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Intravenous drug delivery system for ibuprofen and preparation method thereof

A technology of intravenous administration and preparation, which is applied in the direction of medical formula, antipyretics, anti-inflammatory agents, etc., can solve the problem of low activity of ibuprofen, and achieve the effect of good stability and feasible preparation process

Inactive Publication Date: 2010-07-28
HC SYNTHETIC PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Relatively low activity of ibuprofen in rats with adjuvant arthritis

Method used

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  • Intravenous drug delivery system for ibuprofen and preparation method thereof
  • Intravenous drug delivery system for ibuprofen and preparation method thereof
  • Intravenous drug delivery system for ibuprofen and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: the preparation of ibuprofen glucose injection (0.4g / 100ml)

[0022] Prescription: Ibuprofen 400g

[0023] Glucose 5kg

[0024] Adequate amount of arginine

[0025] Add water for injection to 100L

[0026]

[0027] 1000 bottles

[0028] 1) Receive qualified ibuprofen raw materials, glucose and arginine according to the ingredient list;

[0029] 2) Add water for injection with a batch volume of 95% in the batch tank, add glucose and ibuprofen in the batched amount, and slowly add arginine under stirring to adjust the pH value to about 7.4, add water for injection to the full amount, according to the total volume Add 0.05% (W / V) medicinal charcoal and stir evenly, keep warm for 20 minutes at 50°C to 80°C, and circulate and filter for more than 20 minutes;

[0030] 3) After the intermediates pass the test, notify the filling section to start filling;...

Embodiment 2

[0034] Embodiment 2: the preparation of ibuprofen sodium chloride injection (0.4g / 100ml)

[0035] Prescription: Ibuprofen 400g

[0036] Sodium chloride 0.9kg

[0037] Adequate amount of arginine

[0038] Add water for injection to 100L

[0039]

[0040] 1000 bottles

[0041] 1) Receive qualified ibuprofen raw materials, sodium chloride and arginine according to the ingredient list;

[0042] 2) Add water for injection with a batch volume of 95% in the batch tank, add glucose and ibuprofen in the batched amount, and slowly add arginine under stirring to adjust the pH value to about 7.5, add water for injection to the full amount, according to the total volume Add 0.05% (W / V) medicinal charcoal and stir evenly, keep warm for 20 minutes at 50°C to 80°C, and circulate and filter for more than 20 minutes;

[0043] 3) After the intermediates pass the test, notify the filling...

Embodiment 3

[0047] Embodiment 3: the preparation of ibuprofen sodium chloride injection (0.8g / 250ml)

[0048] Prescription: Ibuprofen 800g

[0049] Sodium chloride 2.25kg

[0050] appropriate amount of lysine

[0051] Add water for injection to 250L

[0052]

[0053] 1000 bottles

[0054] 1) Obtain qualified ibuprofen raw materials, sodium chloride and lysine according to the ingredient list;

[0055] 2) Add water for injection with a batch volume of 95% in the batch tank, add glucose and ibuprofen in the batched amount, and slowly add lysine under stirring to adjust the pH value to about 7.0, add water for injection to the full amount, according to the total volume Add 0.1% (W / V) medicinal charcoal and stir evenly, keep warm for 20 minutes at 50°C to 80°C, and circulate and filter for more than 20 minutes;

[0056] 3) After the intermediates pass the test, notify the filling sec...

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PUM

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Abstract

The invention relates to moxifloxacin hydrochloride glucose injection and the preparation method thereof. The preparation method comprises the following steps: A. adding injection water into the ingredient tank and a proper amount of auxiliary material and ibuprofen, B. stirring and adjusting the PH value with base regulator to 6.5 - 9.0. Adding injection water to the needed amount and stirring by activated carbon pole for needle injection, decarbonising the titanium stick and refine the solution by millipore filter. C. conducting the encapsulation after the pass of the test. D. delivering the encapsulated semi-product into the sterilization case for autoclave sterilization.

Description

Technical field: [0001] The invention relates to a preparation of an injection containing ibuprofen as a main medicinal component and a preparation method thereof. technical background: [0002] Ibuprofen has anti-inflammatory, analgesic and antipyretic effects. In many experiments using commonly used animals, the effect of ibuprofen is 16 to 32 times that of aspirin. In rats with adjuvant arthritis, ibuprofen has relatively low activity. Topical administration of human ibuprofen 300 mg reduces erythema associated with nicotinate furfurate emulsion application and is similar in this respect to aspirin and ibufenac but not sodium salicylate, phenylbutazone, and hydroxyphenylbutazone . [0003] The analgesia of ibuprofen is peripheral rather than central. This compound does not have glucocorticoid or adrenocorticoid stimulating properties. [0004] Ibuprofen injection (ibuprofen, Caldolor) was developed by Cumberland Company and was approved by FDA in the United States on ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/192A61K47/26A61K47/02A61P29/00
Inventor 杨成施维强建华
Owner HC SYNTHETIC PHARMA CO LTD
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