Application of total Elsholtzia splendens Nakai flavones extract of copper-polluted soil in preparation of vascular dilatation medicine

A technology of vasodilation and total flavonoids, which is applied in the direction of drug combination, cardiovascular system diseases, medical preparations containing active ingredients, etc., can solve the problems that there is no total flavonoids extract of A.

Inactive Publication Date: 2010-08-25
ZHEJIANG UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there is no published article on the vasodi...

Method used

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  • Application of total Elsholtzia splendens Nakai flavones extract of copper-polluted soil in preparation of vascular dilatation medicine
  • Application of total Elsholtzia splendens Nakai flavones extract of copper-polluted soil in preparation of vascular dilatation medicine
  • Application of total Elsholtzia splendens Nakai flavones extract of copper-polluted soil in preparation of vascular dilatation medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1, the influence of total flavonoid extract (TFES) of Rhizoma haizhou on the tension of thoracic aorta of rats pre-contracted by phenylephrine (PE)

[0033] The effect of TFES on the tension of PE pre-contracted aortic rings with intact endothelium (n=9): select vascular rings with intact endothelium, add PE (1 μmol / L) to the pre-contracted rat thoracic aorta to reach a steady state, and add TFES cumulatively , so that the concentration of TFES in the perfusate reaches 5, 10, 25, 50, 100, and 200 μg / ml respectively; the change of vascular tension is reflected by the ratio between the vascular tension amplitude after adding TFES and the maximum contraction amplitude of the vascular ring induced by PE , to plot TFES concentration-relaxation curves of TFES on PE-precontracted endothelial intact aortic rings. Effect of TFES on the tension of PE pre-contracted aortic rings (n=9): use the endothelial-removed vascular rings, and draw the TFES concentration-relaxatio...

Embodiment 2

[0036] Embodiment 2, the influence of total flavonoids extract (TFES) of Rhizoma haizhou on the tension of KCl pre-contracted rat thoracic aorta

[0037] The effect of TFES on the tension of endothelial intact KCl pre-contracted aortic rings group (n=9): select the vascular rings with intact endothelium, pre-contract with KCl (60mmol / L) to reach a steady state, add TFES by accumulative dosing method, make perfusion The concentration of TFES in the solution reached 5, 10, 25, 50, 100, and 200 μg / ml respectively; the ratio of the vascular tension amplitude after adding TFES to the maximum contraction amplitude of the KCl-induced vascular ring reflects the change of vascular tension, and draws TFES TFES concentration-relaxation curves of PE-precontracted endothelial intact aortic rings. The effect of TFES on the tension of endothelial KCl pre-contracted aortic rings group (n=8): the endothelial vascular rings were removed, and the other methods were the same as above, and the TFE...

Embodiment 3

[0040] Example 3, Time Dependence of TFES on the Relaxation Effect of Rat Isolated Thoracic Aorta Vascular Ring

[0041] Choose intact endothelium, pre-shrink the aortic ring with intact endothelium with PE (1 μmol / L) to reach a steady state, add TFES (0.05 g / ml) to make the perfusate concentration reach 100 μg / ml, record changes in vascular tension every 3 minutes; The endothelial aortic ring was pre-shrunk with PE (1 μmol / L) to reach a steady state after the endothelial aortic ring was removed, and the method was the same as above, and the change of vascular tension was recorded every 3 minutes; whether there was a time-dependence of the vasodilator effect of TFES was determined (Figure 3).

[0042] The results showed that the vascular ring with complete endothelium was pretreated with PE, and the tension change of the blood vessel was observed under the environment of maintaining the concentration of TFES at 100 μg / ml. The maximum relaxation degree of the vascular endotheliu...

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Abstract

The invention discloses application of total Elsholtzia splendens Nakai flavones extract of copper-polluted soil in the preparation of a vascular dilatation medicine. The vascular dilatation effect of the total Elsholtzia splendens Nakai flavones is obviously superior to that of total Hangzhou white chrysanthemum flavones extract, total ginkgo flavones and total soybean flavones.

Description

technical field [0001] The invention relates to the application of the total flavonoid extract of Rhizoma haizhou from copper-polluted soil in the preparation of vasodilators. Background technique [0002] The green phytoremediation technology of heavy metal polluted soil is to absorb and fix CO in the air by making full use of solar energy through plant photosynthesis 2 , converted into carbon in biomass; at the same time, by harvesting a large amount of heavy metal-rich biomass, the purpose of taking away heavy metals in the soil is achieved; it is a bio-environmental protection innovation technology with the advantages of low cost, high efficiency, environmental friendliness, green and low carbon, etc. It has been highly recognized by governments and scientists at all levels at home and abroad. my country's copper-enriched plant, Cyperus haizhou, can tolerate high copper in polluted soil, significantly reduce the content of water-soluble or acetic acid-extracted copper i...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P9/08
Inventor 章国林王会平彭红云杨肖娥石伟勇
Owner ZHEJIANG UNIV
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