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Dually-targeted pH-sensitive antineoplastic drug carrier material as well as preparation and application thereof

An anti-tumor drug, dual-targeting technology, applied to a new drug carrier material and its preparation method and application field, to achieve the effects of avoiding a large amount of release, high-efficiency loading, and large specific surface area

Inactive Publication Date: 2011-01-12
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, most of the existing studies can only achieve one targeted delivery. Therefore, here we prepared a drug carrier based on multifunctional single-layer graphite oxide with dual targeted delivery functions and pH-controlled release performance. Material

Method used

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  • Dually-targeted pH-sensitive antineoplastic drug carrier material as well as preparation and application thereof
  • Dually-targeted pH-sensitive antineoplastic drug carrier material as well as preparation and application thereof
  • Dually-targeted pH-sensitive antineoplastic drug carrier material as well as preparation and application thereof

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Experimental program
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Embodiment 1

[0037] The first step: Synthesize single-layer graphite oxide material, the preparation process can refer to (ACSNano, 2008, 2, 463-470); the core of this step is to obtain single-layer graphite oxide material. Similarly, other methods for obtaining single-layer graphite materials can also be used.

[0038] The second step: the preparation of single-layer graphite oxide-triferromagnetic nanoparticle composite hybrid material:

[0039] Disperse 40 mg of single-layer graphite oxide in 100 mL of dilute sodium hydroxide solution, adjust the pH to 12, react for 12 hours, and dialyze with a dialysis bag until the dialyzed fluid becomes neutral. Use nitrogen protection to have the monolayer graphite oxide aqueous solution of carboxylic acid sodium salt, add 48mg hexahydrate ferric chloride and 2.4g tetrahydrate ferric chloride mixture of nitrogen protection, stir 12 hours under nitrogen protection, centrifuge the reaction mixture Wash with water to remove excess iron salt, disperse ...

Embodiment 2

[0054] The first step: Synthesize single-layer graphite oxide material, the preparation process can refer to (ACSNano, 2008, 2, 463-470); the core of this step is to obtain single-layer graphite oxide material. Similarly, other methods for obtaining single-layer graphite materials can also be used.

[0055] The second step: the preparation of single-layer graphite oxide-triferromagnetic nanoparticle composite hybrid material:

[0056] Disperse 40 mg of single-layer graphite oxide in 100 mL of dilute sodium hydroxide solution, adjust the pH to 12, react for 12 hours, and dialyze with a dialysis bag until the dialyzed fluid becomes neutral. Use nitrogen to protect the single-layer graphite oxide aqueous solution with carboxylic acid sodium salt, add nitrogen-protected 18mg hexahydrate ferric chloride and 400mg tetrahydrate ferric chloride mixture, stir for 12 hours under nitrogen protection, centrifuge the reaction mixture with water Wash to remove excess iron salt, disperse th...

Embodiment 3

[0068] The first step: Synthesize single-layer graphite oxide material, the preparation process can refer to (ACSNano, 2008, 2, 463-470); the core of this step is to obtain single-layer graphite oxide material. Similarly, other methods for obtaining single-layer graphite materials can also be used.

[0069] The second step: the preparation of single-layer graphite oxide-triferromagnetic nanoparticle composite hybrid material:

[0070] Disperse 40 mg of single-layer graphite oxide in 100 mL of dilute sodium hydroxide solution, adjust the pH to 12, react for 12 hours, and dialyze with a dialysis bag until the dialyzed fluid becomes neutral. Use nitrogen to protect the single-layer graphite oxide aqueous solution with carboxylic acid sodium salt, add nitrogen-protected 36mg hexahydrate ferric chloride and 600mg tetrahydrate ferric chloride mixture, stir for 12 hours under nitrogen protection, centrifuge the reaction mixture with water Wash to remove excess iron salt, disperse th...

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Abstract

The invention relates to a dually-targeted pH-sensitive antineoplastic drug carrier material as well as a preparation method and an application thereof. The dually-targeted pH-sensitive antineoplastic drug carrier material takes a monolayer graphite oxide material and a mixture of divalent molysite and trivalent molysite as raw materials and is prepared by a chemical deposition method as follows: preparing the raw materials into a super paramagnetic monolayer graphite oxide and ferroferric oxide nano composite hybrid material; and then connecting a folic acid molecule capable of interacting with the folate receptor of a cancer cell surface onto the surface of a ferroferric oxide nano particle, thereby obtaining the high-efficiency dually-targeted drug carrier material with pH controlled release performance. After being loaded with various antineoplastic drugs, the material of the invention obtains higher capacity, has better pH controlled release performance displayed by in-vitro release experiments, and has better targeting action and antipersonen to cancer cells with highly expressed folate receptors. The invention has wide application prospect in the aspect of delivering multiple targeted drugs and drugs with intelligent release performance.

Description

technical field [0001] The present invention relates to a dual-targeting and pH-sensitive anti-tumor drug carrier material and its preparation and application, specifically a molecular targeting based on magnetic field targeting and folic acid receptors on the surface of tumor cells based on multifunctional single-layer graphite oxide. A novel drug carrier material with pH-sensitive and controllable release performance, a preparation method and application thereof, belong to the technical field of medicine. Background technique [0002] Since the single-layer graphite (Graphene) was successfully discovered in 2004, because it has an ideal two-dimensional structure, can penetrate the cell membrane and can promote the absorption of small molecules and macromolecules by cells, it is a biomolecule including genes, drugs, etc. Various delivery and intracellular tracking etc. provide many new opportunities. One of the benefits of this nanomaterial is that after oxidation, it has ...

Claims

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Application Information

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IPC IPC(8): A61K47/22A61K47/04A61K47/02A61K49/00A61P35/00
Inventor 杨晓英段宏泉王银松陈永胜马延风黄毅
Owner TIANJIN MEDICAL UNIV
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