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Preparation method of superparamagnetic Fe3O4 nano-particles

A technology of ferric tetroxide and nanoparticles, which is applied in the fields of nanostructure manufacturing, iron oxide/hydroxide, nanotechnology, etc., can solve the problems of only being dispersed in non-polar solvents, unsuitable for biomedical fields, and expensive. , to achieve the effect of easy control, convenient combination and reasonable design

Inactive Publication Date: 2009-10-21
SHANDONG UNIV
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Problems solved by technology

The synthesis method of high-quality superparamagnetic ferroferric oxide nanoparticles is mainly the metal-organic compound of thermal decomposition of iron in high-boiling organic solvents. Most of this method uses carbonyl iron ([Fe(CO) 5 ]), iron triacetylacetonate ([Fe-(acac) 3 ]), copper iron reagent salt ([Fe(Cup) 3 ]) and organometallic compounds such as ferric oleate as iron sources, these metal organic compounds of iron and the high boiling point organic solvents used are very toxic and very expensive, and the products can only be dispersed to In non-polar solvents, not suitable for use in biomedical fields

Method used

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Embodiment 1

[0020] Embodiment 1: the preparation method of superparamagnetic iron ferric oxide nanoparticles, the steps are as follows:

[0021] 1) Weigh 0.3g of anhydrous FeCl 3 Dissolve 2.0g of arginine in 10mL of water, then add 10mL of glycerin, and mix evenly by ultrasonication;

[0022] 2) Place the homogeneous mixture obtained in step (1) in a stainless steel reaction kettle lined with polytetrafluoroethylene, close the reaction kettle, and react at a constant temperature of 200°C for 6 hours. After the reaction is completed, naturally cool to room temperature, and the obtained The product is washed three times with water at room temperature, then magnetically separated, and the product is dispersed in water to prepare a suspension of nano ferric oxide. Reaction under the above-mentioned constant temperature condition means that the reaction kettle is placed in an oven capable of precise temperature control.

[0023] figure 1 X-ray diffraction spectrum of the ferric oxide nanopa...

Embodiment 2

[0027] The preparation method of superparamagnetic ferric iron tetroxide nanoparticles has the same steps as Example 1, except that the reaction is carried out at a constant temperature of 200° C. for 2 hours.

Embodiment 3

[0029] The preparation method of superparamagnetic ferric iron tetroxide nanoparticles, the steps are the same as in Example 1, the difference is that the reaction is carried out at a constant temperature of 200° C. for 12 hours.

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Abstract

The invention relates to a preparation method of superparamagnetic Fe3O4 nano-particles, belonging to the field of inorganic nano material preparation. The method is characterized in that the method adopts nontoxic glycerin, arginine, water and ferric iron as raw materials to synthesize high-quality superparamagnetic nano Fe3O4. The method features reasonable design of technical proposal, simple operation, easy control of reaction, good repeatability, no pollution and good safety. The prepared Fe3O4 nano-particles have high saturated magnetic intensity and tiny coercivity, can be conveniently combined with antibodies, are excellent super-magnetic nano materials and can be widely applied to the field of biomedicines.

Description

technical field [0001] The invention relates to a preparation method of superparamagnetic ferric iron tetroxide nanoparticles, which belongs to the field of preparation of inorganic nanometer materials. Background technique [0002] Due to its excellent properties, Fe3O4 nanoparticles have been widely used in the fields of magnetic fluid, catalysis, targeted drug delivery, immobilized enzymes, nuclear magnetic resonance imaging, data storage, and environmental governance. In most biomedical applications, ferroferric oxide nanoparticles with diameters in the size range of 10-20 nanometers exhibit the best properties. Each ferroferric oxide nanoparticle becomes a single magnetic domain, which exhibits superparamagnetic. A single magnetic particle has a very large fixed magnetic moment, like a very large paramagnetic atom, has a fast response to an applied magnetic field and has negligible coercivity (residual magnetization) and coercivity (reducing the magnetization to zero)....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/08B82B3/00H01F1/34
Inventor 占金华来永超杨敏
Owner SHANDONG UNIV
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