Method for synthesizing luteolin

A technology of luteolin and ethanol, which is applied in the synthesis field of preparing luteolin, can solve the problems of low extraction rate, and achieve the effects of high synthesis efficiency, high yield, and easy industrial production
CN102002028BActive Publication Date: 2012-08-22西安炎黄经方医药研发有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
西安炎黄经方医药研发有限公司
Publication Date
2012-08-22

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Abstract

The invention discloses a method for synthesizing luteolin, comprising the following steps of: adding rutin at the room temperature of 20-30DEG C in alkali water and stirring for dissolving; adding a reducing agent of sodium hydrosulfite with equivalent weight of 6.3 once, continuously heating up to 100DEG C and stirring for 12 hours; after the HPLC (High Performance Liquid Chromatography) monitoring reaction is finished, cooling, adding dilute hydrochloric acid or dilute sulfuric acid, adjusting the pH to be 3-4, standing for 24 hours for separating out a solid and filtering; washing a filtering cake with water twice to remove salts contained in the product; and drying to obtain a crude product, continuously crystalizing with ethanol to obtain a pure product with the purity being more than 95 percent. Compared with the prior art, the invention has the advantages of high synthetic efficiency, high yield, low energy consumption, low pollution, greenness, environmental protection and the like and is easy for industrialized production.
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Description

technical field

[0001] The invention relates to the field of substance synthesis, in particular to a synthesis method for preparing luteolin from natural extracts. Background technique

[0002] Luteolin is the same active ingredient isolated from whole-leaf Qinglan and Anhui Prunella vulgaris, the extraction rate in the prior art is very low, 2 / 10,000, and its structure is 3', 4', 5, 7-4 Hydroxyisoflavones. According to reports, this product has a good curative effect on inflammation, tumor, allergy and inflammatory demyelinating diseases. It can also inhibit a variety of viruses. It has been used clinically and made into medicine. Therefore, luteolin has a broad market prospect. Contents of the invention

[0003] The object of the present invention is to provide a new method for synthesizing luteolin with rutin as raw material through one-step chemical reaction.

[0004] The specific process of this method is to add rutin into alkaline water at a temperature of 20-30...

Claims

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