Drug composite for preventing diabetic nephropathy and preparation method thereof
A technique for diabetic nephropathy and its composition, which is applied in the field of preparation of drugs for preventing and treating diabetic nephropathy, can solve the problems of no reports, etc., and achieve the effects of clear structure, easy quality control, and prevention of the increase of blood creatinine
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Embodiment 1
[0035] Example 1: Preparation of mullein and mullein glycosides
[0036] Take 10 kg of dried astragalus medicinal materials, extract 3 times (2 hours, 1 hour, 1 hour) with 8 times the amount of 80% ethanol under reflux, filter, combine the filtrate, recover the solvent under reduced pressure, and concentrate until no alcohol taste to obtain the alcohol extract of astragalus. Placed in a refrigerator at 4°C overnight, the supernatant was adsorbed with D101 type macroporous resin, first eluted with pure water until the effluent was clear, and then eluted with 50% ethanol until TLC detected no verbasin spots. The 50% ethanol eluate was collected and concentrated under reduced pressure, and then extracted 7 times with an equal volume of ethyl acetate. After the extracts were combined, the solvent was recovered and dried under vacuum to obtain the total flavonoids of astragalus. The total flavonoids of Astragalus were then chromatographed on 200-300 mesh silica gel column with chlorof...
Embodiment 2
[0040] Example 2 Preparation of granules of pharmaceutical composition of the present invention (active ingredient is verbasil glycoside)
[0041] Verbascum glycosides 1mg
[0042] Starch 500mg
[0043] Microcrystalline cellulose 500mg
[0044] The preparation method: after mixing the verbasil glycosides with various auxiliary materials uniformly, the soft material is prepared with an appropriate amount of water, granulated, dried, granulated, and packed.
Embodiment 3
[0045] Example 3 Preparation of a tablet of the pharmaceutical composition of the present invention (active ingredient is verbasil glycoside)
[0046] Verbascum glycosides 20mg
[0047] Lactose 127mg
[0048] Corn starch 50mg
[0049] Magnesium stearate 3mg
[0050] Preparation method: Pass the Verbasil glycosides through an 80-mesh sieve, mix them with lactose and corn starch uniformly, add an appropriate amount of water and granulate the powder, after drying, the granules are sieved and mixed with other excipients, and then compressed into tablets. .
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