Novel medical compound being capable of synergetically suppressing growth of tumors

A composition and drug technology, applied in the field of new pharmaceutical compositions capable of synergistically inhibiting tumor growth
CN101554472AInactive Publication Date: 2009-10-14MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Publication Date
2009-10-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a novel synergetic medical compound being capable of suppressing growth of tumors, which consists of an enediyne drug and an alkylated chemotherapeutic drug, i.e. lidamycin and temodar; relevant researches prove that the medical compound can synergetically resist the multiplication of the tumor cells, induce apoptosis and suppress angiogenesis; in vivo test has an obvious curative effect on nude mice transplanted tumor of the human neuroglioma U87 cells. The medical compound has an enhanced function of suppressing the growth of tumors and angiogenesis in tumor tissues, thus displaying a synergetic tumor suppressing effect and having good application prospect.
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Description

Technical field:

[0001] The invention relates to the application of a novel pharmaceutical composition capable of synergistically enhancing and inhibiting tumor growth. Background technique:

[0002] Tumor is a frequently-occurring and common disease that threatens human health. Glioma is the most common primary brain tumor in adults and is very harmful. Although surgery, radiotherapy and chemotherapy have made great progress, in fact, only for nervous system tumors, including glioma patients, the survival rate and quality of life have not changed significantly in the past ten years. At present, the main chemotherapy drugs used to treat glioma are nitrosoureas or alkylating agents, but gliomas also have drug resistance to these drugs [N Engl JMed (New England Medicine), 2005, 352(10): 987-996], the clinical treatment of glioma is mostly a combination of radiotherapy and chemotherapy, and the main chemotherapeutic drugs are single or single or mainly nitrosoureas or alkylati...

Claims

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