycerin 35ml

[0086] Add water to 100ml

[0087] In the prescription, the total alkaloids of St. Chinensis are the main drug, azone and propylene glycol are the penetration enhancers, glycerin has moisturizing and antiseptic effects, and water is the solvent.

[0088] Accurately weigh the total alkaloids of Nuxebra chinensis and dissolve in propylene glycol, add azone and glycerin; add appropriate amount of water to 100ml. It can be used as a liniment or paint by putting it into a packaging bottle; it can be used as a spray by putting it into an aerosol bottle with a special spray device; absorb the medicinal liquid with a special dressing, seal it and use it as a wet compress.

Embodiment 3

[0090] Nuxychnium Total Alkaloids 0.4g

[0091] Oleic acid 10ml

[0092] Propylene glycol 10ml

[0093] Ethanol 25ml

[0094] Glycerin 25ml

[0095] Add water to 100ml

[0096] In the prescription, the total alkaloids of St. Chinensis are the main agent, oleic acid and propylene glycol are the penetration enhancers, glycerin has the function of moisturizing, ethanol is the preservative and solvent, and water is the solvent.

[0097] Precisely weigh the total alkaloids of Nuxebra chinensis and dissolve in ethanol, add oleic acid, propylene glycol, glycerin; add appropriate amount of water to 100ml. It can be used as a liniment or paint by putting it into a packaging bottle; it can be used as a spray by putting it into an aerosol bottle with a special spray device; absorb the medicinal liquid with a special dressing, seal it and use it as a wet compress.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a preparation formulation for an externally applied liquid preparation prepared from total strychnos alkaloids, and preparation thereof. The preparation formulation is prepared from the total strychnos alkaloids and auxiliary materials such as a transdermal sorbefacient, a solvent, a humectant and an antiseptic according to certain proportion. The externally applied liquid preparation of the total strychnos alkaloids comprises a pharmaceutically described externally applied liquid preparation such as a spraying agent, a wet application, a liniment or a pigmentum, and is used for treating diseases such as injuries from falls, carbuncle-abscess pain, rheumatic obstinate paralysis, rheumatoid arthralgia and anesthesia and paralysis. The preparation can overcome the defect that people are easy to be poisoned when orally taking strychnos. As proved by research results, the preparation is safe and effective, is convenient and comfortable to use, has small skin irritation and low production cost, is easy to be accepted by patients, and can generate good social benefit and economic benefit.

Description

technical field [0001] The invention relates to a liquid external preparation prepared from total alkaloids of strychnium. Background technique [0002] Nuxychia is a species recorded in the 2005 edition of the Pharmacopoeia. Its nature and flavor are bitter, cold, and highly toxic. It returns to the liver and spleen meridian. Swelling and pain, rheumatic paralysis, rheumatoid joint pain, numbness and paralysis and other diseases. Strychnine containing strychnine, strychnine, strychnine, strychnine, pseudo strychnine, pseudo strychnine, 4-hydroxy strychnine, strychnine Nitrogen oxides, strychnine nitrogen oxides, ecaine, 4-hydroxy 3-methyl strychnine and other alkaloids, in addition, it also contains fatty oil, protein, chlorogenic acid, strychnine, etc. . The main active ingredients are strychnine and strychnine, and the Pharmacopoeia stipulates that the content of strychnine in the strychnine is 1.2-2.2%, and the content of strychnine is not less than 0.8%. Nuxychia sh...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/56A61K9/12A61K9/70A61K9/00A61K47/44A61P17/02A61P25/00A61P29/00A61P19/00
Inventor 吴萍汤淮波胡海孙必强唐武杨占京
Owner XIANGTAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap