Hemostatic bacteriostatic biological dressing and preparation method thereof

A biological dressing and biological material technology, applied in the field of biomedical materials, can solve the problems affecting the antibacterial ability of biological sponges, the influence of nano-silver production, and limited penetration ability, so as to achieve improved hemostatic performance, good hemostatic performance, and antibacterial effect obvious effect

Inactive Publication Date: 2011-01-26
INST OF FIELD OPERATION SURGERY NO 3 MILITARY MEDICL UNIV PLA
View PDF8 Cites 34 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This biological sponge utilizes the antibacterial activity of nano-silver and does not produce drug-resistant bacteria, which improves the antibacterial ability, but this biological sponge can only stop bleeding with the help of the hemostatic property of the biological material itself, so its hemostatic ability is very weak; Moreover

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hemostatic bacteriostatic biological dressing and preparation method thereof
  • Hemostatic bacteriostatic biological dressing and preparation method thereof
  • Hemostatic bacteriostatic biological dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 The biological dressing obtained in this embodiment is spongy, and chitosan is used as the biological dressing base material, the hemostatic drug adopts tranexamic acid, and the cross-linking agent adopts glutaraldehyde. The specific method is:

[0031] (1) Weigh 3 g of chitosan, dissolve it in an acetic acid solution with a concentration of 3% by volume, and make a colloidal liquid with a mass fraction of 3%, and add glutaraldehyde whose weight is 0.01% of the weight of the colloidal liquid, Stir evenly, place at 4°C for 4 hours, then pour into a rectangular container, freeze-dry to form a biological sponge, and finally heat and solidify the biological sponge at 80°C for 5 hours;

[0032] (2) Immerse the biological sponge obtained above in a silver nitrate solution with a concentration of 0.1 mM, place it in a sterilizer at a high temperature of 121°C and a high pressure of 15 psi for 10 minutes, then take it out and rinse it with deionized water to obtain ...

Embodiment 2

[0035] Example 2 The biological dressing obtained in this embodiment is film-like, and is made into the biological dressing matrix with carboxymethyl chitosan, and the hemostatic drug adopts thrombin. The specific method is:

[0036] (1) Weigh 5g of carboxymethyl chitosan, dissolve it in deionized water, and make a colloidal liquid with a mass fraction of 5%, add silver nitrate solution to this colloidal liquid, stir evenly, and then heat the and 15 psi high pressure, place it in a sterilizer for 10 minutes, take it out to get the biological glue containing nano-silver;

[0037](2) Add 5 mg of thrombin to the biological glue containing nano-silver, stir evenly, pour it on a glass or stainless steel plate, cast it into a film, and dry it at room temperature to obtain a film-like hemostatic and antibacterial biological dressing.

[0038] In the film-like hemostatic and antibacterial biological dressing obtained above, the weight of nano-silver is 0.01% of the weight of the bi...

Embodiment 3

[0039] Example 3: The biological dressing obtained in this example is in the shape of a sponge, and chitosan and sodium alginate are used as the biological dressing matrix, the hemostatic drug is tranexamic acid, and the cross-linking agent is genipin. The specific method is:

[0040] (1) Weigh 5g of chitosan and 3g of sodium alginate, dissolve in acetic acid solution with a concentration of 3% by volume, and make a colloidal liquid with a mass fraction of 1%, and add 0.3% of the weight of the colloidal solution Genipin aqueous solution, stirred evenly, placed at 4°C for 4 hours, then poured into a rectangular container, freeze-dried to form a biological sponge, and finally heated and solidified the biological sponge at 100°C for 4 hours;

[0041] (2) Immerse the biological sponge obtained above into a silver nitrate solution with a concentration of 0.25 mM, place it in a sterilizer at a high temperature of 121°C and a high pressure of 15 psi for 15 minutes, then take it out...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides hemostatic bacteriostatic biological dressing and a preparation method thereof. Nano silver and hemostatic medicament are uniformly distributed in a spongy or film-like biological dressing matrix made of a biological material, wherein the weight of the nano silver is 0.01 to 3 percent of the weight of the biological material, and the weight of the hemostatic medicament is 0.1 to 10 percent of the weight of the biological material. The method for preparing the spongy biological dressing comprises the following steps of: soaking the freeze-dried sponge into silver nitrate solution to prepare nano silver-carrying biological sponge at a high temperature under a high pressure, and soaking the nano silver-carrying biological sponge into solution containing the hemostatic medicament to obtain the spongy biological dressing by freeze drying. The method for preparing the film-like biological dressing comprises the following steps of: preparing biological material solution containing silver nitrate into nano silver-carrying solution at a high temperature under a high pressure, adding the hemostatic medicament into the cooled nano silver-carrying solution, casting the mixture to form a film, and drying the film at room temperature to obtain the film-like biological dressing. The hemostatic bacteriostatic biological dressing has the characteristics of safety, no toxicity, good biocompatibility and degradability and obvious bacteriostatic and hemostatic effects; and the preparation method is simple and has strong operability and low cost.

Description

technical field [0001] The invention relates to a biomedical dressing and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] As an important organ of the human body, the skin controls body temperature, prevents infection and loss of body fluids, and maintains a stable internal environment. After skin injury due to wounds, abrasions, burns and ulcers, etc., it is easy to cause bacterial infection, loss of body fluids and various complications. When treating this kind of human skin injury with tissue loss, dressings are usually used to protect the wound to prevent infection and dehydration of the wound, maintain a moist environment conducive to treatment at the wound, improve the therapeutic effect, and promote wound healing. [0003] An ideal dressing should have the following characteristics: (1) safe, non-toxic, and non-irritating; (2) good biocompatibility, preferably degradable; (3) capable of maintaining...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L15/44A61L15/28A61L15/32
Inventor 李东红刁俊林臧家涛刘建仓
Owner INST OF FIELD OPERATION SURGERY NO 3 MILITARY MEDICL UNIV PLA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap