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Combined drug of Ginkgolide and Ginkgo flavone as well as preparation and application thereof

A technology of ginkgolides and ginkgo flavonoids, which is applied in the field of ginkgolides and ginkgo flavonoids combined drugs and their preparations, and can solve the problem that the ratio of ginkgolides has not changed for many years

Inactive Publication Date: 2011-03-02
JIANGSU TIANAN BIOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In other words, in the ginkgo biloba medicines currently on the market, the ratio of ginkgo yellow esters to ginkgolides has not changed for many years

Method used

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  • Combined drug of Ginkgolide and Ginkgo flavone as well as preparation and application thereof
  • Combined drug of Ginkgolide and Ginkgo flavone as well as preparation and application thereof
  • Combined drug of Ginkgolide and Ginkgo flavone as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] prescription:

[0018] Ginkgolide Extract 30g

[0019] Ginkgo Flavonoid Extract 23g

[0020] Microcrystalline Cellulose 25g

[0021] Sodium carboxymethyl starch 28g

[0022] Talc powder 2g

[0023] Povidone K30 (PVP K30 ) 6g

[0024] Preparation method: Weigh ginkgolide extract and ginkgo flavone extract according to the prescription, add microcrystalline cellulose and sodium carboxymethyl starch, and mix well. Added 4% PVP K30 The liquid is mixed and kneaded to make a soft material, passed through a 20-mesh sieve, and made into wet granules. After drying at 50-60°C for 2 hours, granulate with 18-mesh sieve, add talcum powder, mix evenly, and fill in capsules to obtain 1000 capsules.

Embodiment 2

[0026] prescription:

[0027] Ginkgolide Extract 40g

[0028] Ginkgo Flavonoid Extract 48g

[0029] salad oil 386g

[0030] Beeswax 16g

[0031] Hydrogenated Palm Oil 28g

[0032] Soy Lecithin 20g

[0033] Methyl silicone oil 0.5g

[0034] Preparation method: take salad oil, add beeswax and hydrogenated palm oil, heat to dissolve, let cool, add soybean lecithin, stir well, add ginkgolide extract, ginkgo flavonoid extract, stir well, colloid mill to grind well, add Methyl silicone oil, degassed under reduced pressure, and made into 1000 soft capsules by hydraulic pressure.

Embodiment 3

[0036] prescription:

[0037] Ginkgolide Extract 12g

[0038] Ginkgo Flavonoid Extract 48g

[0039] Sucrose 500g

[0040] Starch 380g

[0041] Whipped starch 50g

[0042] Fragrance 2ml

[0043] Preparation method: Weigh the prescribed amount of ginkgolide extract, ginkgo flavonoid extract, sucrose and starch, crush through a 100-mesh sieve, and fully mix for half an hour; wash the beaten starch into 10% starch slurry, and let it cool for later use. Add the starch slurry to the mixed material under stirring to make a soft material, pass through a 14-mesh sieve, and make wet granules. Dry the wet granules at 55°C for 3 hours, spray the essence into the whole granules, let them stand for half an hour, and pack them into 1000 packs

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Abstract

The invention discloses a combined drug of Ginkgolide and Ginkgo flavone as well as a preparation and an application thereof, relating to a composition method and a preparation method of a pharmaceutic preparation, particularly relating to a composition method of Ginkgolide and Ginkgo flavone as well as a preparation and an application thereof. The combined drug in the invention has the effective components of Ginkgolide (lactone extracts of Ginkgo leaves) and Ginkgo flavone (flavonoid extracts of Ginkgo leaves) in proportion, wherein the weight ratio of the Ginkgolide to the Ginkgo flavone is 3-1:2.3-10. The preparation is an oral preparation or an injection preparation and comprises medical auxiliary materials of oral preparation or injection preparation. The oral preparation comprises hard capsules, soft capsules, granules, pills, tablets, dispersible tablets and gastric floating tablets. The injection preparation comprises small volume injections, large volume injections and powder-needle injections. The invention also discloses the application of the combined drug of the Ginkgolide and the Ginkgo flavone in preparing drugs for curing blockage of collaterals caused by phlegm and blood stasis in coronary hear disease, angina pectoris and apoplexy.

Description

technical field [0001] The present invention relates to a combination method of ginkgolide and ginkgo flavonoids and its preparation and application, and relates to a combination method and preparation method of a pharmaceutical preparation, more specifically, to a combination method of ginkgolide and ginkgo flavonoids and its application. formulations, applications. Background technique [0002] The active ingredients of Ginkgo biloba are mainly flavonoids and lactones. Ginkgo flavonoids can scavenge oxygen free radicals, protect lipids against peroxidation, reduce microvascular permeability, relax arterioles, and improve microcirculation. Ginkgolides have anti-platelet activating factor effects, and there is a complex cross between the two , Synergy. The current European standard ginkgo extract (EGb-761, such as Tebonin in Germany and Tanakan in France, etc.) contains total flavonoids ≥ 24%, and total lactones ≥ 6%. The domestic Ginkgo biloba drug standards are also form...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/352A61P9/10A61P7/02
Inventor 张国清陶洪尧
Owner JIANGSU TIANAN BIOPHARML