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Nanometer microsphere or hollow sphere of casein or casein-polyacrylic acid compound and preparation method and application thereof

A technology of polyacrylic acid and nano-microspheres, which is applied to the preparation of microspheres, microcapsule preparations, and medical preparations of non-active ingredients. Degradability, good biocompatibility, and the effect of not being immune to the body

Inactive Publication Date: 2010-02-17
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, natural polymers have many fatal weaknesses, such as being rejected by the human body due to their strong physiological activity, it is difficult to evaluate their degradation rate in vivo, and the mechanical properties of natural polymers are poor.
Due to these shortcomings, the application of natural polymers is limited

Method used

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  • Nanometer microsphere or hollow sphere of casein or casein-polyacrylic acid compound and preparation method and application thereof
  • Nanometer microsphere or hollow sphere of casein or casein-polyacrylic acid compound and preparation method and application thereof
  • Nanometer microsphere or hollow sphere of casein or casein-polyacrylic acid compound and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Add 40ml of distilled water, 0.08g of casein, and 0.4g of acrylic acid into a 100ml three-neck flask, and then heat it to 90°C. g. As the reaction progresses, the color of the system gradually changes from colorless to light blue to milky blue. At this time, remove the heat source, stop stirring, cool, filter, and use analytically pure hydrochloric acid and distilled water to adjust pH=3 for dialysis Media dialysis, adding 250ml of water each time, changing the water 20 times, dialysis to remove the small inorganic salt molecules and unreacted monomers in the system, and then the composite nano-microspheres can be obtained. 170nm, particle size distribution see Picture 1-1 , the transmission electron microscope photo see figure 2 . Take out the above liquid, add 40ul of 25% glutaraldehyde or 0.04g of calcium sulfate dihydrate to cross-link, react at 40°C for 24 hours and then filter, then use analytically pure hydrochloric acid and distilled water to prepare a dialy...

Embodiment 2

[0048] Add 40ml of distilled water, 0.08g of casein, and 0.6g of acrylic acid into a 100ml three-necked flask, and then heat it to 90°C. g, as the reaction progresses, the color of the system gradually changes from colorless to light blue to milky blue. At this time, remove the heat source, stop stirring, cool, filter, and dialyze to remove small inorganic salt molecules and unreacted The monomer can be used to obtain composite nano-microspheres, and the obtained nanoparticles are stored in a refrigerator at 4°C. Take out the above liquid, add 40 ul of 25% by mass glutaraldehyde or 0.04 g of calcium sulfate dihydrate for cross-linking, react at 40°C for 24 hours and then filter, if the nano-microspheres are dialyzed in water with pH=3, cross-linking can be obtained. The nano-microsphere 0.52 gram of the casein-polyacrylic acid composite of linking, average particle diameter is 210nm, and the content of polyacrylic acid is 85% in the composite microsphere; If this nano-microsph...

Embodiment 3

[0050] Add 40ml of distilled water, 0.12g of casein, and 0.6g of acrylic acid into a 100ml three-necked flask, and then heat it to 90°C. g, as the reaction progresses, the color of the system gradually changes from colorless to light blue to milky blue. At this time, remove the heat source, stop stirring, cool, filter, and dialyze to remove small inorganic salt molecules and unreacted The monomer can be used to obtain composite nano-microspheres, and the obtained nanoparticles are stored in a refrigerator at 4°C. Take out the above liquid, add 60ul of 25% by mass glutaraldehyde or 0.06g of calcium sulfate dihydrate to cross-link, react at 40°C for 24 hours and then filter, if the nano-microspheres are dialyzed in water with pH=3, cross-linking can be obtained. 0.6 grams of nano-microspheres of the casein-polyacrylic acid composite, the average particle diameter is 190nm, and the content of polyacrylic acid in the composite microspheres is 82%; if this nano-microsphere system i...

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Abstract

The invention relates to a nanometer microsphere or a nanometer hollow sphere of casein or casein-polyacrylic acid compound, and a nanometer microsphere or a nanometer hollow sphere of cross-linking casein, wherein the nanometer microsphere or the nanometer hollow sphere of the casein or casein-polyacrylic acid compound consists of a compound of casein and polyacrylic acid, and the average grain diameter of the nanometer microsphere or the nanometer hollow sphere is 170-370nm; the nanometer microsphere or the nanometer hollow sphere of cross-linking casein consists of cross-linking casein, andthe average grain diameter of the nanometer microsphere or the nanometer hollow sphere is 240-500nm. The nanometer microsphere or the nanometer hollow sphere of cross-linking casein has good biocompatibility and biodegradability without causing organism immunoreaction; degradation products of the nanometer microsphere or the nanometer hollow sphere of cross-linking casein can be absorbed and metabolized by a human body and has the treatment action, nutritive efficiency and the like on the human body, and therefore, the nanometer microsphere or the nanometer hollow sphere of cross-linking casein can be used as a carrier of drugs. The invention discloses a preparation method of the nanometer microsphere or the nanometer hollow sphere of the casein or casein-polyacrylic acid compound, and apreparation method of the nanometer microsphere or the nanometer hollow sphere of cross-linking casein.

Description

technical field [0001] The invention relates to a casein nanomaterial, its preparation method and its application as a drug carrier Background technique [0002] The drug delivery system is to combine drugs or other bioactive substances with carrier materials so that the drugs can be released into the environment at a certain rate or transported to specific target tissues within a certain period of time through diffusion, etc., and have an effect on the health of the body. , mainly consists of two parts: drug and carrier. Nano-drug carriers refer to various nanoparticles in which drugs are dissolved or dispersed, such as nanoliposomes, polymer nanocapsules, nanospheres, nanomicelles, etc., usually made of natural or synthetic polymer materials. There are many preparation methods for nano-drug carriers, among which cross-linking method, precipitation / coagulation method, solvent evaporation method, spray drying method, porous centrifugation method, salting-out method and ultr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K47/32A61K9/14A61P35/00B01J13/14
Inventor 蒋锡群刘成杰
Owner NANJING UNIV
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