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Rutin-arabic-gum-gelatin slowreleasing microspheres and preparation thereof

A technology of gum arabic and slow-release microspheres, which can be used in capsule delivery, microcapsules, and pharmaceutical formulations. It can solve the problems of high cost and difficult industrial production, and achieve the effects of avoiding extremely poor solubility, good stability, and rapid onset of action

Inactive Publication Date: 2009-11-25
张辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method can effectively improve the solubility of rutin in water, but unfortunately, the above methods are difficult to realize industrial production due to problems such as cost.

Method used

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  • Rutin-arabic-gum-gelatin slowreleasing microspheres and preparation thereof
  • Rutin-arabic-gum-gelatin slowreleasing microspheres and preparation thereof
  • Rutin-arabic-gum-gelatin slowreleasing microspheres and preparation thereof

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Experimental program
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Effect test

Embodiment 1

[0025] Study on the Preparation of Rutin-Arabic Gum-Gelatin Sustained-release Microspheres

[0026] 1. Implementation method

[0027] (1) Instruments: timing electric stirrer, constant temperature water bath, drying oven, ultraviolet spectrophotometer, microscope, electronic balance, induction cooker, etc.

[0028] (2) Reagents: rutin, rutin standard, gelatin, gum arabic, acetic acid, formaldehyde, absolute ethanol, etc.

[0029] (3) Factors and levels: In order to optimize the preparation process, according to the results of the preliminary test, the mass ratio of the capsule material to the capsule core, the pH value of the capsule, the temperature of the capsule and the curing time are determined to be the factors that affect the microcapsule formation and encapsulation efficiency. The main factors, so 3 levels are taken for each, according to the three-level table L of the orthogonal test 9 (3 4 ) to carry out experiments, and use the encapsulation efficiency as an eval...

Embodiment 2

[0069] The preparation method of rutin-gum arabic-gelatin sustained-release microspheres:

[0070] ① Take 3g of gum arabic and 3g of gelatin respectively, add 97g of distilled water to each, put them in a water bath to make a solution of 3% gum arabic and 3% gelatin by mass ratio, put them in a water bath at 50°C, and heat them to dissolve 20 minutes, keep warm, set aside;

[0071] ② Take another 1g of rutin that has been finely ground and passed through a 200-mesh sieve. After accurate weighing, add the above-mentioned gelatin solution, put it in a water bath at 50°C and mix evenly, and add the above-mentioned gum arabic solution while stirring. The speed of the glue solution controls the mass ratio of the capsule material and the capsule core, and the best choice is 6: 1 to obtain a mixed solution; the so-called capsule material is gum arabic and gelatin, and the so-called capsule core is rutin;

[0072] 3. Adjust the temperature of the water bath so that the mixed solution...

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Abstract

The invention relates to a rutin-arabic-gum slow-release gelatin microspheres and preparation thereof, belonging to an assistant curing medicine of microorganism infection. The preparation method comprises using rutin as material, adding natural polymer materials gum Arabic and gelatin as the base material frame for the preparation of the microsphere; the weight ratio is that rutin: Arabic: gum=1: 3: 3. The rutin-arabic-gum releasing gelatin microspheres prepared in the invention effectively avoids the characteristic of worst solubility of the rutin in the water to obtain the characteristic of fast effect, high bioavailability, little poisonous side effect and convenient prescription and so on.

Description

technical field [0001] The present invention relates to a novel pharmaceutical preparation of rutin, in particular to a rutin-gum arabic-gelatin sustained-release microsphere and a preparation method thereof. Background technique [0002] Rutin, also known as rutin and purple quercetin, is a flavonoid compound with a wide range of sources. Rutin widely exists in the plant kingdom, almost all Rutaceae and Heather plants contain it, especially the Rutaceae Rutaceae, the flower buds (Sophora japonica), fruit (Sophora japonica), Polygonaceae plants The content of buckwheat, Hypericum family plant Honghan whole grass, Rhamnaceae plant guangzhigou catecha, and Echinaceae plant wild sycamore leaf are relatively rich, which can be used as raw materials for extracting rutin. In addition, it also exists in holly plants such as holly plants, forsythia plants in Oleaceae plants, sophora japonicus plants in leguminous plants, and plants such as tobacco, jujube, apricot, orange peel and ...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K9/52A61K47/42A61K47/36A61K31/7048A61P9/12A61P7/04A61P3/10A61P3/06A61P31/04
Inventor 张辉
Owner 张辉
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