Preparation method of silybum marianum total flavonoid as active ingredient of swertia pseudochinensis-silybum marianum liver benefiting product

An active ingredient, the technology of milk thistle, which is applied in the field of preparation of total flavonoids of milk thistle, can solve the problems of low yield of total flavonoids of active ingredients milk thistle, insufficient contact between medicinal materials and solvents, and influence on the leaching of active ingredients. Achieve the effects of improving the leaching effect, increasing the content, and increasing the content of effective substances

Inactive Publication Date: 2010-06-09
SICHUAN MEDCO PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantage is that the process is rough, and the yield of total flavonoids of effective components milk thistle is low
[0003] In the general percolation method, the medicinal material is directly infiltrated after crushing. Due to the influence of factors such as the gap between the medicinal material particles, the medicinal material and the solvent cannot be fully contacted, which affects the leaching of active ingredients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Squeeze oil from milk thistle seeds and collect milk thistle dregs.

[0022] 2. Crush the milk thistle dregs through a 20-mesh sieve, put them into the percolation tank, seal it, draw a vacuum, control the vacuum degree at -0.02~-0.1Mpa, keep the vacuum state for about 25 minutes, and then add about 1.2 80% ethanol, which is twice the weight of medicinal materials, is soaked for 48 hours; maintain a pressure of 0.05-0.15 MPa in the tank, and carry out percolation, and the flow rate of percolation liquid is maintained at 98L-100L per hour; at the same time, continuously add 80% ethanol at this speed, During the process, keep the ethanol liquid level not lower than the drug level, and collect percolation liquid 8 times the weight of the medicinal material.

[0023] 3. Recover ethanol from the percolation liquid, concentrate it to a thick paste with a specific gravity of 1.20-1.25 (60°C), dry it under reduced pressure at 62-68°C, and obtain a dry paste of milk thistle t...

Embodiment 2

[0027] 1. Squeeze oil from milk thistle seeds and collect milk thistle residue;

[0028] 2. Crush the milk thistle dregs through a 20-mesh sieve, put them into the percolation tank, seal it, draw a vacuum, control the vacuum degree at -0.02~-0.1Mpa, keep the vacuum state for about 16 minutes, and then add 1 ~1.5 times the weight of medicinal materials in 80% ethanol, soak for 48 hours; keep the pressure of 0.05~0.15MPa in the tank, carry out percolation, and keep the flow rate of percolation liquid at about 100L per hour; Keep the ethanol liquid level not lower than the drug level during the rinsing process, and collect percolation liquid 8.5 times the weight of the medicinal material.

[0029] 3. Recover ethanol from the percolation liquid, concentrate it to a thick paste with a specific gravity of 1.20-1.25 (60°C), dry it under reduced pressure at 60-70°C, and obtain dry paste of milk thistle total flavonoids;

[0030] 4. Grinding the dry paste through an 80-mesh sieve to o...

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PUM

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Abstract

The invention discloses a preparation method of silybum marianum total flavonoid as an active ingredient of a swertia pseudochinensis-silybum marianum liver benefiting product. In the method, ordinary percolation used by silybum marianum in an original national pharmaceutical standard is changed into vacuum pressure percolation, namely the method comprises the following steps of: vacuumizing squeezed oil-free silybum marianum powder, then adding 80 percent ethanol in a vacuum state and dipping; then pressurizing and percolating; recovering the ethanol of percolating liquid; and concentrating and drying to obtain the silybum marianum total flavonoid. The pressurizing and percolating method improves the speed of a solvent for immerging plant tissue cells so as to ensure that active ingredients are quickly leached to improve the leaching quantity of the active ingredients, and the percolating process is smoothly carried out. The method ensures that the content of the active ingredient, namely the silybum marianum total flavonoid, in the swertia pseudochinensis-silybum marianum liver benefiting product is obviously improved so as to be beneficial to improving the quality of the swertia pseudochinensis-silybum marianum liver benefiting product and enhancing the clinical treatment effect of the medicament.

Description

technical field [0001] The invention relates to Dangfei Liganning medicine, in particular to a preparation method of total flavonoids of milk thistle, an active ingredient in the medicine preparation. Background technique [0002] Dangfei Ligan Ning is a standard traditional Chinese medicine preparation issued by the Ministry of the People's Republic of China. It is a pure natural medicine prepared from the traditional folk medicine for treating hepatitis and the plant milk thistle introduced from West Germany in the 1970s. The drug can protect the normal structure and function of liver cells, reduce the damage of various poisons to liver cells, inhibit the formation of inflammatory mediator tumor necrosis factor, reduce alanine aminotransferase, promote bile excretion, and has the effects of clearing dampness and heat, benefiting the liver and reducing jaundice . The drug is used for jaundice caused by damp-heat stagnant steaming, acute icteric hepatitis, and chronic hepat...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P1/16A61P3/06
Inventor 卿光明余定祥钟瑛
Owner SICHUAN MEDCO PHARML
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