Method for preparing hydroxy propyl-beta-schardinger dextrin-radix puerariae-isoflavone inclusion compound slow-release capsules

A technology of kudzu root isoflavones and sustained-release capsules, which is applied in the field of bioengineering, can solve problems that have not been reported, and achieve the effects of increasing the dissolution rate, increasing the relative bioavailability of the human body, and improving the timeliness

Inactive Publication Date: 2010-03-10
JIANSU MAOBAO GEYE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But about utilizing hydroxypropyl-beta-cyclodextrin to clathrate kudzu root isoflavones, then utilizing skeleton material-ethyl cellulose, porogen-hydroxypropyl methyl cellulose as slow-release excipients, solid dispersion technology to prepare HP- There is no report on the patent on β-CD kudzu root isoflavone inclusion complex sustained-release capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] Step 1: In a stainless steel ceramic reaction kettle, under the conditions of a jacketed water bath temperature of 60°C and a stirrer speed of 130 rpm, 10kg of hydroxypropyl-β-cyclodextrin was made into a saturated aqueous solution, and then gradually added 3.45kg of hot water solution of kudzu root isoflavone extract (total flavonoid content is 60.2%), stirred and mixed for 2.0h, allowed to stand at room temperature for 12h, filtered, the filtrate was concentrated to 1 / 3 volume, vacuum dried under reduced pressure at 60°C, solid Pulverize to obtain HP-β-CD kudzu root isoflavone inclusion compound.

[0019] Step 2: A certain proportion of auxiliary materials: 3.5kg of ethylcellulose (EC), 0.3kg of hydroxypropylmethylcellulose (HPML) and 3.1kg of clathrates prepared in step 1 are placed in a dry container , add an appropriate amount of 95% ethanol, heat with circulating water at 60°C to make it completely miscible, stir until solid, dry at about 80°C, pulverize, pass thr...

example 2

[0022] Step 1: In a stainless steel ceramic reaction kettle, under the conditions of a jacketed water bath temperature of 70°C and a stirrer speed of 180 rpm, 8 kg of hydroxypropyl-β-cyclodextrin was made into a saturated aqueous solution, and then gradually added with 4.2 Kg of kudzu root isoflavone extract (total flavonoid content is 60.2%) in hot water solution, stirred and mixed for 3.0h, allowed to stand at room temperature for 12h, filtered, the filtrate was concentrated to 1 / 3 volume, vacuum dried under reduced pressure at 60°C, and the solid was pulverized Obtain HP-β-CD kudzu root isoflavone inclusion compound.

[0023] Step 2: A certain proportion of auxiliary materials: 5.0kg of ethylcellulose (EC), 0.23kg of hydroxypropylmethylcellulose (HPML) and 2.3g of clathrates prepared in step 1 are placed in a dry container , add an appropriate amount of 95% ethanol, heat with circulating water at 60°C to make it completely miscible, stir until solid, dry at about 80°C, pulv...

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PUM

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Abstract

The invention discloses a method for preparing a hydroxy propyl-beta-schardinger dextrin-radix puerariae-isoflavone inclusion compound slow-release capsules. The method comprises the following steps:preparing an inclusion compound: preparing 8-12 parts by weight of hydroxy propyl-beta-schardinger dextrin into a saturated water solution, then adding 2.7-4.2 parts by weight of hot water solution ofa radix puerariae-isoflavone extract step by step, drying by depressurization in vacuum, pulverizing a solid to obtain the inclusion compound; preparing slow-release granules: putting 20-50 parts byweight of ethyl cellulose, 0.87-2.3 parts by weight of hydroxy propyl methyl cellulose and 8-23 parts by weight of obtained inclusion compound into a dry container, mixing, adding an ethanol solution,stirring to solid state, drying, pulverizing to obtain granules; and encapsulating the slow-release capsules: encapsulating the prepared granules into hollow capsules to obtain the hydroxy propyl-beta-schardinger dextrin-radix puerariae-isoflavone inclusion compound slow-release capsules. The invention increases the solubility of radix puerariae and isoflavone in water, enhances the relative bioavailability of the radix puerariae and the isoflavone to a human body and improves the acting time effect of health care.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and relates to a health food, in particular to a method for preparing sustained-release capsules by inclusion of kudzu root isoflavones with beta-cyclodextrin derivatives. Background technique [0002] Pueraria lobata Ohwi is the root of the leguminous plant Pueraria lobata Ohwi. It is a commonly used traditional Chinese medicine and is a natural plant with the same source of medicine and food. Its medicinal value is first recorded in "Shen Nong's Materia Medica": it is sweet and pungent, and has various effects such as increasing blood flow in the brain and coronary arteries, reducing blood pressure vascular resistance, contracting smooth muscle, lowering blood sugar, and antipyretic. Modern research shows that the medicinal value of Pueraria root depends on the main active substance - Puerarin isoflavones, including: Puerarin, daidzin, daidzein and puerarin. Pueraria isoflavones are fla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K9/52A61K47/48A61K47/38A61P35/00A61P9/00A61P39/06A61P19/10A23L1/29A61K125/00
Inventor 夏荣光张东升王红连赵晓联李书娟秦海萍张凌裳
Owner JIANSU MAOBAO GEYE CO LTD
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