Method for preparing film coating tablet for treating chronic renal failure

A film-coated tablet and kidney function technology, applied in the field of film-coated tablet preparation, can solve the problems of no dosage form, patients should not drink more water, research and development, etc., achieve the effects of less water consumption, prolonging the validity period of drugs, and reducing production costs

Inactive Publication Date: 2010-06-09
东方药林药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem that patients with chronic renal failure should not drink more water, and considering the convenience of taking, carrying and transporting the drug and the stability of the drug, the market needs oth

Method used

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  • Method for preparing film coating tablet for treating chronic renal failure
  • Method for preparing film coating tablet for treating chronic renal failure
  • Method for preparing film coating tablet for treating chronic renal failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation method of the film-coated tablet for the treatment of chronic renal failure comprises the steps of:

[0017] Get medicinal extract powder 350g, cross 100 mesh sieves, add microcrystalline cellulose 150g, mix well, add 150ml 80% ethanol soft material, granulate (24 mesh sieves), dry 40 minutes (70 ℃), granulate, Add 5g of magnesium stearate and mix evenly, press into 1000 tablets, take another 15g of thin film coating powder, mix it with water to make a 15% coating solution, control the tablet bed temperature at 45-48°C, and the spraying speed of the coating solution is 4-5ml / min, film-coated, that is.

Embodiment 2

[0019] The preparation method of the film-coated tablet for the treatment of chronic renal failure comprises the steps of:

[0020] Get medicinal extract powder 320g, cross 100 mesh sieves, add microcrystalline cellulose 180g, mix well, add 150ml 80% ethanol soft material, granulate (24 mesh sieves), dry 40 minutes (70 ℃), granulate, Add 6g of magnesium stearate and mix evenly, press into 1000 tablets, take another 14g of film coating material, and make an 18% solution with water, control the tablet bed temperature at 45-48°C, and spray the coating liquid at a rate of 4-5ml / min, coated with film, that is.

Embodiment 3

[0022] The preparation method of the film-coated tablet for the treatment of chronic renal failure comprises the steps of:

[0023] Get medicinal extract powder 400g, cross 100 mesh sieves, add microcrystalline cellulose 100g, mix well, add 150ml 70% ethanol soft material, granulate (24 mesh sieves), dry 40 minutes (70 ℃), granulate, Add 7g of magnesium stearate and mix evenly, press into 1000 tablets, take another 13g of film coating material, and make a 12% solution with water, control the tablet bed temperature at 45-48°C, and spray the coating solution at a speed of 4-5ml / min, coated with film, that is.

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Abstract

The invention discloses a method for preparing a film coating tablet for treating chronic renal failure. The method comprises the following steps: proportioning various crude medicines of rhubarb, astragalus root, white mulberry root-bark, kuhseng, radix codonopsis pilosulae, white atractylodes rhizome, tuckahoe, prepared fleece flower root, white peony root, radix salviae miltiorrhizae, rhizoma ligustici wallichii, chrysanthemum, pinellia, plantain, radix bupleuri and licorice according to a conventional method, adding water, decocting, filtering, merging decoction, concentrating, drying and pulverizing to obtain medicinal extract powder; the method is characterized by also comprising the following steps: adding microcrystalline cellulose into the medicinal extract powder, mixing evenly, preparing a soft material by an ethanol water solution, granulating, drying, straightening, adding magnesium stearate, mixing evenly, tabletting to obtain a tablet agent and then coating a film coating by a film coating material; the mass ratio of the medicinal extract powder to the microcrystalline cellulose to the magnesium stearate to the film coating powder is 60-75:20-36:0.5-1.3:2-6; and the conditions of the technical parameters of the coating process for coating the film coating are as follows: the concentration of coating liquid prepared by the film coating material is 10-20wt%, the temperature of a tablet bed is 45-48 DEG C, and the liquid spraying speed of the coating liquid is 4-5ml/min.

Description

technical field [0001] The invention relates to a preparation method of a film-coated tablet for treating chronic renal failure. It belongs to the technical field of traditional Chinese medicine and natural medicine research. Background technique [0002] Kidney disease is a common disease, and about 96 to 100 people per million people develop from kidney disease to renal failure every year. Uremia is the end stage of chronic renal failure (CRF). In addition to water and electrolyte metabolism disorders and acid In addition to the imbalance of alkali balance, the accumulation of a large number of metabolites in the human body causes symptoms of poisoning in the digestive tract, heart, lungs, nerves, skin, muscles, blood and other systemic systems, which is one of the most complicated and difficult problems in clinical nephrology. , which belongs to the category of insufficiency, closure, drug addiction, and consumptive fatigue in traditional Chinese medicine. A large numbe...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61K9/28A61P13/12
Inventor 雷晓林侯连兵刘伟钱星文曲富江
Owner 东方药林药业有限公司
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