Artificial blood vessel for catalyzing endogenous NO precursor to release NO and preparation method

A technology of artificial blood vessels and precursors, applied in the field of biomedical applications of polymer materials, can solve the problems of cumbersome preparation, poor controllability, and inability to control the release of NO for a long time, so as to facilitate diffusion, simple processing, and inhibit platelets Aggregated effect

Active Publication Date: 2010-05-12
南通双辉医疗器械科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of the existing NO release blood contact materials is cumbersome and difficult, and the blood contact materials still only have a fixed NO storage capacity, so the continuous long-term release of NO is limited, and the NO release cannot be controlled for a long time, and the controllability is poor.

Method used

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  • Artificial blood vessel for catalyzing endogenous NO precursor to release NO and preparation method

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Experimental program
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Effect test

Embodiment 1

[0037] The artificial blood vessel that catalyzes the release of endogenous NO precursors is composed of a three-dimensional network non-woven membrane tube structure formed by inner and outer layers of nanofibers, and is made by the following method:

[0038] (1) Dissolve gelatin, ascorbic acid, and sodium nitrite in water at a mass ratio of 100:0.05:0.001 to make a 20% spinning stock solution with a mass fraction of gelatin, and put it into an electrospinning device. In the electrospinning method, the fibers ejected and formed from the spinning nozzle in the electrospinning equipment are collected on the collection roller to form a nanofiber non-woven membrane tube;

[0039](2) dissolving polyurethane CorethaneTM and copper salt chelate in a mass ratio of 100: 0.05 in a mixed solvent of tetrahydrofuran and N, N-methylformamide in a mass ratio of 100: 100 to make polyurethane mass fraction It is a 15% polyurethane spinning stock solution, which is loaded into the electrospinn...

Embodiment 2

[0042] The artificial blood vessel that catalyzes the release of endogenous NO precursors is composed of a three-dimensional network non-woven membrane tube structure formed by inner and outer layers of nanofibers, and is made by the following method:

[0043] (1) Dissolve gelatin, ascorbic acid, and sodium nitrite in water at a mass ratio of 100:0.05:0.01 to make a 20% spinning dope with a mass fraction of gelatin, and put it into an electrospinning device. In the electrospinning method, the fibers ejected and formed from the spinning nozzle in the electrospinning equipment are collected on the collection roller to form a nanofiber non-woven membrane tube;

[0044] (2) Polyurethane CorethaneTM and copper salt chelate are dissolved in a mass ratio of 100: 0.1 in a mixed solvent of tetrahydrofuran and N, N-dimethylformamide in a mass ratio of 100: 0.1 to make polyurethane mass The polyurethane spinning stock solution with a fraction of 15% is put into the electrospinning equipm...

Embodiment 3

[0047] The artificial blood vessel that catalyzes the release of endogenous NO precursors is composed of a three-dimensional network non-woven membrane tube structure formed by inner and outer layers of nanofibers, and is made by the following method:

[0048] (1) Dissolve gelatin, ascorbic acid and sodium nitrite in water at a mass ratio of 100:0.05:0.02 to make a spinning stock solution with a mass fraction of gelatin of 20%, and put it into an electrospinning device. In the electrospinning method, the fibers ejected and formed from the spinning nozzle in the electrospinning equipment are collected on the collection roller to form a nanofiber non-woven membrane tube;

[0049] (2) Polyurethane CorethaneTM and copper salt chelate are dissolved in a mass ratio of 100: 0.2 in a mixed solvent of tetrahydrofuran and N, N-dimethylformamide in a mass ratio of 100: 0.2 to make polyurethane mass The polyurethane spinning stock solution with a fraction of 15% is put into the electrospi...

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Abstract

The invention discloses an artificial blood vessel for catalyzing an endogenous NO precursor to release NO and a preparation method. The artificial blood vessel consists of a three-dimensional reticular non-woven film pipe structure formed by an inner layer of nano fibers and an outer layer of nano fibers. The artificial blood vessel is prepared by the method comprising the following steps of: dissolving gelatin, ascorbic acid and sodium nitrite in water to obtain a spinning dope so as to prepare nano fiber non-woven film pipes; dissolving polyurethane and nantokite chelate in a mixed solvent of tetrahydrofuran and N,N-dimethyl fomamide to prepare a polyurethane spinning dope; continuing collecting fibers on a collecting roller with nano fiber non-woven film pipes so as to form polyurethane non-woven film pipes; soaking and treating the polyurethane non-woven film pipes in an aqueous solution of a crosslinking agent; and cleaning and drying to prepare the artificial blood vessel for catalyzing endogenous NO precursor to release NO. The artificial blood vessel can catalyze to release NO for a long time. The method is simple, and the degree of crosslinking is easy to control.

Description

technical field [0001] The invention belongs to the biomedical application field of polymer materials, and relates to an artificial blood vessel capable of catalyzing and releasing nitric oxide and a preparation method thereof. Background technique [0002] Severe damage to human blood vessels has become a difficult problem in the medical field due to poor self-repair ability. Since the clinical success of artificial blood vessels made of vinylon in 1952, people have successively developed artificial blood vessels made of various materials. The commonly used transplanted blood vessels are mainly made of materials such as polyester, nylon and polytetrafluoroethylene, but these materials do not support the adhesion and growth of human endothelial cells, making it difficult to fully endothelialize the blood vessels implanted in the human body, and have a negative effect on the blood vessels. Long-term adaptation creates barriers. Therefore, this type of blood vessel can only b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/22A61L27/18D01D1/02D01D5/00
Inventor 冯亚凯郭锦棠肖若芳
Owner 南通双辉医疗器械科技有限公司
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