Multiple mesh nanometer carbon-hydroxyapatite composite material and preparation method thereof

A nano-hydroxyapatite and hydroxyapatite technology, which is applied in the field of nanocomposite material science and engineering, can solve the problems of uneven dispersion of carbon nanotubes, poor performance consistency, and agglomeration of carbon nanotubes, and is beneficial to large-scale production. Industrialized production, low cost, and the effect of enhancing interfacial adhesion

Inactive Publication Date: 2013-01-09
HUNAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the shortcomings of the existing HA-carbon biocomposite materials and technologies, such as poor performance consistency, complicated preparation process, uneven dispersion of carbon nanotubes, and agglomeration of carbon nanotubes. Biocomposite materials with excellent biological and mechanical properties --- a large amount of nano-network carbon-hydroxyapatite biocomposites, and used in clinical medicine as hard tissue repair and replacement materials

Method used

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  • Multiple mesh nanometer carbon-hydroxyapatite composite material and preparation method thereof
  • Multiple mesh nanometer carbon-hydroxyapatite composite material and preparation method thereof
  • Multiple mesh nanometer carbon-hydroxyapatite composite material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] 1. Weigh 0.7100g of phosphorus pentoxide, dissolve the weighed phosphorus pentoxide into 20ml of absolute ethanol under room temperature and medium-speed magnetic stirring, and keep stirring for 1h to obtain solution A;

[0042] 2. Accurately weigh 3.9412 g of calcium nitrate tetrahydrate with an electronic analytical balance, dissolve the weighed calcium nitrate tetrahydrate into 20 ml of absolute ethanol at room temperature and under medium-speed magnetic stirring, and continue stirring for 1 hour to obtain solution B;

[0043] 3. Weigh 0.1860g of CNTs into a beaker, add 20ml of absolute ethanol to the beaker, place it in an ultrasonic disperser and disperse it ultrasonically for 2 hours while passing in hydrogen peroxide, so that the CNTs are evenly dispersed, and a C solution is obtained;

[0044] 4. Under the condition of medium-speed magnetic stirring, slowly inject solution C into solution B successively, and keep stirring for 20 minutes. Then slowly inject soluti...

Embodiment 2

[0048] 1. Weigh 1.4200g of phosphorus pentoxide, dissolve the weighed phosphorus pentoxide into 20ml of absolute ethanol under room temperature and medium-speed magnetic stirring, and keep stirring for 1h to obtain solution A;

[0049] 2. Accurately weigh 7.8824 g of calcium nitrate tetrahydrate with an electronic analytical balance, dissolve the weighed calcium nitrate tetrahydrate into 20 ml of absolute ethanol at room temperature and under medium-speed magnetic stirring, and continue stirring for 1 hour to obtain solution B;

[0050] 3. Weigh 0.5906g of CNTs and put them into a beaker, add 20ml of absolute ethanol into the beaker, put it in an ultrasonic disperser and disperse it ultrasonically for 2 hours while passing in hydrogen peroxide, so that the CNTs are evenly dispersed, and a C solution is obtained;

[0051] 4. Under the condition of medium-speed magnetic stirring, slowly inject solution C into solution B successively, and keep stirring for 20 minutes. Then slowly ...

Embodiment 3

[0055] 1. Weigh 0.7100g of phosphorus pentoxide, dissolve the weighed phosphorus pentoxide into 20ml of absolute ethanol under room temperature and medium-speed magnetic stirring, and keep stirring for 1h to obtain solution A;

[0056] 2. Accurately weigh 3.9412 g of calcium nitrate tetrahydrate with an electronic analytical balance, dissolve the weighed calcium nitrate tetrahydrate into 20 ml of absolute ethanol at room temperature and under medium-speed magnetic stirring, and continue stirring for 1 hour to obtain solution B;

[0057] 3. Weigh 2.2000g of CNTs into a beaker, add 20ml of absolute ethanol into the beaker, place it in an ultrasonic disperser and disperse it ultrasonically for 2 hours while passing in hydrogen peroxide, so that the CNTs are evenly dispersed, and a C solution is obtained;

[0058] 4. Under the condition of medium-speed magnetic stirring, slowly inject solution C into solution B successively, and keep stirring for 20 minutes. Then slowly inject solu...

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Abstract

The invention relates to a multiple mesh nanometer carbon-hydroxyapatite composite material and a preparation method thereof. In the process of preparing the composite material, carbon nanotubes purified and dispersed by hydrogen peroxide are added to raw materials for preparing nanometer hydroxyapatite; during the reaction of preparing the nanometer hydroxyapatite, the carbon nanotubes are compounded with the generated nanometer hydroxyapatite to obtain composite sol; the obtained composite sol is sintered at a temperature of 750 to 800 DEG C after being dried to obtain the composite material. The multiple mesh nanometer carbon-hydroxyapatite composite material is characterized in that the carbon nanotubes in the composite material form a mesh structure, and bone-like hydroxyapatite crystal phase coats on the surfaces of the carbon nanobubes and in a network gap built by the carbon nanotubes in the mode of nanometer crystal grains; and the weight content of the carbon nanotubes in the composite material is more than 5 percent and less than or equal to 30 percent. The composite material prepared by the method has no toxicity and harm, good bioactivity and biocompatibility and highintensity compared with pure hydroxyapatite, and Young's modulus is more matched with natural bones of a human body.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite material science and engineering, in particular to a novel artificial hard tissue medical implant material and a preparation method thereof. Background technique [0002] Due to the increase of accidental trauma, the continuous emergence of difficult bone diseases and the aging of the social population, the demand for medical materials for human hard tissues is increasing all over the world. For the medical requirements of hard tissue repair and replacement, a variety of artificial hard tissue implant materials have been developed, mainly including metals (such as titanium and its alloys, stainless steel), polymers, ceramics, and their composite systems. Among them, the hydroxyapatite-carbon biocomposite (HA-C) combines the good biocompatibility of hydroxyapatite (HA) (with a crystal structure and chemical composition similar to biological bones, teeth, etc.) and carbon ( C) has the advanta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/56A61K6/033A61K6/027A61L27/08A61L27/12A61K6/838
Inventor 何莉萍陈大川
Owner HUNAN UNIV
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