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Method for preparing antibacterial nanometer silver colloid

A nano-silver sol, water-soluble technology, applied in botany equipment and methods, chemicals for biological control, biocides, etc., can solve the problems of poor stability of nano-silver, and achieve low cost, short production cycle, and high production efficiency. high rate effect

Active Publication Date: 2012-07-25
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, experimental studies have found that the stability of the prepared nano-silver is poor, and after a period of time, there will be black powdery precipitates in the nano-silver sol.

Method used

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  • Method for preparing antibacterial nanometer silver colloid
  • Method for preparing antibacterial nanometer silver colloid
  • Method for preparing antibacterial nanometer silver colloid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) take by weighing 0.0085g silver nitrate and prepare 50ml concentration with deionized water and be the silver nitrate aqueous solution of 0.001M, then get 0.0085g dextran and be dissolved in above-mentioned silver nitrate aqueous solution (the mass ratio of dextran and silver nitrate is 1: 1), slowly stir for subsequent use;

[0029] (2) Weigh 0.0189g of sodium borohydride and prepare 250ml of sodium borohydride aqueous solution with a concentration of 0.002M with deionized water, and ice-bath for 20min;

[0030] (3) the dextran-containing silver nitrate aqueous solution of step (1) is added dropwise in the sodium borohydride aqueous solution under the ice bath, and the dropping speed is 60 drops / min, while using a magnetic stirrer to stir vigorously, the rotating speed is 500 rpm;

[0031] (4) Continue to stir for 20 minutes after the dropwise addition to make it fully react.

[0032] Finally, a bright yellow nano-silver sol is obtained, the average particle size...

Embodiment 2

[0034] (1) take by weighing 0.085g silver nitrate and prepare 50ml concentration with deionized water and be the silver nitrate aqueous solution of 0.01M, then get 0.085g dextran and be dissolved in above-mentioned silver nitrate aqueous solution (the mass ratio of dextran and silver nitrate is 1: 1), slowly stir for subsequent use;

[0035] (2) Weigh 0.189g of sodium borohydride and prepare 250ml of sodium borohydride aqueous solution with a concentration of 0.02M with deionized water, and ice-bath for 30min;

[0036] (3) the dextran-containing silver nitrate aqueous solution of step (1) is added dropwise in the sodium borohydride aqueous solution under the ice bath, and the dropping speed is 45 drops / min, while using a magnetic stirrer to stir vigorously, the rotating speed is 800 rpm;

[0037](4) Continue to stir for 30 minutes after the dropwise addition to make it fully react.

[0038] Finally made red black nano-silver sol, the average particle diameter of nano-silver ...

Embodiment 3

[0040] (1) take by weighing 0.17g silver nitrate and prepare 100ml concentration with deionized water and be the silver nitrate aqueous solution of 0.01M, then get 0.085g dextran and 0.085gPVP miscible in above-mentioned silver nitrate aqueous solution (dextran / PVP mixed protecting agent The mass ratio with silver nitrate is 1: 1), slowly stirred for subsequent use;

[0041] (2) Weigh 0.378g of sodium borohydride and prepare 500ml of sodium borohydride aqueous solution with a concentration of 0.02M with deionized water, and ice-bath for 30min;

[0042] (3) The silver nitrate aqueous solution containing the dextran / PVP protective agent of step (1) is added dropwise in the sodium borohydride aqueous solution under the ice bath, and the dropping speed is 45 drops / min, while using a magnetic stirrer to vigorously Stirring, the rotating speed is 800 rpm;

[0043] (4) Continue to stir for 30 minutes after the dropwise addition to make it fully react.

[0044] Finally, a red and bl...

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Abstract

The invention discloses a method for preparing antibacterial nanometer silver colloid, belonging to the technical field of nanometer biological materials. The method uses a chemical reduction method, comprising the following steps: dissolving water-soluble protective agent in silver nitrate water solution with the concentration of 0.001-0.1mol / L, wherein the mass ratio of protective agent to silver nitrate is 0.5-10.0:1; carrying out ice bath on sodium borohydride water solution with the concentration of 0.001-0.2mol / L for 10-30min; and dropwise adding the silver nitrate water solution containing protective agent in the sodium borohydride water solution with the speed of 30-60 drop / min, stirring by a magnetic stirrer, stirring for 20-40min after dropwise adding to prepare the nanometer silver colloid with the grain size of 5-80nm, wherein the mol ratio of the sodium borohydride to the silver nitrate is 1.0-30.0:1. The nanometer silver colloid prepared by the invention has the advantages of high concentration, high stability, high dispensability, and obviously-enhanced antibacterial property.

Description

technical field [0001] The invention belongs to the technical field of biological nanomaterials, and in particular relates to a preparation method of antibacterial nano silver sol. Background of the invention [0002] The antibacterial application of silver and silver compounds has a long history, but the antibacterial activity of silver colloids was not discovered until the early 20th century. The discovery of antibiotics once brought the development of this field to a standstill. However, with the increasing resistance of pathogenic microorganisms to antibiotics, people began to pay attention to the biological effects of silver colloids again. The antibacterial effect of nano-silver colloid on some strains can be comparable to that of antibiotics. At present, nano-silver has been successfully applied in experimental research such as wound repair and antibacterial fabrics. In addition, nano-silver is also widely used in the fields of environmental protection, textile and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N59/16A01P1/00B22F9/24
Inventor 王常勇杨桂利
Owner INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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