Cinepazide maleate compound with novel route

A kind of technology of cinepazide maleate and compound, which can be applied in the field of medicine and can solve the problems of strong toxicity of solvent anhydrous benzene and the like
CN101774983AInactive Publication Date: 2010-07-14HAINAN MEILAN SMITH KLINE PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HAINAN MEILAN SMITH KLINE PHARMA
Publication Date
2010-07-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a cinepazide maleate compound with a novel route. Concretely, the method comprises the step of making 3, 4, 5-trimethoxy cinnamic acid and piperazidine take reaction in the existence of dichloromethyl (trichloromethyl) carbonic ether for producing 3, 4, 5-trimethoxy cinnamoyl piperazine. Through using the dichloromethyl (trichloromethyl) carbonic ether as acid activated groups, the invention simplifies the reaction steps, and reduces the environment pollution, in addition, the superfluous piperazidine is separated through the reaction with the piperazidine at first, and the processing steps are simplified, so the subsequent purification becomes easy.
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Description

technical field

[0001] The invention relates to a new route of cinepazide maleate compound, which belongs to the technical field of medicine. Background technique

[0002] Cinepazide Maleate, chemical name (E)-1-{4-[(3,4,5'-trimethoxycinnamoyl)]-1-piperazine}acetylpyrrolidine maleene dihydrochloride , molecular formula: C 22 h 31 N 3 o 5 ·C 4 h 4 o 4 , molecular weight: 533.58, chemical structural formula:

[0003]

[0004] Cinepazide maleate is a calcium ion channel blocker, by blocking Ca 2+ Transmembrane into vascular smooth muscle cells, relax vascular smooth muscle, dilate cerebral blood vessels, coronary blood vessels and peripheral blood vessels, thereby relieving vasospasm, reducing vascular resistance, and increasing blood flow. By increasing the blood flow of the cerebral vessels and improving the metabolism of the brain, it is clinically applicable to the treatment of cerebrovascular diseases, cardiovascular diseases and peripheral vascular diseases. ...

Claims

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