Biodegradable nontoxic amphipathic multi-block polyurethane material and preparation thereof

A polyurethane material, biodegradable technology, applied in the field of non-toxic amphiphilic multi-block polyurethane material and its preparation, can solve the problem of difficult drug release, targeting and long-term circulation, poor water solubility and high toxicity of anti-tumor drugs to achieve excellent surface activity, avoid phagocytosis, and inhibit protein adsorption

Active Publication Date: 2011-06-29
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these systems are essentially based on polyurethane material bodies, which fail to solve the problems of poor water solubility, high toxicity, poor selectivity and easy drug resistance of anti-tumor drugs, and it is difficult to achieve drug controlled release, targeting and long-term circulation.

Method used

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  • Biodegradable nontoxic amphipathic multi-block polyurethane material and preparation thereof
  • Biodegradable nontoxic amphipathic multi-block polyurethane material and preparation thereof
  • Biodegradable nontoxic amphipathic multi-block polyurethane material and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4、6、11、12

[0083] Add the polymer diol into a reaction kettle equipped with a stirrer, a thermometer and a nitrogen protection device, stir and heat up to 100°C, vacuum dehydrate for 120 minutes; then cool down to 50°C, add diisocyanate and solvent DMAc, and heat up to 65°C , prepolymerized under stirring and nitrogen protection for 60 minutes; then add a diol / amine chain extender (chain extender 1) with a molecular weight of <300 and 1‰ stannous octoate, and react at 70°C for 60 minutes; then add For the chain extender (chain extender 2) containing hydrophilic groups, continue the chain extension reaction for 120 minutes; finally add the monohydroxyl / amino end-capping agent, react for 60 minutes, then raise the temperature to 90°C, and keep it for 240 minutes. After the reaction solution is cooled, stop stirring and nitrogen protection, precipitate the product with excess ether, and obtain the product after drying. The weight ratio of the amount of solvent used in all examples to the ad...

Embodiment 5

[0085] Add the polymer diol into a reaction kettle equipped with a stirrer, a thermometer and a nitrogen protection device, stir and heat up to 110°C, vacuum dehydrate for 120 minutes; then cool down to 50°C, add diisocyanate and solvent DMAc, and heat up to 65°C , prepolymerization under stirring and nitrogen protection for 60 minutes; then add diol / amine chain extender (chain extender 1) with molecular weight <300 and 1‰ stannous octoate, and react at 70°C for 60 minutes; finally add Single hydroxyl / amino end-capping agent, after 60 minutes of reaction, the temperature was raised to 90°C and kept for 240 minutes. After the reaction solution is cooled, stop stirring and nitrogen protection, precipitate the product with excess ether, and obtain the product after drying. The weight ratio of the amount of solvent used in this example to the added reactant is 4:1, and the formulas of the remaining raw material monomers are shown in Table 1.

Embodiment 7

[0087] Add the polymer diol into a reaction kettle equipped with a stirrer, a thermometer and a nitrogen protection device, stir and heat up to 100°C, vacuum dehydrate for 100 minutes; then cool down to 50°C, add diisocyanate and solvent DMAc, and heat up to 65°C , prepolymerization under stirring and nitrogen protection for 60 minutes; then add a diol / amine chain extender (chain extender 1) with a molecular weight of <300 and 1‰ stannous octoate, and react at 70°C for 60 minutes; then lower the temperature After reaching room temperature, add a chain extender (chain extender 2) containing a hydrophilic group, slowly raise the temperature to 60°C and continue the chain extension reaction for 120 minutes; finally raise the temperature to 88°C and keep it for 300 minutes. After the reaction solution is cooled, stop stirring and nitrogen protection, and precipitate the product with excess ether to obtain a milky white or milky yellow solid, which can be obtained after drying. The...

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Abstract

The invention provides a biodegradable nontoxic amphiphilic multi-block polyurethane material which is formed by alternately copolymerize soft segments composed of polymer diol and hard segments composed of diisocyanate and a chain extender. Weight-average molecular weight of the biodegradable nontoxic amphiphilic multi-block polyurethane material is 5,000-100,000. The invention further provides a method for preparing the biodegradable nontoxic amphiphilic multi-block polyurethane material. The polyurethane material has a unique multi-block structure and amphiphilicity, can form a stable self-assembly micellar structure in water and easily introduces active sites at a main chain, a side chain and chain ends of polyurethane for molecular modification, and structure and performance of the polyurethane material is controllable. In addition, the polyurethane material has good biocompatibility and biodegradability with nontoxic degradation products, thus having wide application prospect inthe biomaterial field, especially in the field of polymer drug and gene delivery fields.

Description

technical field [0001] The invention belongs to the technical field of polyurethane materials and their preparation, and in particular relates to a biodegradable nontoxic amphiphilic multi-block polyurethane material and a preparation method thereof. Background technique [0002] With the rapid development of biodegradable polymer material science, cell and molecular biology, and pathology, tumor chemotherapy, gene therapy, and treatment of other diseases have also made great progress. Especially in the past few decades, scientists have extensively researched and developed a variety of drug delivery systems (DDS) to solve the shortcomings of many drugs such as solubility, poor stability and toxicity, so as to further improve the therapeutic effect and promote Its clinical application research (Wang, Y.; Gao, S.; Ye, W.H.; Yoon, H.S.; Yang, Y.Y. Nat. Mater. 2004, 5, 791. Geng, Y.; Dalhaimer, P.; Cai, S. ; Tsai, R.; Tewari, M.; Minko, T.; Desher, D. Nature nanotechnology 2007...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/72C08G18/42C08G18/48
Inventor 谭鸿丁明明傅强李洁华王志高张笑晴付晓婷张琴
Owner SICHUAN UNIV
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