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Doxorubicin hydrochloride-carrying natural polymer-poly(3-benzene acid acrylamide) composite nanospheres, manufacturing method and application thereof

A technology of acrylamidophenylboronic acid and natural polymers, which is applied in the direction of non-active ingredients of polymer compounds, preparation of microspheres, medical preparations of non-effective ingredients, etc., to achieve stable chemical properties, strong drug sustained release function, and biophase good capacitive effect

Active Publication Date: 2013-02-06
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, natural polymer-poly(3-acrylamidophenylboronic acid) composite nanospheres have not been reported

Method used

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  • Doxorubicin hydrochloride-carrying natural polymer-poly(3-benzene acid acrylamide) composite nanospheres, manufacturing method and application thereof
  • Doxorubicin hydrochloride-carrying natural polymer-poly(3-benzene acid acrylamide) composite nanospheres, manufacturing method and application thereof
  • Doxorubicin hydrochloride-carrying natural polymer-poly(3-benzene acid acrylamide) composite nanospheres, manufacturing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of dextran-poly(3-acrylamidophenylboronic acid) composite nanospheres

[0030] In a 25 ml stirred reactor, 90 mg of 3-acrylamidophenylboronic acid and 152 mg of dextran with a number average molecular weight of 3000 were dissolved in 12 ml of distilled water. After cooling to room temperature, 9.4 mg of 4,4'-azo (4-cyanovaleric acid) initiator was added. The temperature was raised to 80°C, and the polymerization reaction was initiated for 2 hours to obtain an aqueous solution of dextran-poly(3-acrylamidophenylboronic acid) composite nano-microspheres. The reaction was stopped, the temperature of the system was lowered to room temperature, and the aqueous dispersion was put into a dialysis bag (Cut-off molecular weight is 12000) and dialyzed for 24 hours to remove unreacted monomers in the system. The average particle size of the nanospheres measured by dynamic light scattering is 72.5±2.0 nm. Among them, natural polymers accounted for 9.1%, and pol...

Embodiment 2

[0031] Example 2: Preparation of dextran-poly(3-acrylamidophenylboronic acid) composite nanospheres

[0032] In a 25 ml stirred reactor, 90 mg of 3-acrylamidophenylboronic acid and 76 mg of dextran with a number average molecular weight of 3000 were dissolved in 12 ml of distilled water. After cooling to room temperature, 9.4 mg of 4,4'-azo (4-cyanovaleric acid) initiator was added. The temperature was raised to 80°C, and the polymerization reaction was initiated for 2 hours to obtain an aqueous solution of dextran-poly(3-acrylamidophenylboronic acid) composite nano-microspheres. The reaction was stopped, the temperature of the system was lowered to room temperature, and the filtration was carried out. After filtration, the aqueous dispersion was put into a dialysis bag (Cut-off molecular weight is 12000) and dialyzed for 24 hours to remove unreacted monomers in the system. The average particle size of the nano-microspheres measured by dynamic light scattering is 77.4±2.1 nm, of...

Embodiment 3

[0033] Example 3: Preparation of dextran-poly(3-acrylamidophenylboronic acid) composite nanospheres

[0034] In a 25 ml stirred reactor, 90 mg of 3-acrylamidophenylboronic acid and 38 mg of dextran with a number average molecular weight of 3000 were dissolved in 12 ml of distilled water. After cooling to room temperature, 9.4 mg of 4,4'-azo (4-cyanovaleric acid) initiator was added. The temperature was raised to 80°C, and the polymerization reaction was initiated for 2 hours to obtain an aqueous solution of dextran-poly(3-acrylamidophenylboronic acid) composite nano-microspheres. The reaction was stopped, the temperature of the system was lowered to room temperature, and the filtration was carried out. After filtration, the aqueous dispersion was put into a dialysis bag (Cut-off molecular weight is 12000) and dialyzed for 24 hours to remove unreacted monomers in the system. The average particle size of the nano-microspheres measured by dynamic light scattering is 65.1±0.1 nm, of...

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Abstract

The invention discloses natural polymer-poly(3-benzene acid acrylamide) composite nanospheres. The surfaces of the natural polymer-poly(3-benzene acid acrylamide) composite nanospheres are hydrophilic natural polymers; the interiors are hydrophobic poly(3-benzene acid acrylamide); the number average molecular weight of the natural polymer is in a range of between 2,000 and 100,000; the content of the natural polymer is 5 to 70 percent of the mass of the composite nanospheres; the number average molecular weight of the poly(3-benzene acid acrylamide) is in a range of between 1,000 and 10,000; the content of the poly(3-benzene acid acrylamide) is 30 to 95 percent of the mass of the composite nanospheres; and the average grain diameter of the composite nanospheres is of between 40 and 100 nanometers. The composite nanospheres of the invention have the characteristics of high biocompatibility and stable chemical properties. The composite nanospheres of the invention can be used as a medicament carrier, has a sustained-release effect, and can be used as a carrying agent in a boron neutron capture therapy. The invention also discloses a manufacturing method for the composite nanospheres.

Description

Technical field [0001] The invention relates to a biodegradable natural polymer-poly(3-acrylamidophenylboronic acid) composite nano-microsphere, which can be used as boron neutron capture therapy, and can also be used as a drug carrier. Background technique [0002] Boron neutron capture therapy (BNCT) is a treatment that destroys cancer cells through nuclear reactions in tumor cells. Its treatment principle is to inject isotope into tumor patient first 10 Boron, which accumulates in tumor cells after entering the body, is rarely distributed in other tissues. This boron-containing compound is non-toxic to the human body and has no therapeutic effect on cancer. A thermal neutron beam is used to irradiate the tumor site, one during neutron irradiation 10 Boron atom absorbs 1 neutron and becomes 11 The boron atom undergoes nuclear fission and the fission releases alpha particles ( 4 He) and lithium atoms ( 7 Li). Alpha particles are highly lethal rays, which can effectively kill t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02A61K41/00A61K47/32A61K47/36A61K47/38A61K47/42A61K31/704A61P35/00
Inventor 蒋锡群张鲁中武伟王晶
Owner NANJING UNIV
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