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Method for preparing beta-calcium phosphate or hydroxyapatite nanoparticles

A hydroxyapatite and nanoparticle technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve the problems of complex reaction, high cost, poor micro-mixing of materials, etc., to achieve good repeatability and stability, The effect of large production capacity and low production cost

Active Publication Date: 2011-12-28
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the above-mentioned methods all have their own shortcomings. The solid-phase method, microemulsion method, and alkoxide hydrolysis method can prepare nanoparticles with small particle size and high purity, but the reaction is complicated and the cost is high; although the direct precipitation method has low cost, However, the particle size of the prepared particles is too large, the monodispersity is not good, and the purity is not high.
The reason for this situation in the direct precipitation method is that the microscopic mixing of the materials is poor, the particle growth is difficult to control during direct precipitation, and the product is easy to cause wrapping on calcium sources with poor water solubility such as calcium hydroxide, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Prepare 1000g of calcium hydroxide suspension with a solid content of 75g / L as a calcium source, and make it circulate at a flow rate of 1.6m / s;

[0021] 2) Prepare 330g of phosphoric acid aqueous solution with a mass fraction of 20% as a phosphorus source. Under pressure, phosphoric acid aqueous solution is passed through micropores with an equivalent diameter of 5 microns at a flow rate of 0.5m / s, and then added to the above-mentioned calcium hydroxide from a vertical direction In the suspension, make the phosphorus source and the calcium source cross-flow;

[0022] 3) After the aqueous phosphoric acid solution is sheared by the calcium hydroxide suspension flowing in cross-flow, it is mixed and reacted to form the precursor precipitation of β-calcium phosphate; then it is matured, filtered, washed with water to remove impurities, dried, calcined, and pulverized to obtain β-calcium phosphate - Calcium phosphate nanoparticles with an average length of 110 nm and an ...

Embodiment 2

[0025] 1) Prepare 1000 g of calcium hydroxide suspension with a solid content of 15 g / L as a calcium source, and make it circulate at a flow rate of 0.6 m / s;

[0026] 2) Prepare 164g of phosphoric acid aqueous solution with a mass fraction of 5% as a phosphorus source. Under pressure, phosphoric acid aqueous solution is passed through micropores with an equivalent diameter of 0.2 microns at a flow rate of 0.5m / s, and then added to the above-mentioned calcium hydroxide from a vertical direction. In the suspension, make the phosphorus source and the calcium source cross-flow;

[0027] 3) After the aqueous phosphoric acid solution is sheared by the calcium hydroxide suspension flowing in cross-flow, it is mixed and reacted to form the precursor precipitation of β-calcium phosphate; then it is matured, filtered, washed with water to remove impurities, dried, calcined, and pulverized to obtain β-calcium phosphate - Calcium phosphate nanoparticles having an average length of 82 nm a...

Embodiment 3

[0029] 1) Prepare 1000g of calcium hydroxide suspension with a solid content of 150g / L as a calcium source, and make it circulate at a flow rate of 20m / s;

[0030] 2) Prepare 600 mL of ammonium dihydrogen phosphate aqueous solution with a concentration of 2.0 mol / L as a phosphorus source. Direction is added to the above-mentioned calcium hydroxide suspension to make the phosphorus source and the calcium source cross-flow;

[0031] 3) After the ammonium dihydrogen phosphate aqueous solution is sheared by the calcium hydroxide suspension flowing in cross-flow, it is mixed and reacted to form hydroxyapatite precipitation; then it is matured, filtered, washed with water to remove impurities, dried, calcined, and crushed to obtain hydroxyl apatite Apatite nanoparticles with an average length of 40nm.

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Abstract

The invention provides a method for preparing beta-calcium phosphate or hydroxyapatite nanoparticles, which comprises: dispersing a phosphorous source in a calcium source which flows circularly in a vertical direction from micropores to make the phosphorous source and the calcium source flow in a crossed way; and allowing the phosphorous source to mix and react with the calcium source which flowsacross after the phosphorous source is sheared by the calcium source to prepare the beta-calcium phosphate or hydroxyapatite nanoparticles, wherein the phosphorous source is aqueous solution of phosphoric acid or ammonium dihydrogen phosphate and the calcium source is turbid liquid of calcium hydroxide. The method of the invention, which prepares the beta-calcium phosphate or hydroxyapatite nanoparticles by using a micropore dispersion method of shearing by liquid phase cross flows, has the advantages of high production cost, high productivity, simple and convenient operation, high repeatability and stability; and the method can prepare the beta-calcium phosphate or hydroxyapatite nanoparticles which have controllable size and uniform distribution.

Description

technical field [0001] The invention relates to a preparation method of β-calcium phosphate or hydroxyapatite nanoparticles, in particular to a micropore dispersion method using liquid phase cross-flow shearing to prepare β-calcium phosphate or hydroxyapatite nanoparticles particles. Background technique [0002] Both β-calcium phosphate and hydroxyapatite nanoparticles have special properties such as good biological activity and surface effect, and are widely used in optoelectronic materials, special ceramics, catalyst carriers, lasers and fuel cells and other fields. At present, there are two main methods for the preparation of β-calcium phosphate or hydroxyapatite nanoparticles: (1) solid-phase method: using calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate and calcium phosphate as raw materials, at 1200-1300 Under the temperature of ℃, the steam is passed through for 2-3 hours. (2) Liquid phase method: It can be divided into three types: direct preci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32
Inventor 骆广生杜乐吕阳成王玉军
Owner TSINGHUA UNIV
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