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Salbutamol molecularly imprinted polymer and preparation method thereof

A salbutamol and molecularly imprinted technology, applied in the preparation of albuterol molecularly imprinted polymers, in the field of salbutamol molecularly imprinted polymers, can solve the problems of inability to identify specific molecules, non-specific stationary phases, and no reports on preparation methods, etc. Achieve good recognition ability and selection characteristics, good binding ability and separation ability, and controllable particle size

Inactive Publication Date: 2011-02-02
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the stationary phases currently on the market are not specific and cannot recognize specific molecules.
At present, there is no report about albuterol molecularly imprinted polymer and its preparation method

Method used

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  • Salbutamol molecularly imprinted polymer and preparation method thereof
  • Salbutamol molecularly imprinted polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A salbutamol molecularly imprinted polymer, such as figure 1 As shown, the particle size is about 50nm-100nm, measured by BET nitrogen adsorption method, the pore size is 24.6nm, and the specific surface area is 88.7m 2 / g, the total pore volume is 0.519cm 3 / g.

[0045] Weigh 20 mg of albuterol molecularly imprinted polymer into a polytetrafluoroethylene centrifuge tube, add 5 ml of albuterol in acetonitrile solution, put it in a shaker at room temperature for 12 h, centrifuge at 10000 r / min for 20 min, take the supernatant, and pass through 0.45 Filter with a μm filter membrane, measure the content of salbutamol in the obtained solution by HPLC, and calculate the maximum adsorption capacity Q of the molecularly imprinted polymer according to the change of the solution concentration before and after adsorption max and the equilibrium dissociation constant K d They are 641.33mg / g and 414.94mg / L respectively.

[0046] The molecularly imprinted polymer was placed in a...

Embodiment 2

[0052] A salbutamol molecularly imprinted polymer, the particle size is about 30nm-100nm, measured by BET nitrogen adsorption method, the pore size is 15nm, and the specific surface area is 126m 2 / g.

[0053] The maximum adsorption capacity Q of molecularly imprinted polymers max and the equilibrium dissociation constant K d Be respectively 203mg / g and 71mg / L, measure and calculate method with embodiment 1.

[0054] The static adsorption partition coefficient K of the molecularly imprinted polymer is 0.5, and the recognition factor β is 5.2, and the measurement and calculation methods are the same as in Example 1.

[0055] Its preparation method comprises the following steps:

[0056] (1) Add the template molecule salbutamol and the polymerized monomer acrylamide in a ratio of 1:3 to the porogen methanol solution whose ratio to salbutamol is 300ml / mmol, and stir at 8°C for 0.5h;

[0057] (2) adding in the product of step (1) is that the crosslinking agent trimethoxypropan...

Embodiment 3

[0060] A salbutamol molecularly imprinted polymer, the particle size is about 80nm-150nm, measured by BET nitrogen adsorption method, the pore size is 30nm, and the specific surface area is 30.8m 2 / g.

[0061] The maximum adsorption capacity Q of molecularly imprinted polymers max and the equilibrium dissociation constant K d Be respectively 689mg / g and 507.9mg / L, measure and calculate method with embodiment 1.

[0062] The static adsorption distribution coefficient K of the molecularly imprinted polymer is 1.0, and the recognition factor β is 10, and the measurement and calculation methods are the same as in Example 1.

[0063] Its preparation method comprises the following steps:

[0064] (1) Add the template molecule salbutamol and the polymerized monomer trifluoromethacrylic acid in a ratio of 1:8 to the porogen acetone solution whose ratio to salbutamol is 70ml / mmol, and stir at 5°C for 2.5h;

[0065] (2) Add a cross-linking agent with a ratio of 1:30 to salbutamol a...

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Abstract

The invention discloses a salbutamol molecularly imprinted polymer and a preparation method thereof, in particular relates to a salbutamol molecularly imprinted polymer which has good recognition capability and selectivity characteristics and a preparation method thereof. Each polymer particle has the characteristics that the particle diameter is 30nm-150nm, the aperture is 15-30nm, the specific surface area is 30-120m<2> / g, the maximum binding capacity Qmax is 200-700mg / g, the dissociation constant Kd is 70-500mg / L, the static adsorption distribution coefficient K is 0.5-1.0, and the recognition factor beta is 5-10. The polymer particles have uniform size, good recognition capability and selectivity characteristics for salbutamol, and good combining capacity and separating capacity. The invention has the advantages of simple preparation method, good reproducibility, easy process control and controllable polymer particle size.

Description

technical field [0001] The invention relates to a salbutamol molecularly imprinted polymer, in particular to a molecularly imprinted polymer with good recognition ability and selectivity for albuterol. [0002] The invention also relates to a preparation method of albuterol molecularly imprinted polymer. Background technique [0003] Salbutamol (Salbutamol, SAL) is used in the treatment of bronchial asthma due to its bronchodilator effect. In addition, because the drug can also promote the growth of muscle tissue, it is also used in the beef cattle industry to increase the proportion of lean meat in cattle, to replace the commonly used clenbuterol hydrochloride, and at the same time, it can be used as a stimulant to improve the physical fitness and performance of athletes . However, long-term or excessive use of these drugs is illegal and harmful to physiology, and serious toxic reactions will occur when the drugs are accumulated to a certain amount. Therefore, these drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/56C08F2/44C08F220/04C08F220/28C08F222/14C08F220/06C08J9/26C08K5/17
Inventor 杨敏莉沈蕊莲储晓刚王大宁
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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