Hybrid artificial liver supporting system equipped with perforated brick type filling bracket type reactor

Abstract

The invention relates to a medical equipment and aims at providing a hybrid artificial liver supporting system equipped with a perforated brick type filling bracket type reactor. The system comprises a plasma separating part, a non-biological liver circulating part and a biological liver circulating part; the biological liver circulating part comprises a constant temperature air bath incubator which plays the role of heat preservation and an extracorporeal circulation pool, a plasma pump, a dissolved oxygen and temperature testing bottle and the perforated brick type filling bracket type reactor which are connected into a circulation system in sequence. The invention not only solves the problem that the bracket type reactor is lack of immune isolation and is insufficient for oxygen supply,but also makes up the defects that the hollow fiber type reactor has insufficient cell growing space and poor cell adhesion, is lack of three-dimensional growing environment and is easy to block semi-permeable membranes. The invention integrates the functions of oxygenation, immune isolation, three-dimensional culture and the like and has strong comprehensive performance, simple manufacturing technique, low cost and easy amplification. As the reactor of the system has the function of oxygenation, the system saves an oxygenator which generally needs to be equipped independently.

Description

Technical field [0001] The invention relates to a medical device, which is a hybrid artificial liver support system equipped with a porous brick-type filling support type reactor. Background technique [0002] Artificial liver support therapy has been recognized worldwide as one of the effective treatments for patients with severe hepatitis and liver failure. It includes three categories of non-biological, biological, and hybrid artificial livers, of which the latter two are the main international development directions. [0003] The hybrid artificial liver support system usually includes a plasma separation part, a non-biological liver circulation part and a biological liver circulation part in sequence, and the three parts are connected by pipeline interfaces. Among them, the biological liver circulation part is the main body, it is based on culturing liver cells, and the bioreactor is the core carrier, which has the functions of biosynthesis, transformation metabolism, detoxifi...

AI Technical Summary

Problems solved by technology

At present, the most clinical application is the hollow fiber reactor, which has the functions of immune isolation and oxygenation, and the cells are less sheared, but has the following disadvantages: 1. The traditional hollow fiber reactor has insufficient space for cell growth and uneven distribution. 2. It can only provide two-dimensional culture, but not three-dimensional culture; 3. The semi-permeable membrane barrier or collagen layer will affect the material exchange efficiency; 4. Cells grow on the surface of the fiber, so it is easy to block the fiber hole

But it has the following disadvantages: 1. There is a potential safety hazard of lack of immune isolation; 2. The oxygen supply of cells is insufficient; 3. The center and edge of the entire reactor support are prone to produce dead space and dead space; 4. Through a large number of supports The resistance is large, and the required perfusion intensity is high, which causes the cells to be subjected to a large shear force and is difficult to amplify

The existing reactors with good comprehensive performance in the world often have complex structures, high manufacturing process requirements, and high costs.

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