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Novel medicinal composition and preparation method

A technology of composition and medicine, which is applied in the field of new pharmaceutical composition and preparation, can solve the problems of weak inductive ability, achieve the effects of reducing dosage, low treatment cost and increasing anti-lung cancer effect

Inactive Publication Date: 2010-10-06
天津泽世德生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Astragalus polysaccharide alone can induce the production of endogenous interferon, but the induction ability is weak; Newcastle disease virus has a significant effect on inducing interferon-α; the combination of astragalus polysaccharide and Newcastle disease virus has a stronger induction ability, resulting in a synergistic effect, far higher for separate use

Method used

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  • Novel medicinal composition and preparation method
  • Novel medicinal composition and preparation method

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Experimental program
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Effect test

specific Embodiment 1

[0029] (1) Selection and cultivation of chicken Newcastle disease virus

[0030] Chicken Newcastle disease virus is selected, cultured in the allantoic fluid of 10-12 day old live chicken embryos at 37-38° C. for 48-72 hours, and then the allantoic fluid containing the virus is collected.

[0031] The titer was determined by the hemagglutination method, and then the titer of the chicken Newcastle disease virus allantoic fluid determined was adjusted to 1:640.

[0032] The impurities, protein, contaminated bacteria and part of urate in the allantoic fluid of chicken embryos are removed through a closed double-layer poplin bag and a 0.22 μm microporous membrane filter.

[0033] (2) Preparation of preparation components

[0034] A: Glycoprotein G 1 0.72 g Glycoprotein G 2 0.36 grams

[0035] Dissolve in 160 ml of 0.075NHCL solution in sequence, and place in a water bath for half an hour.

[0036] B: Biotin 1.0mg

[0037] Dissolve in 7.5 ml of deionized water first, add 0.1 ...

specific Embodiment 2

[0069] (1) Selection and cultivation of chicken Newcastle disease virus

[0070] Chicken Newcastle disease virus is selected, cultured in the allantoic fluid of 10-12 day old live chicken embryos at 37-38° C. for 48-72 hours, and then the allantoic fluid containing the virus is collected.

[0071] The titer was determined by the hemagglutination method, and then the titer of the chicken Newcastle disease virus allantoic fluid determined was adjusted to 1:640.

[0072] The impurities, protein, contaminated bacteria and part of urate in the allantoic fluid of chicken embryos are removed through a closed double-layer poplin bag and a 0.22 μm microporous membrane filter.

[0073] (2) Preparation of preparation components

[0074] A: Glycoprotein G 1 0.72 g Glycoprotein G 2 0.36 grams

[0075] Dissolve in 160 ml of 0.075NHCL solution in sequence, and place in a water bath for half an hour.

[0076] B: Biotin 1.0 mg

[0077] Dissolve in 7.5 ml of deionized water first, add 0.1...

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Abstract

The invention relates to a novel medicinal composition for improving organism immune function and resisting tumor to address both the symptoms and root cause, and a preparation method. The medicinal composition comprises the following components: 1,500 milliliters of Newcastle disease virus allantoic fluid with a titer of 1:640, 2 milliliters of neuraminidase, 2 milliliters of nuclease, 1.08 grams of glycoprotein G, 10 grams of galactose, 1.0 milligrams of biotin, 5 grams of fucose, 15 grams of astragalus polysaccharide, 2.0 milligrams of sialidase, 2.0 milligrams of phospholipid, 10 milligrams of uracil, 5 milligrams of Vit C, 4.0 milligrams of cholesterol, 200 milligrams of ATP, 22 milliliters of 10 percent KCl, 3.6 grams of MgSO4.7H2O, and 10 milligrams of prothrombin. The experiments for pharmacodynamics, pharmacology and the like, show that the medicinal composition has good inhibiting and killing effects on mouse transplantable tumor such as Lewis lung carcinoma. Compared with the medicament of the conventional invention, the medicinal composition has more remarkable diffidence in the growth inhibiting effect on the mouse Lewis lung carcinoma. The medicinal composition has obvious effect, and is a novel biological anticancer preparation with good social and economic benefits.

Description

technical field [0001] The invention relates to a new anticancer drug composition with high efficiency and broad spectrum and a preparation method. The pharmaceutical composition prepared by the invention has more obvious therapeutic effect on cancers such as lung cancer. Background technique [0002] Drugs with high anti-tumor effect and low side effects have not been found yet. Macrophages, cytotoxicity, T lymphocytes, natural killer cells, hybridoma cells secreting monoclonal antibodies, interleukins, interferons, tumor necrosis factors, immunoglobulins and other cytotoxic active cells produced by modern cell engineering technology And cytokines, their common role is mainly adoptive immunity, in order to achieve the purpose of anti-tumor. [0003] The DNA polymerase and RNA polymerase activities of cancer cells are higher than normal cells, so the synthesis of nucleic acid by cancer cells is enhanced. In contrast, the decomposition process of cancer cell nucleic acid w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/46A61P35/00A61K35/76A61K36/481
Inventor 古长庆张炳团
Owner 天津泽世德生物医药有限公司
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