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Enteric plant hollow capsule

A technology for plant hollow capsules and capsules is applied in the directions of capsule delivery, medical preparations of inactive ingredients, pharmaceutical formulations, etc., to achieve the effects of improving efficiency, simplifying the process, and eliminating the coating process.

Active Publication Date: 2010-05-19
ANHUI HUANGSHAN CAPSULE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this kind of capsule can only dissolve in the stomach of the human body.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1, get 30kg of low-ester pectin, 3kg of carrageenan or gellan gum, 3kg of potassium citrate, polyvinyl alcohol, sorbitol, glycerin, polyethylene glycol, inositol, maltitol or one or more mixed 6kg , Purified water 60kg.

[0021] The production equipment is the same as the existing production of hollow capsules with gelatin. Pour the low-ester pectin and water into the reaction pot, heat, stir and dissolve, then add curing agent, coagulant and plasticizer, the circulating water temperature of the reaction pot is 60°C-90°C, stir for 2-4 hours, after fully dissolving Use a 150-mesh filter bag to filter the glue solution, store the glue solution in the heat preservation barrel, adjust the concentration of the glue solution according to the specific gravity, add food coloring of various colors according to the needs of users, and add a certain amount of sunscreen agent titanium dioxide, etc., statically Put it in heat preservation and then remove air bubbles, the...

Embodiment 2

[0022] Embodiment 2, get 30kg of high-ester pectin, 2kg of carrageenan or xanthan gum, 2kg of potassium citrate, polyvinyl alcohol, sorbitol, glycerin, polyethylene glycol, inositol, maltitol or one or more mixed 4kg , Purified water 60kg. Its production method is with embodiment 1.

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PUM

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Abstract

The invention relates to an enteric plant hollow capsule which is prepared by a method comprising: firstly adding 60-85% of pectin, 5-20% of plasticizer, 5-10% of coagulant aid and 5-10% of water used for curing agent into a reaction pot; stirring and dissolving at 60-90 DEG C, and obtaining glue stock by filtering and adjusting specific gravity; removing air bubbles and then sending into a capsule production line for the treatment such as dipping in glue, drying, cooling, demoulding, cutting, sheathing, etc. The enteric plant hollow capsule has the disintegration time limit of 3-4h in gastric juice and 30-45min in intestinal juice. Compared with the existing enteric capsule, the enteric plant hollow capsule omits the working procedure of coating, simplifies the technique, and completely uses no organic solvent, thus not only being beneficial to safe production and environmental protection, but also being beneficial to improving the efficiency and reducing the cost.

Description

1. Technical field [0001] The invention relates to an enteric-coated empty capsule as a medicinal auxiliary material, in particular to a targeted and plant-based enteric-coated empty capsule that does not allow disintegration in the stomach of a human body but dissolves rapidly in the small intestine of a human body. 2. Technical Background [0002] Enteric-coated hollow capsule (capsule shell) means that the shell is insoluble in gastric juice, but can disintegrate or dissolve in intestinal juice to release the drug in the capsule. The shell is also the main auxiliary material for processing pharmaceutical capsule preparations. Currently used enteric-coated empty capsules are processed and shaped by gelatin and coated with an anti-gastric acid enteric coating material. The gelatin is firstly soaked in purified water, swollen, and then gelatinized, and then sent to the capsule production line to be dipped in glue, dried and solidified to obtain gelatin hollow capsule materia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36
Inventor 刘松林
Owner ANHUI HUANGSHAN CAPSULE CO LTD
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