Preparation method for supercritical anti-solvent of water-soluble nano glycyrrhizic acid powder

Abstract

The invention relates to a preparation method for the supercritical anti-solvent of water-soluble nano glycyrrhizic acid powder, and is characterized in that: a CO2 high-pressure pump is started up to inject CO2 into a high-pressure crystallizing kettle by flow rate of 5-20L / h, the temperature of the high-pressure crystallizing kettle is kept at 32-75 DEG C and the pressure is kept at 7.5-25MPa to reach a supercritical state; absolute ethyl alcohol with glycyrrhizic acid content of 1-5mg / ml is sprayed into the high-pressure crystallizing kettle through a spray nozzle with aperture of 20-1000um by flow rate of 1-30ml / min, glycyrrhizic acid powder with average diameter no more than 300nm is precipitated, and CO2 is continuously supplied into the high-pressure crystallizing kettle for at least half an hour to dry the formed nano glycyrrhizic acid powder; and the solvent, i.e. the absolute ethyl alcohol, is separated from CO2 in a separation kettle with pressure of 5-6.5MPa and temperature of 25-50 DEG C, the absolute ethyl alcohol is reused after the absolute ethyl alcohol is recovered, and CO2 gas is directly recycled. The invention has the advantages that the surface of the obtained nano glycyrrhizic acid powder is smooth, the size distribution is even, the water solubility is good, no residual solvent exists, the production technology causes no pollution, the cost is low, the yield is high and the industrialization is easy.

Description

technical field [0001] The invention relates to a method for preparing drug nano-powder, in particular to a method for preparing a supercritical anti-solvent preparation method of glycyrrhizic acid nano-powder for treating hepatitis. technical background [0002] Glycyrrhizic acid, also known as glycyrrhizin, is extracted from the natural plant licorice and is the main active ingredient of licorice. Modern studies have proved that glycyrrhizic acid is widely used in clinical treatment of various acute and chronic hepatitis, bronchitis and AIDS because it has glucocorticoid-like pharmacological effects without serious adverse reactions. It also has the functions of anti-cancer and anti-cancer, interferon-inducing agent and cellular immune regulator. Glycyrrhizic acid can be combined with a variety of alkaloids, antibiotics, amino acids and other compound preparations to have the effects of synergy, solubilization, increasing drug stability, and reducing toxic and side effect...

AI Technical Summary

Problems solved by technology

[0005] Conventional drug nanopowder preparation methods are generally ball milling and jet milling. Although the particle size of the drug can be achieved, it has the disadvantages of high energy consumption, low efficiency, wide particle distribution, easy pollution, unsafe, easy to degrade and destroy the structure of the drug, etc. difficult to drug

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