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Pharmaceutical composition for treating skin pruritus

A technology for pruritic skin disease and composition, which is applied in the field of pharmaceutical compositions, can solve the problems of decreased curative effect, high price, and recurrence of drug withdrawal, and achieves the effects of promoting transdermal absorption, stable and reliable quality, and easy to carry and use.

Active Publication Date: 2011-03-30
CHONGQING PHARSCIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to the survey, the traditional Chinese medicine compound external preparations currently used for the treatment of pruritus skin diseases are limited and the curative effect is not good. Because of the anti-inflammatory and anti-proliferative effects of glucocorticoids, the treatment may achieve better results in the near future, but the ensuing complications Glucocorticosteroid dependence and withdrawal relapse, compromising treatment efficacy
Long-term application may also cause side effects such as skin thinning, hair follicle atrophy, acne and even hormone-dependent dermatitis
In addition, in the clinical work of medical workers, it is also found that the initial use of glucocorticosteroid preparations usually shows a good therapeutic effect, and the curative effect decreases significantly after continued use for several days, that is, rapid desensitization and tolerance of externally applied hormones. And then increased the difficulty of treatment, almost helpless to intractable cases
In addition, topical immunosuppressants are gradually being used in clinical practice. Although they have significant curative effects and have no side effects of glucocorticoid hormones, they are expensive, and the economic burden of long-term use is heavy for patients.
At the same time, one of the reasons why it is difficult for many dermatologists to work is that it is difficult to find a drug with high efficiency, low toxicity and reasonable price to meet the needs of patients' conditions and economic capabilities

Method used

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  • Pharmaceutical composition for treating skin pruritus
  • Pharmaceutical composition for treating skin pruritus
  • Pharmaceutical composition for treating skin pruritus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Embodiment 1: the preparation of cream

[0106] Ingredients: Weigh 110g of Sophora flavescens, 55g of Phellodendron cortex, 110g of Cnidium chinensis, 27.5g of red stone fat, 5.5g of borneol for later use;

[0107] Ethanol extraction: put the weighed Sophora flavescens, Cortex Phellodendri, and Fructus Cnidii into an extraction tank, heat and reflux for 2 hours with 8 times by weight of 70% ethanol, collect the extract, add 7 times by weight of 70% ethanol and heat it back for 2 hours , collect the extracts, combine the secondary extracts, filter, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.15-1.20 (60°C), and set aside;

[0108] Superfine pulverization: take red stone fat, grind it into superfine powder with a particle size of less than 10um with a superfine pulverizer, and set aside;

[0109] Preparation of the oil phase: Take 100g of cetyl alcohol, 140g of white petrolatum, and 60g of liquid paraffin, heat to ...

Embodiment 2

[0112] Embodiment 2: the preparation of Babu ointment

[0113] Ingredients: Weigh 130g of Sophora flavescens, 40g of Phellodendron cortex, 90g of Cnidium chinensis, 30g of red stone fat, 7g of borneol for later use;

[0114] Ethanol extraction: put the weighed Sophora flavescens, Cortex Phellodendri, and Fructus Cnidii in an extraction tank, heat and reflux for 3 hours with 6 times by weight of 75% ethanol, collect the extract, add 6 times by weight of 75% ethanol and heat it back for 2 hours , collect the extracts, combine the secondary extracts, filter, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.15-1.20 (60°C), and set aside;

[0115] Superfine pulverization: take red stone fat, grind it into superfine powder with a particle size of less than 10um with a superfine pulverizer, and set aside;

[0116] The thick paste, superfine powder, and borneol are added to glycerin, gelatin and other bases to make a thick paste, co...

Embodiment 3

[0117] Embodiment 3: the preparation of spray

[0118] Ingredients: Take 90g of Sophora flavescens, 70g of Cortex Phellodendri, 130g of Cnidium chinensis, 20g of red stone fat, and 3g of borneol for later use;

[0119] Ethanol extraction: put the weighed Sophora flavescens, Cortex Phellodendri, and Fructus Cnidii in an extraction tank, soak for 12 hours with 10 times by weight of 60% ethanol, heat and reflux for 2 hours, collect the extract, and add 8 times by weight of 60% ethanol to heat and reflux After 1 hour, collect the extracts, combine the secondary extracts, filter, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.15-1.20 (60°C), and set aside;

[0120] Superfine pulverization: take red stone fat, grind it into superfine powder with a particle size of less than 5um with a superfine pulverizer, and set aside;

[0121] The above-mentioned thick ointment, superfine powder and borneol are added into the mixed solution o...

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Abstract

The invention discloses a pharmaceutical composition for treating skin pruritus and a preparation method thereof. The pharmaceutical composition is prepared from the raw medical materials, such as radix sophorae flavescentis, golden cypress, fructus cnidii, halloysitum rubrum, borneol, and the like. The preparation method comprises the following steps of: extracting the raw medical materials with ethanol or water, carrying out ultrafinely crushing and other processes to prepare thick paste or thin paste and superfine powder; and adding conventional auxiliary materials according to a conventional process to prepare various external preparations. Accordingly, the pharmaceutical composition of the invention has the functions of reducing fever, removing dampness, killing insects and relieving itching, has accurate curative effect, stable and reliable quality, long service life, portability and convenient use and is particularly suitable for various kinds of skin pruritus.

Description

field of invention [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating pruritus skin diseases. Background technique [0002] Pruritic skin diseases refer to a group of skin diseases characterized by skin itching, including pruritus skin diseases that coexist with primary skin rashes such as eczema, psoriasis, neurodermatitis, papular urticaria , insect bite dermatitis, pityriasis erythra, etc., also includes pruritus with only pruritus and lack of primary skin rash. The drug in this study is for pruritic skin disease with primary rash. [0003] In recent years, the incidence of pruritic skin diseases has been on the rise, which may be related to changes in climate and environment, the application of a large number of chemicals in daily life, mental stress, accelerated pace of life, and changes in dietary structure. And a lot of pruritus skin causes its recurrence, intractability, pruritus and lingering co...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61P17/04A61K31/045A61K33/26
Inventor 艾儒棣杨凡谭正怀王显凤万慧
Owner CHONGQING PHARSCIN PHARM CO LTD
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