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Composite of natural macromolecule or amphiphilic grafting copolymer of water-soluble derivant and nanometer iodine and preparation method thereof

A technology of natural polymers and graft copolymers, which is applied in the compound field of amphiphilic graft copolymers and iodine, and can solve problems such as difficulties and immature iodine dispersion process

Active Publication Date: 2010-02-24
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the difficulty in selecting materials with good clathrate stability for iodine, and the immature dispersion process of iodine, there are few literature reports on the preparation and application of nano-scale iodine and its derivatives.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Dissolve 1 part of iodine and potassium iodide with a mass ratio of 0.8:1 to its total mass ratio of 12:1 in 1,4-dioxane, and disperse iodine under high-speed emulsification and stirring at 800 rpm. The pH of the solution system was adjusted to 4.5 by 5% dilute acetic acid solution. Add sodium dodecylsulfonate with a mass ratio of 0.6:1 to iodine, emulsify and stir in a high-speed emulsifying mixer at a speed of 800 rpm for 60 minutes to uniformly disperse the surfactant and iodine. Chitosan grafted poly(vinylpyrrolidone-co-methyl acrylate) (the molar ratio of the two comonomers is 9:1) was weighed according to the mass ratio of iodine to 3:1, dissolved in the amphiphilic After forming a homogeneous solution in distilled water with a mass ratio of 5:1 of the graft copolymer, add iodine / sodium dodecylsulfonate surfactant composite solution, emulsify and stir at a speed of 800 rev / min for 60 Minutes make the iodine / surfactant complex fully complex with chitosan grafted p...

Embodiment 2

[0056] Dissolve 1 part of iodine and potassium iodide with a mass ratio of 2.5:1 to its total mass ratio of 8:1 in tert-butanol, and disperse the iodine under high-speed emulsification stirring at 600 rpm, and pass through 5% dilute The acetic acid solution adjusts the pH of the solution system to 4.5. Add cetyltrimethylammonium chloride with a mass ratio of 0.8:1 to iodine, emulsify and stir in a high-speed emulsifying mixer at a speed of 600 rpm for 120 minutes to uniformly disperse the long-chain alkyl surfactant and iodine. Carboxymethyl chitosan grafted poly(vinylpyrrolidone-co-vinyl acetate) (the molar ratio of the two comonomers is 8:2) was weighed according to the mass ratio of iodine to 5:1, and dissolved in After forming a uniform solution in distilled water with an amphiphilic graft copolymer mass ratio of 5:1, add iodine / hexadecyltrimethylammonium chloride surfactant composite solution, and in a high-speed emulsifying mixer at 600 rpm Emulsify and stir at a high s...

Embodiment 3

[0058] Dissolve 1 part of iodine and potassium iodide with a mass ratio of 0.9:1 to its total mass ratio of 10:1 in DMSO, disperse iodine under high-speed emulsification stirring at 600 rpm, and pass through 5% dilute acetic acid solution Adjust the pH of the solution system to 5.5. Add the lauryl alcohol polyoxyethylene ether surfactant with the iodine mass ratio of 0.4:1, and emulsify and stir at a speed of 600 rpm in a high-speed emulsifying mixer for 60 minutes to make the lauryl alcohol polyoxyethylene ether surfactant Disperse evenly with iodine. Chitosan grafted poly(vinylpyrrolidone-co-sodium acrylate-co-methyl acrylate) (the molar ratio of the three comonomers is 3:6:1) was weighed according to the mass ratio of iodine to 6:1 After being dissolved in distilled water with a mass ratio of 5:1 to the amphiphilic graft copolymer to form a homogeneous solution, add iodine / dodecanol polyoxyethylene ether surfactant composite solution, in a high-speed emulsifying mixer at 6...

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Abstract

The invention provides a composite of natural macromolecule or amphiphilic grafting copolymer of water-soluble derivant and nanometer iodine and preparation method thereof, wherein the preparation method comprises steps as follows: agitating-emulsifying the iodine, iodized salt and surfactant at high speed under a condition that the PH is 3.0-6.8 to form a composite solution, adding the natural macromolecule or the amphiphilic grafting copolymer of water-soluble derivant for further agitating-emulsifying and dispersing at high speed; and finally obtaining the composite of the natural macromolecule or amphiphilic grafting copolymer of water-soluble derivant with nanometer iodine. In comparison with the existing macromolecule-iodine composite, the composite is better in antibacterial effectand longer in function persistence, is capable of being used as antibacterial solution or recomposed into gelatine for usage as well as heated in vacuum and dried in freeze condition for usage after concentrated, or recomposed into corresponding preparation together with other secondary material after concentrated.

Description

technical field [0001] The invention relates to a compound of novel amphiphilic graft copolymer of natural macromolecule or its water-soluble derivative and iodine, and a preparation method thereof. Background technique [0002] Iodine has broad-spectrum antibacterial effect and strong antibacterial activity. However, because iodine is easy to sublimate, iodine is usually compounded with various substrates to improve its stability and facilitate further use. Traditional iodine compounds such as povidone iodine, iodophor, tincture of iodine, and Aner iodine, etc. Although these compounds have been used more commonly, it is still found that these compounds have a small amount of complexing to iodine during use, the dispersion uniformity is difficult to ensure, the stability is not good, and the iodine is easily lost. The skin is particularly irritating to the damaged wound, and the products have defects such as short shelf life. The applicant mentioned a new chitosan derivat...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F251/02C08F289/00C08F253/00C08F8/18A61K31/79A61P31/00A61P31/12A01N59/12A01P1/00
Inventor 陈煜
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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