Coating technology of chlorophyll copper sodium tablet film

A technology of sodium copper chlorophyllin and film coating, which is applied to sugar-coated pills, medical preparations with non-active ingredients, and pill delivery, etc. It can solve the problems of overtime disintegration, strong hygroscopicity, and difficult storage, and achieve short coating time , Improve the dissolution rate, and the effect of not easy to split

Inactive Publication Date: 2010-06-16
杭州前进药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. The syrup coating process is based on sucrose, talcum powder, and gelatin, which are a variety of excipients that have nothing to do with drug treatment, and are added to the surface of the drug tablet core. Therefore, long-term use is not suitable for diabetic patients
[0005] 2. It is prone to splinters, flowers, mildew spots, disinteg

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, sodium copper chlorophyllin sheet product prescription:

[0032] Sodium copper chlorophyllin 20g

[0033] Starch 85g

[0034] Dextrin 40g

[0035] Cane sugar powder 45g

[0036] Magnesium stearate 0.6g

[0037] Film coating coating prescription (1000 plain tablets):

[0038] Gastric-soluble film-coated powder 4.0% by weight of plain tablets;

[0039] Completely dissolve the medicinal film coating powder with an appropriate amount of purified water to make a 15% coating suspension, and keep it warm for storage. Put the plain tablet in a film coating pot at 40°C-50°C, operate according to the operating procedure, set the speed at 8-10rpm, turn on the peristaltic pump when the plain tablet is slightly hot, adjust the position of the spray gun, and the spray speed is 5-10rpm. 8ml / min. Dry layer by layer, and blow cold air for 15-20 minutes after the surface is uniform in color.

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PUM

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Abstract

The invention relates to the coating technology of a chlorophyll copper sodium tablet film, which is characterized in that the coating technique process of a film coat comprises the following steps of: properly and completely dissolving medicinal film coating powder to prepare 15 percent coating mixed suspension liquid to keep the temperature and store; placing a white tablet into a film coating pot at 40-50 DEG C; operating according to an operation program and setting a rotation speed to be 8-10rpm; starting a peristaltic pump when the white tablet is slightly heated; and adjusting the position of an adjusting spraying gun with a spraying speed of 5-8ml/min. The drying is carried out layer by layer, the surface color of the tablet is uniform and the tablet is discharged after blowing the cold air for 15-20 minutes. The tablet appearance quality, the weight difference, the disintegration time limitation and the like accord with quality standard requirement, thereby the coating time and the coating materials are saved.

Description

Technical field: [0001] This technology is used in the coating process of sodium copper chlorophyllin tablets to isolate air, avoid light, prevent moisture, and increase the stability of the drug. Background technique [0002] Sodium copper chlorophyllin tablet is an oral preparation processed from derivatives of chlorophyll (extracted from silkworm excrement). It is clinically used to treat leukopenia caused by various reasons, and can also be used for acute and chronic hepatitis, persistent hepatitis and Treatment of hepatomegaly and cirrhosis caused by hepatitis. At present, there are four pharmaceutical manufacturers in China producing this product, all of which are coated with sugar-coated tablets. [0003] Disadvantages of sugar-coated tablets: [0004] 1. The syrup coating process is based on sucrose, talcum powder, and gelatin, which are a variety of excipients that have nothing to do with drug treatment, and are added to the surface of the drug tablet core. Theref...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K31/409A61K47/36A61P7/00A61P1/16
Inventor 易继材贾天亮楼飞群刘国惠唐岚王文喜
Owner 杭州前进药业有限公司
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