Antibacterial argentum-carried hydroxylapatite/carbon nanotube composite artificial bone and preparation thereof

A composite technology of silver-loaded hydroxyapatite and carbon nanotubes, which is applied in prosthesis, medical science, etc., can solve problems such as death and body poisoning, and achieve the effects of preventing re-infection, accelerating healing, and strong mechanical properties

Inactive Publication Date: 2009-09-16
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, scientific research shows that excessive heavy metal elements can lead to poisoning of the body and even death

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Weigh 5g of hydroxyapatite / carbon nanotube powder (the mass fraction of carbon nanotubes is 5%), add it into 100mL of deionized water, and oscillate with ultrasonic waves for 30min to form a stable suspension;

[0027] 2) Weigh 1g of silver nitrate and add it to 100mL of deionized water to make a silver nitrate solution;

[0028] 3) Measure 10 mL of the silver nitrate solution obtained in step 2), and slowly add it to the suspension described in step 1) under mechanical stirring;

[0029] 4) Stir the suspension obtained in step 3) at 20° C. for 60 min, centrifuge the obtained precipitate, wash with alcohol, and dry to obtain a silver-loaded hydroxyapatite / carbon nanotube composite powder;

[0030] 5) The composite powder obtained in step 4) is hot-pressed and sintered (protected under nitrogen, kept at 1100°C for 20 minutes, and the heating rate is 40°C / min), and the antibacterial silver-loaded hydroxyapatite / carbon nanotube composite artificial bone can be obtained....

Embodiment 2

[0032] 1) Weigh 5g of hydroxyapatite / carbon nanotube powder (mass fraction of carbon nanotubes is 10%), add it into 100mL of deionized water, and oscillate with ultrasonic waves for 30min to form a stable suspension;

[0033] 2) Weigh 1g of silver nitrate and add it to 100mL of deionized water to make a silver nitrate solution;

[0034] 3) Measure 50 mL of the silver nitrate solution obtained in step 2), and slowly add it to the suspension described in step 1) under mechanical stirring;

[0035] 4) Stir the suspension obtained in step 3) at 30° C. for 60 min, centrifuge the obtained precipitate, wash with 75% (v / v) ethanol, and dry to obtain a silver-loaded hydroxyapatite / carbon nanotube composite powder;

[0036] 5) The composite powder obtained in step 4) is hot-pressed and sintered (protected under nitrogen, kept at 1100°C for 20 minutes, and the heating rate is 40°C / min), and the antibacterial silver-loaded hydroxyapatite / carbon nanotube composite artificial bone can be ob...

Embodiment 3

[0038] 1) Weigh 5g of hydroxyapatite / carbon nanotube powder (mass fraction of carbon nanotubes is 15%), add it into 100mL of deionized water, and oscillate ultrasonically for 30min to form a stable suspension;

[0039] 2) Weigh 1g of silver nitrate and add it to 100mL of deionized water to make a silver nitrate solution;

[0040] 3) Measure 20 mL of the silver nitrate solution obtained in step 2), and slowly add it to the suspension described in step 1) under mechanical stirring;

[0041] 4) stirring the suspension obtained in step 3) at 40° C. for 80 min, centrifuging the obtained precipitate, washing with alcohol, and drying to obtain a silver-loaded hydroxyapatite / carbon nanotube composite powder;

[0042]5) The composite powder obtained in step 4) is hot-pressed and sintered (protected under nitrogen, kept at 1100°C for 20 minutes, and the heating rate is 40°C / min), and the antibacterial silver-loaded hydroxyapatite / carbon nanotube composite artificial bone can be obtained...

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Abstract

The invention discloses an antibacterial argentum-carried hydroxylapatite / carbon nanotube composite artificial bone and a preparation method thereof. Hydroxylapatite / carbon nanotube composite powder prepared by an in situ synthesis method is used as a carrier, and argentum-carried hydroxylapatite / carbon nanotube composite powder is obtained through ion exchange and ion adsorption; and the argentum-carried hydroxylapatite / carbon nanotube composite powder is used as a raw material, and the antibacterial argentum-carried hydroxylapatite / carbon nanotube composite artificial bone is prepared by a hot pressed sintering method. The artificial bone obtained by the method has obvious antibacterial effect, and not only maintains stronger mechanical property and good biological performance of the hydroxylapatite / carbon nanotube composite artificial bone, but also can treat and prevent infection so as to avoid multiple surgeries.

Description

technical field [0001] The invention relates to a composite artificial bone and a preparation method thereof, in particular to an antibacterial silver-loaded hydroxyapatite / carbon nanotube composite artificial bone and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] For a long time, the development of ideal biomaterials to replace autologous bone for bone defect repair has been an important topic in the fields of medicine and materials science. Hydroxyapatite (HAp) has the same inorganic composition and similar structure as natural bone, so it has good bioactivity and biocompatibility, and has been widely used clinically as a bone defect repair and bone filling plastic material. However, as an inorganic non-metallic material, hydroxyapatite has the commonality of this type of material: low strength and toughness. Carbon nanotubes have unique metal or semiconductor electrical conductivity, strong mechanical strength...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/54C04B35/622C04B35/447C04B35/52A61L27/12A61L27/08A61L27/04
Inventor 卢志华孙康宁孙晓宁
Owner SHANDONG UNIV
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