Sub-microemulsion used for intravenous injection of polyene yew alcohol phospholipid composite and preparation method thereof
A technology of docetaxel phospholipid and paclitaxel phospholipid, which is applied in the field of medicine to achieve the effects of good stability, good physiological compatibility, and reduced dosage of excipients
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Embodiment 1
[0043] Docetaxel 100mg
[0044] Soy Lecithin for Injection 1.2g
[0045] Absolute ethanol 5mL
[0046] Soybean oil for injection 5.0g
[0047] Add water for injection to 100mL
[0048] method:
[0049] 1. Dissolve docetaxel and phospholipids in absolute ethanol, stir at room temperature for 2 hours to compound, and prepare the docetaxel-phospholipid complex.
[0050] 2. Preparation of the oil phase: After compounding, add soybean oil for injection, stir and mix evenly, evaporate the organic solvent under reduced pressure to dry up, use it as the oil phase, and heat it to 70°C to keep it warm for later use.
[0051] 3. Preparation of the water phase: Take an appropriate amount of water for injection and heat it to 70°C as the water phase.
[0052] 4. Drop the water phase into the oil phase at a constant temperature of 70°C, stir at a high speed to form colostrum, then adjust the pH value to 4-9, set the volume to 100mL, and then pass the colostrum through a high-pressure h...
Embodiment 2
[0054] Docetaxel 500mg
[0055] Hydrogenated Phospholipids 1.5g
[0056] Diethyl ether 10mL
[0057] V E 0.1g
[0058] MCT 10.0g
[0059] Sodium Cholesterol Sulfate 1g
[0060] Tween 80 0.1g
[0061] Glycerol 2.25g
[0062] Add water for injection to 100mL
[0063] Wherein, the compounding time is 1 h, and other steps are the same as in Example 1, and the docetaxel-phospholipid complex submicroemulsion of the present invention is obtained.
Embodiment 3
[0065] Docetaxel 1.0g
[0066] Soy Lecithin 3.0g
[0067] Dichloromethane 10mL
[0068] Cholesterol 0.3g
[0069] Soybean oil for injection 20.0g
[0070] Poloxamer 188 1g
[0071] Glycerol 2.25g
[0072] Add water for injection to 100mL
[0073] The other steps are the same as in Example 1 to obtain the multiline paclitaxel-phospholipid complex submicroemulsion of the present invention.
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