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Venlafaxine hydrochloride sustained-release tablet preparation and preparation method thereof

A technology for venlafaxine hydrochloride and sustained-release tablets, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of large fluctuations in blood drug concentration, large side effects, and rapid metabolism And other issues

Inactive Publication Date: 2009-11-25
上海医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although venlafaxine hydrochloride has a definite curative effect, due to the fast metabolism of the drug in the body, the common tablet or capsule specification can only be 25 mg when clinically used, while the daily effective dose is 75 mg when clinically used, which will make Patients take their medication more often per day
As a result, there are disadvantages such as large fluctuations in blood drug concentration and large side effects.

Method used

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  • Venlafaxine hydrochloride sustained-release tablet preparation and preparation method thereof
  • Venlafaxine hydrochloride sustained-release tablet preparation and preparation method thereof
  • Venlafaxine hydrochloride sustained-release tablet preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0060] Tablet formula: (made into 1000 tablets, each containing venlafaxine hydrochloride 75mg)

[0061]

[0062] Coating solution: aqueous dispersion of ethyl acrylate-methyl methacrylate copolymer

[0063] Preparation process: pass the above raw materials and supplements through 80-mesh sieve respectively, then mix evenly, directly compress into tablets, then coat with the above coating solution, and add talcum powder. Place the wrapped finished product at 40°C and keep it warm for 24 hours.

Embodiment 2

[0065] Tablet prescription: (made into 1000 tablets, each containing 75mg of venlafaxine hydrochloride)

[0066]

[0067] Coating solution: aqueous dispersion of ethyl acrylate-methyl methacrylate copolymer

[0068] Preparation process: pass the above raw materials and supplements through 80-mesh sieve respectively, then mix them evenly, make 16-mesh granules by dry method, compress into tablets, then coat with the above-mentioned coating solution, and add appropriate amount of talcum powder. Place the wrapped finished product at 40°C and keep it warm for 24 hours.

Embodiment 3

[0070] Tablet prescription: (made into 1000 tablets, each containing 75mg of venlafaxine hydrochloride)

[0071]

[0072] Coating solution: aqueous dispersion of ethyl acrylate-methyl methacrylate copolymer

[0073] Preparation process: pass the above raw materials and supplements through 80-mesh sieve respectively, then mix them evenly, make 16-mesh granules by wet method, dry them, add the prescribed amount of magnesium stearate, mix them evenly, press into tablets, then coat with the above coating solution, and Add talc. Place the wrapped finished product at 40°C and keep it warm for 24 hours.

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Abstract

The invention discloses a venlafaxine hydrochloride sustained-release tablet preparation which comprises venlafaxine hydrochloride, framework material, diluent, lubricant, adhesive and coating material. The experiments demonstrate that the venlafaxine hydrochloride sustained-release tablet achieves better sustained-release effect, can reduce the dosing frequency and is convenient for the patients to use. The invention also provides a preparation method thereof.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a novel antidepressant venlafaxine hydrochloride sustained-release tablet preparation and a preparation method thereof. Background technique [0002] Venlafaxine is a novel phenethylamine derivative. Its mechanism of action is different from that of tricyclic antidepressants and newer selective serotonin reuptake inhibitors in that it exerts antidepressant effects through inhibition of norepinephrine and serotonin reuptake and weak inhibition of dopamine reuptake. Depressive effect, no inhibitory effect on monoamine oxidase, no affinity with cholinergic, histaminergic, adrenergic and other receptors, so there are no adverse reactions related to these receptors, such as sedation, dry mouth, constipation, urinary retention and blurred vision . Venlafaxine is a new type of antidepressant with rapid onset, good tolerance, and good short-term and long-term therapeutic effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/135A61K47/36A61P25/24
Inventor 黄君勤苏恩云曾垂宇
Owner 上海医药科技发展有限公司
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