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Method for preparing artificial nucleus pulposus prosthetic material

A prosthetic material and intervertebral disc technology, applied in prosthetics, medical science, etc., can solve the problems of poor adhesion between the outer capsule material and the filling material, peeling and breaking of the outer capsule material, lack of biocompatibility, etc., and achieve molding processing And the effect of convenient clinical operation, good mechanical properties and long service life

Inactive Publication Date: 2010-11-03
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this kind of prosthesis has the disadvantage of poor adhesion between the outer capsule material and the filling material, and there is a hidden danger that the outer capsule material is easily peeled off and broken after long-term use.
Once the outer capsule material is broken, the biocompatibility of the inner core material composed entirely of silica gel is also at risk due to the lack of long-term evaluation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] The preparation method that the present invention proposes is used for intervertebral disc nucleus pulposus prosthesis material, comprises the following steps:

[0019] (1) Synthetic silicon-containing polyurethane capsule material:

[0020] Mix the first polymer diol, siloxane and diisocyanate, the molar ratio of mixing is: polymer diol: siloxane: diisocyanate = 0.1~0.6:0.6~0.1:1, under nitrogen protection Stir and mix at 60-85°C for 1-4 hours to obtain a prepolymer; raise the temperature to 80-120°C, add a chain-extending cross-linking agent, and add a molar ratio: chain-extending cross-linking agent: diisocyanate = 0.30: 1-0.80:1, stirring and reacting for about 2-12 minutes to discharge; aging the obtained polymer at 90-100°C for 3-12 hours;

[0021] (2) Prepare polyurethane capsule:

[0022] Process the polyurethane material into a flat ellipsoid by blow molding or molding;

[0023] (3) Preparation of silicon-containing polyurethane filler:

[0024] Make the fo...

Embodiment 1

[0053] (1) Preparation of polyurethane capsule:

[0054] Mix polytetrahydrofuran ether diol with a molecular weight of 650, polydimethylsiloxane with a molecular weight of 944, and 4,4'-diphenylmethane diisocyanate previously vacuum dehydrated, and the molar ratio of mixing is 0.12:0.48: 1. Under nitrogen protection, stir and mix at 80°C for 2 hours to obtain a prepolymer; raise the temperature to 90°C, add pre-dehydrated 1,4-butanediol, which is mixed with 4,4'-diphenylmethane The molar ratio of isocyanate is 0.4:1, the reaction is stirred for about 6 minutes and the material is discharged; the obtained polymer is aged at a temperature of 100°C for 12 hours.

[0055] (2) Molding and processing of polyurethane capsule:

[0056] The polyurethane material is processed into hollow capsules by blow molding or compression molding. The formed capsule has the following characteristics: the shape is a flat ellipsoid, and the length and width are obviously greater than the height. A...

Embodiment 2

[0062] (1) Preparation of polyurethane capsule:

[0063] Mix polytetrahydrofuran ether diol with a molecular weight of 1000, polydimethylsiloxane with a molecular weight of 944, and 4,4'-diphenylmethane diisocyanate previously vacuum dehydrated, and the molar ratio of mixing is 0.13:0.52: 1. Under nitrogen protection, stir and mix at 80°C for 2 hours to obtain a prepolymer; raise the temperature to 90°C, add pre-dehydrated 1,4-butanediol, which is mixed with 4,4'-diphenylmethane The molar ratio of isocyanate is 0.35:1, the reaction is stirred for about 5 minutes and the material is discharged; the obtained polymer is aged at a temperature of 100°C for 12 hours.

[0064] (2) Molding and processing of polyurethane capsule:

[0065] The polyurethane material is processed into hollow capsules by blow molding or compression molding. The formed capsule has the following characteristics: the shape is a flat ellipsoid, and the length and width are obviously greater than the height. ...

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Abstract

The invention relates to a method for preparing an artificial nucleus pulposus prosthetic material, and belongs to the technical field of high polymer materials. The method comprises the following steps of: synthesizing a silicon-containing polyurethane capsule material; preparing a polyurethane capsule and a silicon-containing polyurethane filler; and planting the silicon-containing polyurethanefiller in the polyurethane capsule. In the preparation method, the external capsule of the nucleus pulposus is made of the thermoplastic silicon-containing (or silicon-free) polyurethane, and the silicon-containing polyurethane cured at room temperature is used as a filling material in the capsule. The polyurethane external capsule is formed in vitro, and the silicon-containing polyurethane curedat room temperature is injected into a human body in a liquid form and then is polymerized in situ. The external capsule and the filling material prepared by the method have the advantages of excellent mechanical properties, good biocompatibility, convenient fabricated operation and clinical operation and the like, and also have excellent adhesion; and the silicon element introduced also greatly prolongs the service life of the nucleus pulposus prosthesis in a human body.

Description

technical field [0001] The invention relates to a preparation method for an artificial intervertebral disc nucleus pulposus prosthesis material, belonging to the technical field of polymer materials. Background technique [0002] Lumbar nucleus pulposus replacement is a new method for the treatment of lumbar degenerative diseases in recent years. This method can not only overcome the shortcomings of lumbar fusion, but also preserve the motor function of the spine. The artificial nucleus pulposus that has been clinically applied at present is a hydrogel-type externally formed prosthetic nucleus pulposus, that is, the shape and size of the nucleus pulposus are preformed in vitro, and then implanted into the body to absorb water and expand to form. The most typical representative is the hydrogel nucleus pulposus prosthesis developed by American Raymedia Corporation (Ray CD. The PDN prosthetic disc-nucleus device. Eur Spine J 2002, 11: 137-142). However, the large fibrous annu...

Claims

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Application Information

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IPC IPC(8): A61L27/18
Inventor 刘堃张永昌庹新林
Owner TSINGHUA UNIV
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