Divalproex sodium medicine composition with improved oral absorptivity

The technology of sodium divalproex and composition is applied in the field of sodium divalproex pharmaceutical composition and preparation thereof, which can solve the problems of poor particle fluidity, low release degree, stickiness and the like, and achieves improved bioavailability The effect of improving the release degree in vitro and simple operation
CN101693113AInactive Publication Date: 2010-04-14TIANJIN HANKANG PHARMA BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN HANKANG PHARMA BIOTECH
Publication Date
2010-04-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a medicine composition containing divalproex sodium, which can be applied to patients safely, not only can improve the wettability and the flowability of the divalproex sodium, but also can improve the absorptivity of the divalproex sodium in gastrointestinal tracts. Particularly, the invention relates to a medicine composition containing amorphous divalproex sodium and betacyclodextrin. The preparation method of the medicine composition comprises the following steps: grinding, drying and pulverizing the divalproex sodium and the betacyclodextrin to obtain fine powder of 80-100 meshes; mixing with proper assistant materials and making into granules, and then tabletting and coating to obtain the medicine composition. The divalproex sodium medicine composition not only can improve release in vitro to a greater degree, thereby improving bioavailability, but can effectively treat epilepsia and vesania and prevent cephalagra; in addition, the divalproex sodium medicine composition can be taken orally and conveniently, can cover odor, and can be disintegrated and absorbed quickly and carried conveniently.
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Description

technical field

[0001] The invention relates to a medicinal composition of divalproex sodium and a preparation method thereof. Dispersing divalproex sodium in beta-cyclodextrin can greatly increase the release rate in vitro, thereby improving the bioavailability. Background technique

[0002] Epilepsy is one of the oldest human diseases. The World Health Organization (WHO) definition of epilepsy: Epilepsy is a chronic disease with recurrent seizures, protracted disease course, and sudden brain dysfunction. It is characterized by sudden abnormal high-frequency discharge of brain neurons and spreading to the surroundings. Due to the different locations of abnormal discharge neurons, the clinical manifestations are different symptoms of motor, sensory, consciousness and autonomic dysfunction. The types of seizures are also divided into partial seizures, generalized seizures, and generalized tonic-clonic seizures. The seizure classification of a small number of patients is not...

Claims

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