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Dexpanthenol infusion preparation and preparation method thereof

A technology of dexpanthenol and its preparations, which is applied in the field of dexpanthenol infusion preparations and its preparation, can solve the problems of dexpanthenol infusion preparation research and market reports that have not been seen, and achieve simple and feasible operation, controllable quality, and overcome the pH value unstable effect

Active Publication Date: 2013-03-06
河北凯盛医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there is no research and market report of dexpanthenol infusion preparations at home and abroad.

Method used

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  • Dexpanthenol infusion preparation and preparation method thereof
  • Dexpanthenol infusion preparation and preparation method thereof
  • Dexpanthenol infusion preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Weigh 11.8g of sodium acetate trihydrate, add an appropriate amount of water for injection to dissolve; measure 2.8ml of glacial acetic acid and add, quantify to 2,000ml, and measure the pH value to be 4.01. Weigh 15g of sodium chloride and add, stir until completely dissolved.

[0077] Weigh 10g of dexpanthenol, add the above solution to about 1,600ml, stir until completely dissolved; take 0.01% activated carbon for needles, stir at room temperature for 15min and then filter; Sodium solution, so that the concentration is 1ml: 5mg; sterilized by filtration through a 0.22μm microporous membrane; potting, the volume of each bottle is 100ml; sterilized by autoclaving at 121°C for 8 minutes, inspected, printed, and packaged.

Embodiment 2

[0079] Weigh 2.14g of sodium acetate trihydrate, add an appropriate amount of water for injection to dissolve; measure 1.6ml of glacial acetic acid, add it to 2,000ml, and measure the pH value to 4.51. Weigh 15g of sodium chloride and add, stir until completely dissolved.

[0080] Weigh 10g of dexpanthenol, add the above solution to about 1,600ml, stir until completely dissolved; take 0.05% activated carbon for needles, stir at room temperature for 20min and then filter; Sodium solution, so that the concentration is 1ml: 5mg; sterilized by filtration through a 0.22μm microporous membrane; potting, the volume of each bottle is 100ml; sterilized by autoclaving at 121°C for 12min, inspected, printed, and packaged.

Embodiment 3

[0082] Weigh 3.38g of sodium acetate trihydrate, add an appropriate amount of water for injection to dissolve; measure 0.8ml of glacial acetic acid, add it to 2,000ml, and measure the pH value to 4.98. Weigh 15.2 g of sodium chloride and add, and stir until completely dissolved.

[0083] Weigh 10g of dexpanthenol, add the above solution to about 1,600ml, stir until completely dissolved; take 0.10% activated carbon for needles, stir at room temperature for 25min and then filter; Sodium solution, so that the concentration is 1ml: 5mg; sterilized by filtration through a 0.22μm microporous membrane; potting, the volume of each bottle is 100ml; sterilized by autoclaving at 121°C for 15 minutes, inspected, printed, and packaged.

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Abstract

The invention discloses a dexpanthenol infusion preparation and a preparation method thereof. The infusion is prepared from an active ingredient of dexpanthenol and an isotonic solvent with a certain pH value through high-temperature sterilization. The research of the new preparation successfully solves the secondary pollution problem in the use process of medicines so that the clinical application of the dexpanthenol is safer, highly efficient and more convenient. The infusion used as a preventive agent can reduce the possibility of generating paralytic ileus after a larger abdomen surgical operation and can be used for abdominal distension caused by intestinal weakness, postoperative or puerperal flatus or postoperative delay of intestinal motility recovery, and the like.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a dexpanthenol transfusion preparation and a preparation process thereof. Background technique [0002] Dexpanthenol (English name: dexpanthenol; chemical name: D-(+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide), the chemical structural formula is: [0003] [0004] Dexpanthenol is a cholinergic drug, an N-choline receptor agonist, which can restore muscle strength. In addition, this product is easily converted into pantothenic acid in the body and participates in biochemical reactions, forming coenzyme A, promoting the absorption of vitamin B, and playing an important role in the metabolism of sugar, fat and protein. Clinically, it is mainly used for gastrointestinal relaxation, and various mild skin diseases, such as neurodermatitis, simple conjunctivitis, etc. It is also used to reduce the side effects of streptomycin and salicylate. In a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/164A61K47/02A61K47/12A61P1/00A61P17/00A61P27/02
Inventor 赵凯李新苑洪忠侯建平
Owner 河北凯盛医药科技有限公司
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