Method for producing calcium gluconate by fermenting Aspergillus niger

Abstract

The invention discloses a method for producing calcium gluconate by fermenting Aspergillus niger, which comprises seed culture and fermentation culture, and is characterized in that: Aspergillus niger TN9518 inclined-plane stains are adopted to ferment liquid glucose, the glucose is converted into gluconic acid which exchanges calcium with a calcium-containing compound to generate calcium gluconate, and the calcium gluconate is orderly subjected to aseptic filtration, concentration and crystallization, separation and drying to form a finished product of the calcium gluconate. Through the method, the damage to partial glucose structures due to 121 DEG C sterilization of the glucose is avoided; byproducts do not exist, and the oxidation is concentrated; inorganic salt in a culture medium is omitted; the purity of the product is improved; film condensation is adopted, so steam for normal condensation is saved and the production process is simplified; the labor capacity is improved; secondary water consumption and wastewater generated in the production process are reduced; and recycle is performed synchronously so the environmental pollution is lightened; therefore, the method has the advantages of low energy consumption and low cost.

Description

technical field [0001] The invention relates to a method for producing calcium gluconate, in particular to a method for producing calcium gluconate by fermenting Aspergillus niger. Background technique [0002] Calcium gluconate is a nutritional drug that can reduce the permeability of capillaries, increase the density, maintain the normal excitability of nerves and muscles, strengthen the contractility of the myocardium, and contribute to the formation of bone. In the food industry, it is an additive for health products, and can also be used for compound feed in the breeding industry. Calcium gluconate can also be used to derive chemical products such as gluconic acid, zinc gluconate, and gluconolactone. At present, there are mainly two kinds of calcium gluconate production methods, and their production processes are as follows: figure 1 and figure 2 As shown, in the first method, due to the low solubility of calcium gluconate, the concentration of glucose in the ferment...

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Problems solved by technology

At present, there are mainly two kinds of calcium gluconate production methods, and their production processes are as follows: figure 1 and figure 2 As shown, in the first method, due to the low solubility of calcium gluconate, the concentration of glucose in the fermented liquid is too dilute, no more than 12%, and a large amount of electricity and steam are needed to treat the fermented product, and the product has many impurities, pigments, and production labor. The strength is high, the intermediate loss is large, and the energy consumption is large. Secondary purification is required, which directly affects the purity and yield of the finished product. The entire process produces a large amount of waste water, the production cycle is long, and the production cost is high; Glucose oxidase and catalase are unstable and have high storage requirements. Glucose oxidase and catalase account for 15% of the production cost. During the extraction process, a large amount of steam is used to heat up the enzyme, which also leads to increased production costs.

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