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Functionalized artificial joint with selenium-loaded nanotube array surface and preparation method thereof

A technology of nanotube arrays and artificial joints, applied in chemical instruments and methods, inorganic chemistry, titanium compounds, etc., can solve problems that do not involve the preparation of the surface of metal substrates, so as to improve the body's immunity, facilitate loading, and have high specific surface area Effect

Inactive Publication Date: 2010-07-07
江苏广达医材集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this preparation method can only focus on the preparation of dispersed titanate structures, and does not involve the preparation of the surface of the metal substrate

Method used

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  • Functionalized artificial joint with selenium-loaded nanotube array surface and preparation method thereof
  • Functionalized artificial joint with selenium-loaded nanotube array surface and preparation method thereof
  • Functionalized artificial joint with selenium-loaded nanotube array surface and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) First choose pure titanium to process the artificial joint;

[0029] (2) Artificial joint surface pretreatment: After the surface is polished, wash it with acetone, deionized water and absolute ethanol in sequence for 10-30 minutes, and then wash it with HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 20-40 seconds, rinse thoroughly with deionized water, and dry for use;

[0030] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 2vol% (volume percent), phosphoric acid 4vol% (volume percent), ammonium fluoride 0.3wt% (mass percent);

[0031] (4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial joint is used as the anode, graphite or platinum sheet is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodization parameters are: voltage 60V, the reactio...

Embodiment 2

[0036] (1) First choose titanium to process the artificial joint;

[0037] (2) Artificial joint surface pretreatment: After the surface is polished, wash it with acetone, deionized water and absolute ethanol in sequence for 30-60 minutes, and then wash it with HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 40-60 seconds, then rinse thoroughly with deionized water, and blow dry with a hair dryer for use;

[0038] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 2vol% (volume percent), phosphoric acid 4vol% (volume percent), ammonium fluoride 0.5wt% (mass percent);

[0039] (4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial joint is used as the anode, graphite is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodization parameters are: voltage 80V, reactio...

Embodiment 3

[0044] (1) First choose pure titanium to process the artificial joint;

[0045] (2) Artificial joint surface pretreatment: after surface polishing, wash with acetone, deionized water and absolute ethanol in sequence for 60-90 minutes, and then wash with HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 60-80 seconds, then rinse thoroughly with deionized water, and blow dry with a hair dryer for use;

[0046] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 4vol% (volume percent), phosphoric acid 6vol% (volume percent), ammonium fluoride 0.5wt% (mass percent);

[0047] (4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial joint is used as the anode, the platinum sheet is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodization parameters are: voltage 40V, The...

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Abstract

The invention relates to a functionalized artificial joint with a selenium-loaded nanotube array surface. A titanium substrate surface of the artificial joint is provided with a sodium titanate nanotube array layer, and the inside of the sodium titanate nanotube array layer is further loaded with trace sodium selenite and bone morphogenetic protein. The preparation method of the artificial joint with the functionalized selenium-loaded nanotube array surface comprises the following steps: selecting pure titanium or titanium alloy to process the artificial joint; then adopting the two-step anodizing technology to obtain a titanium dioxide nanotube array layer with a tubular structure on the surface of the pure titanium or titanium alloy artificial joint; adopting the alkaline hydrothermal synthesis technology to convert the titanium dioxide nanotube array layer into the sodium titanate nanotube array layer; and finally adopting the centrifugal load technology to load the trace sodium selenite and the bone morphogenetic protein in the sodium titanate nanotube array layer of the surface of the artificial joint.

Description

technical field [0001] The present invention relates to an artificial joint functionalized with a selenium-loaded nanotube array surface and a preparation method thereof, in particular to an artificial joint matrix made of pure titanium or titanium alloy and sodium titanate loaded with trace element selenium and bone morphogenetic protein The artificial joint composed of nanotube surface layer and its preparation method belong to the technical field of artificial joint materials. Background technique [0002] Every year, about 1.5 million patients with joint loss due to degenerative and inflammatory arthritis need artificial joint replacement. Among them, the application of metal materials in the manufacture of artificial joints is the earliest, and it is still the most widely used in clinical practice. Over time and clinical studies have shown that artificial joints made of metal materials commonly loosen, sink or break, causing bone resorption, which is one of the main co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/06A61L27/56A61L27/54C25D11/26C01G23/00
Inventor 储成林饶席董寅生
Owner 江苏广达医材集团有限公司
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