Bone repair stent material and preparation method thereof

A scaffold material and bone repair technology, applied in medical science, prosthesis, etc., can solve the problem of difficulty in obtaining raw materials, and achieve the effects of simple preparation and processing methods, strong controllability, and promotion of adhesion

Active Publication Date: 2013-08-21
邓旭亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is that the raw material existing in calf bone as bone repair scaffold material is difficult to obtain and has ethical problems, thereby providing a bone repair scaffold material and its preparation method

Method used

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  • Bone repair stent material and preparation method thereof
  • Bone repair stent material and preparation method thereof
  • Bone repair stent material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Fresh sika deer antler bones were taken, and the cortical bone around the core cancellous bone structure of the antler trunk was excised with a mechanical cutter to obtain a 10×10×10 mm antler cancellous bone block.

[0023] (2) The antler cancellous bone obtained in step (1) was soaked in 0.6mol / L NaOH for 2 hours, chloroform for 2 hours, 30% hydrogen peroxide for 12 hours, 2mol / L calcium chloride for 3 hours, and 10mol / L calcium chloride for 2 hours. Soak in L lithium chloride for 6 hours, wash with deionized water 5 times between each step, and dry at a constant temperature of 80° C. for 1 day.

[0024] (3) Put the dried product obtained in step (2) into a high-temperature sintering furnace for calcination under air atmosphere, the sintering temperature is 1000°C, the heating rate is 5°C / min, the sintering time is 6h, and the cooling rate is 5°C / min .

[0025] The bone repair scaffold material obtained through the above steps contains hydroxyapatite, which is a ...

Embodiment 2

[0027] (1) Fresh red deer antler bones were taken, and the cortical bone around the core cancellous bone structure of the antler trunk was excised with a wire cutting machine to obtain an antler cancellous slider body of 10×20×10 mm.

[0028] (2) The antler cancellous bone obtained in step (1) was soaked in 0.1mol / L NaOH for 20 hours, chloroform for 5 hours, 30% hydrogen peroxide for 48 hours, 1mol / L calcium chloride for 8 hours, and 3mol / L calcium chloride for 8 hours. Soak in L lithium chloride for 8 hours, wash 3 times with deionized water between each step, and dry at a constant temperature of 50° C. for 3 days.

[0029] (3) Put the dried product obtained in step (2) into a high-temperature sintering furnace for calcination under air atmosphere, the sintering temperature is 600°C, the heating rate is 1°C / min, the sintering time is 48h, and the cooling rate is 10°C / min .

[0030] The natural bone repair scaffold material obtained through the above steps has a porous interp...

Embodiment 3

[0032] (1) Fresh sambar antler bones were taken, and the cortical bone around the core cancellous bone structure of the antler trunk was excised with a wire cutting machine to obtain a 10×15×10 mm antler cancellous bone block.

[0033] (2) The antler cancellous bone obtained in step (1) was soaked in 0.5mol / L NaOH for 12 hours, chloroform for 1 hour, 30% hydrogen peroxide for 24 hours, 2mol / L calcium chloride for 2 hours, and 10mol / L calcium chloride for 2 hours. Soak in L lithium chloride for 24 hours, wash with deionized water 4 times between each step, and dry at a constant temperature of 55° C. for 2 days.

[0034] (3) Place the dried product obtained in step (2) into a high-temperature sintering furnace for calcination under air atmosphere, the sintering temperature is 800°C, the heating rate is 2°C / min, the sintering time is 24h, and the cooling rate is 1°C / min .

[0035] The natural bone repair scaffold material obtained through the above steps has a porous interpenetr...

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Abstract

The invention relates to a bone repair stent material and a preparation method thereof, and the bone repair stent material can be used to overcome the defects of difficult obtainment of raw materials and ethical problems in the existing practice of taking a small bovine bone as the bone repair stent material. The bone repair stent material contains hydroxyapatite, the material is in a porous interpenetrating network structure, the porosity is 30%-85%, the macropore diameter is 100-800 microns, and the micropore diameter is 10-60 microns. The stent material can be widely used in repair treatment of bone defects and bone loss caused by diseases, traffic accidents, sports injuries and the like.

Description

technical field [0001] The invention relates to a surgical repair material and a preparation method thereof, in particular to a bone repair scaffold material and a preparation method thereof. Background technique [0002] At present, there are many patients with bone defects and loss caused by diseases, traffic accidents and sports trauma every year in the world, so the demand for bone repair materials for treatment is very large. Although the current research hotspots in the field of bone repair are focused on artificial synthetic materials to avoid the pain caused by autologous bone grafts, which are known as the "gold standard" of bone repair, including donor site surgery and dysfunction, and the sources are limited, but The scope of clinical application of artificial bone repair materials is still very narrow. Xenogeneic bone derived from calf bone is still used clinically, and its repairing effect has been widely accepted at present, but its raw material is from slaugh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/56A61L27/36
Inventor 邓旭亮张学慧杨小平
Owner 邓旭亮
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