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Method for preparing single polyelectrolyte microcapsule based on ferrocene hydrophobic interaction

A hydrophobic interaction, polyelectrolyte technology, applied in the field of preparing hollow microcapsules, can solve the problems of limited promotion and application, waste of raw materials, and many steps, and achieve the effects of wide material sources, enhanced permeability, and simple process.

Inactive Publication Date: 2012-11-28
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this preparation method has the disadvantages of many steps, long time-consuming, and waste of raw materials, which limit its promotion and application, especially it is difficult to adapt to the requirements of large-scale rapid preparation
At the same time, the size and permeability of microcapsules are regulated by redox reactions, which have not been reported

Method used

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  • Method for preparing single polyelectrolyte microcapsule based on ferrocene hydrophobic interaction
  • Method for preparing single polyelectrolyte microcapsule based on ferrocene hydrophobic interaction
  • Method for preparing single polyelectrolyte microcapsule based on ferrocene hydrophobic interaction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1) Ca(NO 3 ) 2 and Na 2 CO 3 To make 0.33M aqueous solution respectively, take 100mL Ca(NO 3 ) 2 Add PAH to the solution, PAH is in Ca(NO 3 ) 2 The concentration in the solution is 2mg / mL, stir to make it evenly mixed; quickly add 100mL Na 2 CO 3 Aqueous solution, keep stirring for 40 seconds, and then let it stand to react until all the generated particles are completely precipitated; the obtained particles are collected by centrifugation, washed 3 times with water, and CaCO with a diameter of about 5.5 microns is obtained. 3 Particles, whose scanning electron microscope pictures are shown in figure 1 ; this CaCO 3 The microparticles are templates for colloidal particles doped with PAH.

[0024] 2) The CaCO doped with PAH obtained in step 1) 3 Put the microparticles into 20 mL of ferrocene formaldehyde methanol solution with a concentration of 20 mg / mL, shake to form a suspension, and keep shaking for 3 hours to react the amino group of PAH with the Schiff b...

Embodiment 2

[0027] 1) Ca(NO 3 ) 2 and Na 2 CO 3 To make 0.33M aqueous solution respectively, take 70mL Ca(NO 3 ) 2 Add PAH to the solution, PAH is in Ca(NO 3 ) 2 The concentration in the solution is 5mg / mL, stir to make it evenly mixed; quickly add 70mL Na 2 CO 3 Aqueous solution, keep stirring for 50 seconds, and then let it stand to react until all the generated particles are completely precipitated; the obtained particles are collected by centrifugation, washed 3 times with water, and colloidal CaCO doped with PAH is obtained 3 particle.

[0028] 2) The CaCO doped with PAH obtained in step 1) 3 Put the microparticles into 30 mL of ferrocene formaldehyde methanol solution with a concentration of 10 mg / mL, shake to form a suspension, and keep shaking for 4 hours to react the amino group of PAH with the Schiff base of ferrocene formaldehyde. Then centrifuge, wash and disperse the colloidal particles with ethanol; add excess NaBH to the ethanol suspension of the colloidal particl...

Embodiment 3

[0031] 1) Ca(NO 3 ) 2 and Na 2 CO 3 To make 0.33M aqueous solution respectively, take 50mL Ca(NO 3 ) 2 Add PAH to the solution, PAH is in Ca(NO 3 ) 2 The concentration in the solution is 10mg / mL, stir to make it evenly mixed; quickly add 50mL Na 2 CO 3 Aqueous solution, keep stirring for 60 seconds, and then let it stand for reaction until all the generated particles are completely precipitated; the obtained particles are collected by centrifugation and washed 3 times with water to obtain colloidal CaCO doped with PAH 3 particle.

[0032] 2) The CaCO doped with PAH obtained in step 1) 3 Put the microparticles into 20 mL of ferrocene formaldehyde methanol solution with a concentration of 30 mg / mL, shake to form a suspension, and keep shaking for 4 hours to react the amino group of PAH with the Schiff base of ferrocene formaldehyde. Then centrifuge, wash and disperse the colloidal particles with ethanol; add excess NaBH to the ethanol suspension of the colloidal partic...

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Abstract

The invention discloses a method for preparing a single polyelectrolyte microcapsule based on ferrocene hydrophobic interaction. The method is characterized by taking a polyelectrolyte doped colloid particle as a template, utilizing amido in polyelectrolyte to react with ferrocene carboxaldehyde, deacidizing a formed shiff's base chemical bond to an iumine bond by utilizing sodium borohydride to obtain the polyelectrolyte modified by ferrocene, and removing the colloid particle to obtain the single polyelectrolyte microcapsule with the microcapsule wall modified by the ferrocene. A large number of the polyelectrolyte doped in the colloid particle can be remained in the microcapsule so that the microcapsule has a thick microcapsule wall and a stable structure. Meanwhile, because the ferrocene has good redox properties, the microcapsule has sensitive redox responsiveness. By utilizing the characteristic, the microcapsule can realize molecular encapsulation and release controlled by redox. The microcapsule prepared by adopting the method of the invention has broad potential application value on aspects of nanometer materials, medicament release, biosensors, and the like.

Description

technical field [0001] The invention relates to a method for preparing hollow microcapsules. In particular, a method for the preparation of single polyelectrolyte microcapsules utilizing ferrocene-hydrophobic interactions. Background technique [0002] Microcapsules are substances that separate the space inside the capsule from the space outside the capsule to form a specific geometric structure by a film-forming substance. The shape of the microcapsules is mainly spherical, and can also be oval, square or rectangular, polygonal and various irregular shapes. The size of traditional microcapsules is usually on the order of microns to millimeters, and the wall thickness is from submicron to hundreds of microns. Microcapsules have very important applications in food, medicine, cosmetics, bioengineering and tissue engineering. There are many methods for the preparation of microcapsules. According to the principle of capsule wall formation, the traditional preparation techniq...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02
Inventor 高长有王志鹏
Owner ZHEJIANG UNIV
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