Production method of feed colistin sulfate microcapsules

A colistin sulfate and production method technology, applied in animal feed, animal feed, application, etc., can solve the problems of colistin sulfate potency decrease, bioavailability decrease, etc., to prolong drug action time and improve bioavailability Degree, the effect of reducing the cost of medication

Inactive Publication Date: 2010-03-10
WUXI ZHENGDA POULTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, colistin sulfate is strongly acidic, and there are many alkaline substances in the feed, such as vitamins, trace elements, etc., which are easy to react with colistin sulfate, which will reduce the potency and bioavailability of colistin sulfate.

Method used

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  • Production method of feed colistin sulfate microcapsules
  • Production method of feed colistin sulfate microcapsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Take colistin sulfate, HPMC and magnesium stearate, pass through a 60-mesh sieve respectively, mix evenly with 15kg of colistin sulfate, 10kgHPMC, and 8kg of magnesium stearate, add 67kg of water and mix evenly, and make colistin sulfate and capsule Material mixed solution, the mixed solution of colistin sulfate and capsule material is sprayed and dried in spray equipment, and colistin sulfate microcapsules are obtained. Then add 35 kg of the microcapsules to 5 kg of 60 mesh magnesium stearate and 60 kg of starch for mixing to obtain the final product. The spray drying process conditions are as follows: liquid supply rate: 10ml·min-1; inlet air temperature: 105°C; outlet air temperature: 70°C, atomized gas flow rate: 300L·h-1, moisture after drying: 6%.

Embodiment 2

[0014] Add 10kg HPMC and 9kg magnesium stearate to 16kg colistin sulfate, pass through a 60-mesh sieve and mix evenly, add 65% water and mix evenly to make a mixed solution of colistin sulfate and capsule material, mix colistin sulfate and capsule material The solution is spray-dried in spray equipment to obtain colistin sulfate microcapsules. Then add 35 kg of the microcapsules to 5 kg of 60 mesh magnesium stearate and 60 kg of starch for mixing to obtain the final product. The spray drying process conditions are as follows: liquid supply rate: 10ml·min-1; inlet air temperature: 105°C; outlet air temperature: 70°C, atomized gas flow rate: 300L·h-1, moisture after drying: 6%.

Embodiment 3

[0016] Use 18kg of colistin sulfate plus 11kg of HPMC and 8kg of magnesium stearate, pass through a 60 mesh sieve and mix evenly, add water 63 and mix evenly to make a mixed solution of colistin sulfate and capsule material, and mix solution of colistin sulfate and capsule material Spray equipment is set for spray drying to obtain colistin sulfate microcapsules. Then add 35 kg of the microcapsules to 5 kg of 60 mesh magnesium stearate and 60 kg of starch for mixing to obtain the final product. The spray drying process conditions are as follows: liquid supply rate: 10ml·min-1; inlet air temperature: 105°C; outlet air temperature: 70°C, atomized gas flow rate: 300L·h-1, moisture after drying: 6%.

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Abstract

The invention relates to a production method of feed colistin sulfate microcapsules, which comprises the following processing steps: 1. preparing a mixed solution of colistin sulfate and capsule material; 2. carrying out spray drying; and 3. adding a proper amount of antitackiness agent and auxiliary material and mixing. The production method has the advantages that the colistin sulfate is wrappedby polymer substances, so that the colistin sulfate is isolated from the external environment, not only protecting the effective valence of colistin, but also protecting vitamins and alkaline trace elements in feed from reacting with strongly acidic colistin through the isolation of a polymer film when the colistin and the feed are mixed. The polymer film is gradually dissolved after entering intestinal tracts, and colistin molecules are also released step by step to exert drug efficacy, improving the bioavailability of the colistin sulfate, prolonging the acting time of drugs, reducing the administration times, lowering the administration cost of raisers, and improving the economic benefit.

Description

technical field [0001] The invention relates to a production method of colistin sulfate microcapsules for feed. The invention belongs to the technical field of feed and feed additives. Background technique: [0002] Colistin Sulfate, also known as Colistin Sulfate, Colistin, Polymyxin E (Polymyxin E), Antiadrin, etc., is a white or near-white powder, odorless, bitter and hygroscopic, and easily soluble Soluble in water, slightly soluble in methanol, ethanol, soluble in acetone, ether, etc., the aqueous solution is strongly acidic. Colistin sulfate is produced by Polymyxa bacterium and has strong antibacterial effect on Gram-negative bacteria. It is used to prevent and treat intestinal diseases caused by Gram-negative bacteria. It is used as a feed additive and has obvious growth-promoting effect . However, colistin sulfate is strongly acidic, and there are many alkaline substances in the feed, such as vitamins and trace elements, which are easy to react with colistin sulf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/17A23K20/195
Inventor 周玲叶锋先
Owner WUXI ZHENGDA POULTRY
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