Aminopyrine production method

A technology of aminopyrine and production method, which is applied in the direction of organic chemistry, can solve the problems of complex operation of the production method, affecting the yield of aminopyrine, and high energy consumption, so as to save the time of cooling crystallization and centrifugation, and improve the quality of hydrogenation , the effect of guaranteed yield
CN101891683AInactive Publication Date: 2010-11-24JIHENG PHARMA HENGSHUI CITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIHENG PHARMA HENGSHUI CITY
Publication Date
2010-11-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an aminopyrine production method, which comprises the following steps of: the preparation of sulfuric acid antipyrine, nitrosation, first hydrogenation reduction reaction, second hydrogenation reduction reaction, and decoloring, crystallization and drying performed on the crude product of the aminopyrine obtained by the second hydrogenation reduction reaction. Filter-pressing reaction is added between the first hydrogenation reduction reaction step and the second hydrogenation reduction reaction step, and comprises the following steps of: adding activated carbon and the oily 4-amino antipyrine obtained in the first hydrogenation reduction reaction step into a decoloring tank, controlling the temperature to be 80 to 90 DEG C, stirring the solution, adjusting a pH value to be 7.0 to 7.5, and then performing the filter-pressing on the solution in the decoloring tank with a three-liner filter to obtain 4-amino antipyrine filter-pressing liquid. The method has the advantages of improving the yield of the aminopyrine at the premise of ensuring the quality of the product, improving the working environment, saving labor, reducing labor intensity, saving energy, reducing emission and reducing the production cost.
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Description

technical field

[0001] The invention relates to a production method of aminopyrine. Background technique

[0002] In the prior art, the production method of aminopyrine comprises the following steps,

[0003] The preparation of antipyrine sulfate, antipyrine and sulfuric acid molar ratio is 2: 1 ratio reacts to obtain antipyrine sulfate; Nitrosation reaction, carries out nitrosation with described antipyrine sulfate and sodium nitrite Reaction, obtain nitroso antipyrine, the mass ratio of described antipyrine sulfate and sodium nitrite is 1: 0.35~0.40; The first hydrogenation reduction reaction, described nitroso antipyrine in catalyst Reynolds nickel Under the action of hydrogenation, feed hydrogen to carry out hydrogenation reduction reaction to obtain 4-aminoantipyrine oily substance; crystallization, put the 4-aminoantipyrine oily substance cooling crystallization obtained in the first hydrogenation reduction reaction step into the crystallization tank, open Cool the c...

Claims

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