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Oral arginine ibuprofen liquid preparation
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A technology of arginine ibuprofen and liquid preparations, applied in anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc., to reduce gastrointestinal irritation, fast absorption, and easy dosage Effect
Inactive Publication Date: 2009-10-28
TIANJIN MEDICAL UNIV
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Ibuprofen syrup has been reported and applied both at home and abroad, but the arginine ibuprofen oral liquid preparation has not been reported and applied yet. Compared with the ibuprofen oral liquid preparation reported in the literature, this preparation has no alcohol and NaHCO 3 Features such as alkaline substances, rapid absorption, fast onset of action, less irritating to the gastrointestinal tract
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Embodiment 1
[0042] Every 1000ml arginine ibuprofen syrup, weigh materials according to the following formula:
[0048] The arginine ibuprofen syrup of the present invention is prepared by the raw and auxiliary materials taken according to the following steps:
[0049] Take 37g of arginine ibuprofen and 2g of sodium benzoate, add 100ml of distilled water to dissolve, add 0.5ml of essence, add simple syrup to 1000ml, mix well, and get ready.
Embodiment 2
[0051] Every 1000ml arginine ibuprofen syrup, weigh materials according to the following formula:
[0072] The arginine ibuprofen oral solution of the present invention is prepared by the raw and auxiliary materials taken according to the following steps:
[0073] 1. Dissolve arginine ibuprofen and aspartame in 100ml of water, then add food coloring to dissolve;
[0074] 2. Take agar, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate and add 800ml of water, heat to fully dissolve, and filter while hot;
[0075] 3. Add 1 to 2 and stir evenly, then add essence, add water to 1000ml, stir evenly, and you get it.
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Abstract
The invention relates to an oral arginineibuprofen liquid preparation which is characterized in that receivable carrier on pharmacy contains arginineibuprofen with effective dose, and also contains proper medicine composition of pharmaceutical excipient. The pharmaceutical excipient includes one or the combination of a plurality of sweetening agent, mucilage, reodorant, preservative, stabilizing agent and colorant. In the arginineibuprofen liquid preparation, medicine is dispersed in medium by molecular state, has large dispersion degree and fast absorption, and can rapidly bring the medicine effect. The arginine ibuprofen liquid preparation is convenient for taking, is easy to divide dose, is especially suitable to special crowds having difficulty to swallow solid preparations, such as children, or senile patients and the like, and can reduce the gastrointestinal tractstimulation effect caused by overhigh local concentration after ibuprofen solid preparation is oral-administrated.
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Application Information
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